5ACW
 
 | | VIM-2-1, Discovery of novel inhibitor scaffolds against the metallo- beta-lactamase VIM-2 by SPR based fragment screening | | 分子名称: | 4-methyl-5-(trifluoromethyl)-1,2,4-triazole-3-thiol, BETA-LACTAMASE, CHLORIDE ION, ... | | 著者 | Christopeit, T, Carlsen, T.J.O, Helland, R, Leiros, H.K.S. | | 登録日 | 2015-08-18 | | 公開日 | 2015-11-04 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Discovery of Novel Inhibitor Scaffolds Against the Metallo-Beta-Lactamase Vim-2 by Spr Based Fragment Screening
J.Med.Chem., 58, 2015
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4BZ4
 | | CorA is a surface-associated copper-binding protein important in Methylomicrobium album BG8 copper acquisition | | 分子名称: | CALCIUM ION, COPPER (I) ION, COPPER-REPRESSIBLE POLYPEPTIDE, ... | | 著者 | Johnson, K.A, Ve, T, Pedersen, R.B, Lillehaug, J.R, Jensen, H.B, Helland, R, Karlsen, O.A. | | 登録日 | 2013-07-24 | | 公開日 | 2014-02-19 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Cora is a Copper Repressible Surface-Associated Copper(I)-Binding Protein Produced in Methylomicrobium Album Bg8.
Plos One, 9, 2014
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4C4Q
 | | Cryo-EM map of the CSFV IRES in complex with the small ribosomal 40S subunit and DHX29 | | 分子名称: | INTERNAL RIBOSOMAL ENTRY SITE | | 著者 | Hashem, Y, desGeorges, A, Dhote, V, Langlois, R, Liao, H.Y, Grassucci, R.A, Pestova, T.V, Hellen, C.U.T, Frank, J. | | 登録日 | 2013-09-07 | | 公開日 | 2013-10-30 | | 最終更新日 | 2024-05-08 | | 実験手法 | ELECTRON MICROSCOPY (8.5 Å) | | 主引用文献 | Hepatitis-C-Virus-Like Internal Ribosome Entry Sites Displace Eif3 to Gain Access to the 40S Subunit
Nature, 503, 2013
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4BUR
 | | Crystal structure of the reduced human Apoptosis inducing factor complexed with NAD | | 分子名称: | APOPTOSIS INDUCING FACTOR 1, MITOCHONDRIAL, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Martinez-Julvez, M, Herguedas, B, Hermoso, J.A, Ferreira, P, Villanueva, R, Medina, M. | | 登録日 | 2013-06-23 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.88 Å) | | 主引用文献 | Structural Insights Into the Coenzyme Mediated Monomer-Dimer Transition of the Pro-Apoptotic Apoptosis Inducing Factor.
Biochemistry, 53, 2014
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4ROT
 | | Crystal structure of esterase A from Streptococcus pyogenes | | 分子名称: | Esterase A, OXALATE ION, ZINC ION | | 著者 | Bennett, M.D, Holland, R, Coulibaly, F, Loo, T.S, Norris, G.E, Anderson, B.F. | | 登録日 | 2014-10-28 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structure of esterase A from Streptococcus pyogenes
To be Published
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4ER8
 | | Structure of the REP associates tyrosine transposase bound to a REP hairpin | | 分子名称: | DNA (32-MER), NICKEL (II) ION, TnpArep for protein | | 著者 | Messing, S.A.J, Ton-Hoang, B, Hickman, A.B, Ghirlando, R, Chandler, M, Dyda, F. | | 登録日 | 2012-04-19 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The processing of repetitive extragenic palindromes: the structure of a repetitive extragenic palindrome bound to its associated nuclease.
Nucleic Acids Res., 40, 2012
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6G3R
 | | Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Structure one of two TEW-HSP70 structures deposited. | | 分子名称: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | | 著者 | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | | 登録日 | 2018-03-26 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.
PLoS ONE, 13, 2018
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6G3S
 | | Structure of tellurium-centred Anderson-Evans polyoxotungstate (TEW) bound to the nucleotide binding domain of HSP70. Second structure of two TEW-HSP70 structures deposited. | | 分子名称: | 6-tungstotellurate(VI), ADENOSINE-5'-DIPHOSPHATE, Heat shock 70 kDa protein 1A, ... | | 著者 | Mac Sweeney, A, Chambovey, A, Wicki, M, Mueller, M, Artico, N, Lange, R, Bijelic, A, Breibeck, J, Rompel, A. | | 登録日 | 2018-03-26 | | 公開日 | 2018-10-17 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | The crystallization additive hexatungstotellurate promotes the crystallization of the HSP70 nucleotide binding domain into two different crystal forms.
