5WLL
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5W8K
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 29 and NADH | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-(3,4-difluorophenyl)-5-hydroxy-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, GLYCEROL, ... | 著者 | Lukacs, C.M, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5WLJ
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5WLM
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5TON
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5W8I
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 23 and Zinc | 分子名称: | 2-[3-(3,4-difluorophenyl)-5-hydroxy-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | Lukacs, C.M, Abendroth, J. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5WLK
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5W8L
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 59 and NADH | 分子名称: | 1,2-ETHANEDIOL, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-{3-([1,1'-biphenyl]-3-yl)-5-(cyclopropylmethyl)-4-[(4-sulfamoylphenyl)methyl]-1H-pyrazol-1-yl}-1,3-thiazole-4-carboxylic acid, ... | 著者 | Davies, D.R, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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5W8H
| Crystal Structure of Lactate Dehydrogenase A in complex with inhibitor compound 11 | 分子名称: | 2-[3-(4-fluorophenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]-1,3-thiazole-4-carboxylic acid, ACETATE ION, DIMETHYL SULFOXIDE, ... | 著者 | Lukacs, C.M, Dranow, D.M. | 登録日 | 2017-06-21 | 公開日 | 2018-01-17 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Discovery and Optimization of Potent, Cell-Active Pyrazole-Based Inhibitors of Lactate Dehydrogenase (LDH). J. Med. Chem., 60, 2017
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7CKM
| Structure of Machupo virus polymerase bound to Z matrix protein (monomeric complex) | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2020-07-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.37 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7CKL
| Structure of Lassa virus polymerase bound to Z matrix protein | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2020-07-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7ELC
| Structure of monomeric complex of MACV L bound to Z and 3'-vRNA | 分子名称: | 3'-vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELA
| Structure of Lassa virus polymerase in complex with 3'-vRNA and Z mutant (F36A) | 分子名称: | 3-'vRNA promoter, MANGANESE (II) ION, RING finger protein Z, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7EL9
| Structure of Machupo virus L polymerase in complex with Z protein and 3'-vRNA (dimeric complex) | 分子名称: | MANGANESE (II) ION, Machupo virus 3'-vRNA promoter, RING finger protein Z, ... | 著者 | Peng, R, Xu, X, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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7ELB
| Structure of Machupo virus L polymerase in complex with Z protein (dimeric form) | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Peng, R, Xu, X, Peng, Q, Shi, Y. | 登録日 | 2021-04-09 | 公開日 | 2021-05-05 | 最終更新日 | 2021-07-14 | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals. Nat Microbiol, 6, 2021
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5XK8
| Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with GPP | 分子名称: | GERANYL DIPHOSPHATE, MAGNESIUM ION, Undecaprenyl diphosphate synthase | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.304 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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5XWZ
| Crystal structure of a lactonase from Cladophialophora bantiana | 分子名称: | GLYCEROL, MALONATE ION, SODIUM ION, ... | 著者 | Zheng, Y.Y, Liu, W.T, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-06-30 | 公開日 | 2018-05-02 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Characterization and crystal structure of a novel zearalenone hydrolase from Cladophialophora bantiana Acta Crystallogr F Struct Biol Commun, 73, 2017
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5XK9
| Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with GSPP and DMAPP | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, GERANYL S-THIOLODIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.137 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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5XK7
| Crystal structure of Isosesquilavandulyl Diphosphate Synthase from Streptomyces sp. strain CNH-189 in complex with DMAPP | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DIMETHYLALLYL DIPHOSPHATE, MAGNESIUM ION, ... | 著者 | Ko, T.P, Guo, R.T, Liu, W, Chen, C.C, Gao, J. | 登録日 | 2017-05-05 | 公開日 | 2018-01-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.911 Å) | 主引用文献 | "Head-to-Middle" and "Head-to-Tail" cis-Prenyl Transferases: Structure of Isosesquilavandulyl Diphosphate Synthase. Angew. Chem. Int. Ed. Engl., 57, 2018
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5YGK
| Crystal structure of a synthase from Streptomyces sp. CL190 with dmaspp | 分子名称: | Cyclolavandulyl diphosphate synthase, DIMETHYLALLYL S-THIOLODIPHOSPHATE, MAGNESIUM ION | 著者 | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-09-23 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | 主引用文献 | Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. Acs Catalysis, 8, 2018
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5YNW
| Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 in complex with DMASPP and INN | 分子名称: | 3-[(Z)-2-isocyanoethenyl]-1H-indole, DIMETHYLALLYL S-THIOLODIPHOSPHATE, GLYCEROL, ... | 著者 | Wang, J, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-10-25 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochem. Biophys. Res. Commun., 495, 2018
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5YGJ
| Crystal structure of a synthase from Streptomyces sp. CL190 | 分子名称: | Cyclolavandulyl diphosphate synthase | 著者 | Gao, J, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-09-23 | 公開日 | 2018-07-25 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.648 Å) | 主引用文献 | Catalytic Role of Conserved Asparagine, Glutamine, Serine, and Tyrosine Residues in Isoprenoid Biosynthesis Enzymes. Acs Catalysis, 8, 2018
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7EO7
| Crystal structure of HCoV-NL63 3C-like protease in complex with an inhibitor Shikonin | 分子名称: | 2-[(1R)-4-methyl-1-oxidanyl-pent-3-enyl]-5,8-bis(oxidanyl)naphthalene-1,4-dione, 3C-like proteinase | 著者 | Gao, H.X, Zhang, Y.T, Zhou, X.L, Zhong, F.L, Li, J, Zhang, J. | 登録日 | 2021-04-21 | 公開日 | 2021-10-20 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.24916625 Å) | 主引用文献 | Structure-Based Discovery and Structural Basis of a Novel Broad-Spectrum Natural Product against the Main Protease of Coronavirus. J.Virol., 96, 2022
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5YNT
| Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 | 分子名称: | DIMETHYLALLYL DIPHOSPHATE, GLYCEROL, IMIDAZOLE, ... | 著者 | Wang, J, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-10-25 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochem. Biophys. Res. Commun., 495, 2018
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5YNU
| Crystal structure of an aromatic prenyltransferase FAMD1 from Fischerella ambigua UTEX 1903 in complex with INN | 分子名称: | 3-[(Z)-2-isocyanoethenyl]-1H-indole, DIMETHYLALLYL DIPHOSPHATE, GLYCEROL, ... | 著者 | Wang, J, Liu, W.D, Chen, C.C, Guo, R.T. | 登録日 | 2017-10-25 | 公開日 | 2018-08-29 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural insight into a novel indole prenyltransferase in hapalindole-type alkaloid biosynthesis. Biochem. Biophys. Res. Commun., 495, 2018
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