6YG9
CRYSTAL STRUCTURE OF HUMAN SERUM ALBUMIN (HSA) IN COMPLEX WITH GN-07.
Summary for 6YG9
| Entry DOI | 10.2210/pdb6yg9/pdb |
| Related | 6yau |
| Descriptor | Serum albumin, MYRISTIC ACID, 20-[[(2~{S})-5-[2-[2-[2-[2-[2-[2-(diethylamino)-2-oxidanylidene-ethoxy]ethoxy]ethylamino]-2-oxidanylidene-ethoxy]ethoxy]ethylamino]-1-oxidanyl-1,5-bis(oxidanylidene)pentan-2-yl]amino]-20-oxidanylidene-icosanoic acid, ... (4 entities in total) |
| Functional Keywords | drug transport, fatty acid binding, liver imaging, nash, human serum albumin, transport protein |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 68758.51 |
| Authors | Schreuder, H.A.,Liesum, A. (deposition date: 2020-03-27, release date: 2021-01-13, Last modification date: 2024-10-09) |
| Primary citation | Mishra, A.,Castaneda, T.R.,Bader, E.,Elshorst, B.,Cummings, S.,Scherer, P.,Bangari, D.S.,Loewe, C.,Schreuder, H.,Poverlein, C.,Helms, M.,Jones, S.,Zech, G.,Licher, T.,Wagner, M.,Schudok, M.,de Hoop, M.,Plowright, A.T.,Atzrodt, J.,Kannt, A.,Laitinen, I.,Derdau, V. Triantennary GalNAc Molecular Imaging Probes for Monitoring Hepatocyte Function in a Rat Model of Nonalcoholic Steatohepatitis. Adv Sci, 7:2002997-2002997, 2020 Cited by PubMed Abstract: Nonalcoholic steatohepatitis (NASH) is a progressive form of nonalcoholic fatty liver disease that can lead to irreversible liver cirrhosis and cancer. Early diagnosis of NASH is vital to detect disease before it becomes life-threatening, yet noninvasively differentiating NASH from simple steatosis is challenging. Herein, bifunctional probes have been developed that target the hepatocyte-specific asialoglycoprotein receptor (ASGPR), the expression of which decreases during NASH progression. The results show that the probes allow longitudinal, noninvasive monitoring of ASGPR levels by positron emission tomography in the newly developed rat model of NASH. The probes open new possibilities for research into early diagnosis of NASH and development of drugs to slow or reverse its progression. PubMed: 33344141DOI: 10.1002/advs.202002997 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.89 Å) |
Structure validation
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