PLoS ONE, 13, 2018
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1O7D
 | | The structure of the bovine lysosomal a-mannosidase suggests a novel mechanism for low pH activation | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Heikinheimo, P, Helland, R, Leiros, H.S, Leiros, I, Karlsen, S, Evjen, G, Ravelli, R, Schoehn, G, Ruigrok, R, Tollersrud, O.-K, Mcsweeney, S, Hough, E. | | 登録日 | 2002-10-30 | | 公開日 | 2003-03-20 | | 最終更新日 | 2024-10-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The Structure of Bovine Lysosomal Alpha-Mannosidase Suggests a Novel Mechanism for Low-Ph Activation
J.Mol.Biol., 327, 2003
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5UZU
 | | Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | de Jong, N, Geisbrecht, B.V, van Strijp, J, Haas, P, Nijland, R, Ramyar, K, Fevre, C, Guerra, F, Voyich-Kane, J, van Kessel, C, Garcia, B. | | 登録日 | 2017-02-27 | | 公開日 | 2017-07-26 | | 最終更新日 | 2024-11-06 | | 実験手法 | X-RAY DIFFRACTION (2.403 Å) | | 主引用文献 | Immune evasion by a staphylococcal inhibitor of myeloperoxidase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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1EJM
 | | CRYSTAL STRUCTURE OF THE BPTI ALA16LEU MUTANT IN COMPLEX WITH BOVINE TRYPSIN | | 分子名称: | BETA-TRYPSIN, PANCREATIC TRYPSIN INHIBITOR, SULFATE ION | | 著者 | Otlewski, J, Smalas, A, Helland, R, Grzesiak, A, Krowarsch, D. | | 登録日 | 2000-03-03 | | 公開日 | 2001-03-03 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Substitutions at the P(1) position in BPTI strongly affect the association energy with serine proteinases.
J.Mol.Biol., 301, 2000
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4GLX
 | | DNA ligase A in complex with inhibitor | | 分子名称: | 2-amino-6-bromo-7-(trifluoromethyl)-1,8-naphthyridine-3-carboxamide, DNA (26-MER), DNA (5'-D(*AP*CP*AP*AP*TP*TP*GP*CP*GP*AP*CP*CP*C)-3'), ... | | 著者 | Prade, L, Lange, R, Tidten-Luksch, N, Chambovey, A. | | 登録日 | 2012-08-15 | | 公開日 | 2012-10-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Bioorg.Med.Chem.Lett., 22, 2012
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4GLW
 | | DNA ligase A in complex with inhibitor | | 分子名称: | 7-methoxy-6-methylpteridine-2,4-diamine, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ... | | 著者 | Prade, L, Lange, R, Tidten-Luksch, N, Chambovey, A. | | 登録日 | 2012-08-15 | | 公開日 | 2012-10-10 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure-guided design, synthesis and biological evaluation of novel DNA ligase inhibitors with in vitro and in vivo anti-staphylococcal activity.
Bioorg.Med.Chem.Lett., 22, 2012
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4GZY
 | | Crystal structures of bacterial RNA Polymerase paused elongation complexes | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Weixlbaumer, A, Leon, K, Landick, R, Darst, S.A. | | 登録日 | 2012-09-06 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3.5054 Å) | | 主引用文献 | Structural basis of transcriptional pausing in bacteria.
Cell(Cambridge,Mass.), 152, 2013
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3RPU
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4GZZ
 | | Crystal structures of bacterial RNA Polymerase paused elongation complexes | | 分子名称: | DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ... | | 著者 | Weixlbaumer, A, Leon, K, Landick, R, Darst, S.A. | | 登録日 | 2012-09-06 | | 公開日 | 2013-02-13 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (4.2927 Å) | | 主引用文献 | Structural basis of transcriptional pausing in bacteria.
Cell(Cambridge,Mass.), 152, 2013
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4IAO
 | | Crystal structure of Sir2 C543S mutant in complex with SID domain of Sir4 | | 分子名称: | ADENOSINE-5-DIPHOSPHORIBOSE, NAD-dependent histone deacetylase SIR2, Regulatory protein SIR4, ... | | 著者 | Hsu, H.C, Wang, C.L, Wang, M, Yang, N, Chen, Z, Sternglanz, R, Xu, R.M. | | 登録日 | 2012-12-07 | | 公開日 | 2012-12-26 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.901 Å) | | 主引用文献 | Structural basis for allosteric stimulation of Sir2 activity by Sir4 binding
Genes Dev., 27, 2013
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3QWL
 | | Crystal structure of human TBC1 domain family member 7 | | 分子名称: | TBC1 domain family member 7, UNKNOWN ATOM OR ION | | 著者 | Guan, X, Tempel, W, Tong, Y, Wernimont, A.K, Landry, R, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | | 登録日 | 2011-02-28 | | 公開日 | 2011-06-01 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human TBC1 domain family member 7
to be published
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4IUW
 | | Crystal structure of PEPO from Lactobacillus rhamnosis HN001 (DR20) | | 分子名称: | CARBONATE ION, CITRIC ACID, Neutral endopeptidase, ... | | 著者 | Anderson, B.F, Knapp, K.M, Holland, R, Norris, G.E, Christensson, C, Bratt, H, Collins, L.J, Coolbear, T, Lubbers, M.W, Toole, P.W.O, Reid, J.R, Jameson, G.B. | | 登録日 | 2013-01-21 | | 公開日 | 2013-03-20 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of PEPO from Lactobacillus rhamnosis HN001 (DR20)
TO BE PUBLISHED
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1IB1
 | | CRYSTAL STRUCTURE OF THE 14-3-3 ZETA:SEROTONIN N-ACETYLTRANSFERASE COMPLEX | | 分子名称: | 14-3-3 ZETA ISOFORM, COA-S-ACETYL TRYPTAMINE, SEROTONIN N-ACETYLTRANSFERASE | | 著者 | Obsil, T, Ghirlando, R, Klein, D.C, Ganguly, S, Dyda, F. | | 登録日 | 2001-03-26 | | 公開日 | 2001-05-02 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structure of the 14-3-3zeta:serotonin N-acetyltransferase complex. a role for scaffolding in enzyme regulation.
Cell(Cambridge,Mass.), 105, 2001
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1P3Q
 | | Mechanism of Ubiquitin Recognition by the CUE Domain of VPS9 | | 分子名称: | Ubiquitin, Vacuolar protein sorting-associated protein VPS9 | | 著者 | Prag, G, Misra, S, Jones, E.A, Ghirlando, R, Davies, B.A, Horazdovsky, B.F, Hurley, J.H. | | 登録日 | 2003-04-18 | | 公開日 | 2003-06-24 | | 最終更新日 | 2024-10-30 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mechanism of Ubiquitin Recognition by the CUE Domain of Vps9p.
Cell(Cambridge,Mass.), 113, 2003
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1PZ9
 | | Modulation of agrin function by alternative splicing and Ca2+ binding | | 分子名称: | Agrin | | 著者 | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | | 登録日 | 2003-07-10 | | 公開日 | 2004-04-13 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
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1Q0Q
 | | Crystal structure of DXR in complex with the substrate 1-deoxy-D-xylulose-5-phosphate | | 分子名称: | 1-DEOXY-D-XYLULOSE-5-PHOSPHATE, 1-deoxy-D-xylulose 5-phosphate reductoisomerase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Mac Sweeney, A, Lange, R, D'Arcy, A, Douangamath, A, Surivet, J.-P, Oefner, C. | | 登録日 | 2003-07-17 | | 公開日 | 2004-07-20 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The crystal structure of E.coli 1-deoxy-D-xylulose-5-phosphate reductoisomerase in a ternary complex with the antimalarial compound fosmidomycin and NADPH reveals a tight-binding closed enzyme conformation.
J.Mol.Biol., 345, 2005
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1PZ7
 | | Modulation of agrin function by alternative splicing and Ca2+ binding | | 分子名称: | Agrin, CALCIUM ION | | 著者 | Stetefeld, J, Alexandrescu, A.T, Maciejewski, M.W, Jenny, M, Rathgeb-Szabo, K, Schulthess, T, Landwehr, R, Frank, S, Ruegg, M.A, Kammerer, R.A. | | 登録日 | 2003-07-10 | | 公開日 | 2004-04-13 | | 最終更新日 | 2024-11-13 | | 実験手法 | X-RAY DIFFRACTION (1.421 Å) | | 主引用文献 | Modulation of agrin function by alternative splicing and Ca2+ binding.
STRUCTURE, 12, 2004
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1QSM
 | | Histone Acetyltransferase HPA2 from Saccharomyces Cerevisiae in Complex with Acetyl Coenzyme A | | 分子名称: | ACETYL COENZYME *A, HPA2 HISTONE ACETYLTRANSFERASE | | 著者 | Angus-Hill, M.L, Dutnall, R.N, Tafrov, S.T, Sternglanz, R, Ramakrishnan, V. | | 登録日 | 1999-06-22 | | 公開日 | 1999-12-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the histone acetyltransferase Hpa2: A tetrameric member of the Gcn5-related N-acetyltransferase superfamily.
J.Mol.Biol., 294, 1999
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