2IUG
 
 | | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain | | Descriptor: | PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY ALPHA SUBUNIT | | Authors: | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | | Deposit date: | 2006-06-03 | | Release date: | 2006-06-06 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Crystal Structure of the Pi 3-Kinase P85 Amino-Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
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2IUI
 | | Crystal structure of the PI3-kinase p85 N-terminal SH2 domain in complex with PDGFR phosphotyrosyl peptide | | Descriptor: | Phosphatidylinositol 3-kinase regulatory subunit alpha, Platelet-derived growth factor receptor beta | | Authors: | Nolte, R.T, Eck, M.J, Schlessinger, J, Shoelson, S.E, Harrison, S.C. | | Deposit date: | 2006-06-03 | | Release date: | 2006-06-06 | | Last modified: | 2024-11-20 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of the Pi 3-Kinase P85 Amino- Terminal Sh2 Domain and its Phosphopeptide Complexes
Nat.Struct.Biol., 3, 1996
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6J0G
 | | Crystal structure of intracellular B30.2 domain of BTN3A3 mutant in complex with HMBPP | | Descriptor: | (2E)-4-hydroxy-3-methylbut-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 3 member A3 | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-12-24 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
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6J06
 | | Crystal structure of intracellular B30.2 domain of BTN3A1 in complex with HMBPP-08 | | Descriptor: | (2E)-3-(hydroxymethyl)-4-(4-methylphenyl)but-2-en-1-yl trihydrogen diphosphate, Butyrophilin subfamily 3 member A1, CALCIUM ION, ... | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-12-21 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
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6J03
 | | Crystal structure of a cyclase mutant in apo form | | Descriptor: | 12-epi-hapalindole U synthase, CALCIUM ION, amino({3-[(3S,8aS)-1,4-dioxooctahydropyrrolo[1,2-a]pyrazin-3-yl]propyl}amino)methaniminium | | Authors: | Tang, X.K, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2018-12-20 | | Release date: | 2019-12-25 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Structural insights into the calcium dependence of Stig cyclases.
Rsc Adv, 9, 2019
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8V9R
 | | Cryo-EM Structure of a Proteolytic ClpXP AAA+ Machine Poised to Unfold a Branched-Degron DHFR-ssrA Substrate Bound with MTX | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-dependent Clp protease ATP-binding subunit ClpX, ... | | Authors: | Ghanbarpour, A, Sauer, R.T, Davis, J.H. | | Deposit date: | 2023-12-09 | | Release date: | 2024-10-16 | | Last modified: | 2025-06-04 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | A proteolytic AAA+ machine poised to unfold protein substrates.
Nat Commun, 15, 2024
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6JJS
 | | Crystal structure of an enzyme from Penicillium herquei in condition2 | | Descriptor: | ACETATE ION, PhnH | | Authors: | Fen, Y, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-02-26 | | Release date: | 2020-01-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.62 Å) | | Cite: | Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei.
Biochem.Biophys.Res.Commun., 516, 2019
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6JJT
 | | Crystal structure of an enzyme from Penicillium herquei in condition1 | | Descriptor: | CITRIC ACID, DI(HYDROXYETHYL)ETHER, PhnH | | Authors: | Fen, Y, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-02-26 | | Release date: | 2020-01-01 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.33 Å) | | Cite: | Crystal structure and proposed mechanism of an enantioselective hydroalkoxylation enzyme from Penicillium herquei.
Biochem.Biophys.Res.Commun., 516, 2019
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6ITA
 | | Crystal structure of intracellular B30.2 domain of BTN3A1 mutant | | Descriptor: | Butyrophilin subfamily 3 member A1 | | Authors: | Yang, Y.Y, Liu, W.D, Cai, N.N, Chen, C.C, Guo, R.T, Zhang, Y.H. | | Deposit date: | 2018-11-20 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.2 Å) | | Cite: | A Structural Change in Butyrophilin upon Phosphoantigen Binding Underlies Phosphoantigen-Mediated V gamma 9V delta 2 T Cell Activation.
Immunity, 50, 2019
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6J8V
 | | Structure of MOEN5-SSO7D fusion protein in complex with ligand 2 | | Descriptor: | FARNESYL, MoeN5,DNA-binding protein 7d | | Authors: | Ko, T.P, Zhang, L.L, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-01-21 | | Release date: | 2019-04-17 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Complex structures of MoeN5 with substrate analogues suggest sequential catalytic mechanism.
Biochem. Biophys. Res. Commun., 511, 2019
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6KA3
 | | Crystal structure of a Thebaine synthase from Papaver somniferum | | Descriptor: | PALMITIC ACID, SULFATE ION, Thebaine synthase 2 | | Authors: | Xue, J, Yu, X.J, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-06-20 | | Release date: | 2020-06-24 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.951 Å) | | Cite: | Structural insights into thebaine synthase 2 catalysis.
Biochem.Biophys.Res.Commun., 529, 2020
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4TSR
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6KA2
 | | Crystal structure of a Thebaine synthase from Papaver somniferum in complex with TBN | | Descriptor: | (4R,7aR,12bS)-7,9-dimethoxy-3-methyl-2,4,7a,13-tetrahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline, Thebaine synthase 2 | | Authors: | Xue, J, Yu, X.J, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-06-20 | | Release date: | 2020-06-24 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Structural insights into thebaine synthase 2 catalysis.
Biochem.Biophys.Res.Commun., 529, 2020
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6KQX
 | | Crystal structure of Yijc from B. subtilis in complex with UDP | | Descriptor: | URIDINE-5'-DIPHOSPHATE, Uncharacterized UDP-glucosyltransferase YjiC | | Authors: | Hu, Y.M, Dai, L.H, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-08-20 | | Release date: | 2020-09-30 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Structural dissection of unnatural ginsenoside-biosynthetic UDP-glycosyltransferase Bs-YjiC from Bacillus subtilis for substrate promiscuity.
Biochem.Biophys.Res.Commun., 534, 2021
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6LAA
 | | Crystal structure of full-length CYP116B46 from Tepidiphilus thermophilus | | Descriptor: | 1,2-ETHANEDIOL, CARBONATE ION, Cytochrome P450, ... | | Authors: | Zhang, L.L, Ko, T.P, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | Deposit date: | 2019-11-12 | | Release date: | 2020-06-10 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.13 Å) | | Cite: | Structural insight into the electron transfer pathway of a self-sufficient P450 monooxygenase.
Nat Commun, 11, 2020
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3DDW
 | | Crystal structure of glycogen phosphorylase complexed with an anthranilimide based inhibitor GSK055 | | Descriptor: | (2S)-{[(3-{[(2-chloro-6-methylphenyl)carbamoyl]amino}naphthalen-2-yl)carbonyl]amino}(phenyl)ethanoic acid, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | Authors: | Nolte, R.T. | | Deposit date: | 2008-06-06 | | Release date: | 2009-01-27 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg.Med.Chem.Lett., 19, 2009
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3DDS
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3DD1
 | | Crystal structure of glycogen phophorylase complexed with an anthranilimide based inhibitor GSK254 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-cyclohexyl-N-[(3-{[(2,4,6-trimethylphenyl)carbamoyl]amino}naphthalen-2-yl)carbonyl]-D-alanine, ... | | Authors: | Nolte, R.T. | | Deposit date: | 2008-06-04 | | Release date: | 2009-04-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.57 Å) | | Cite: | Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy.
Bioorg.Med.Chem.Lett., 19, 2009
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6UC8
 | | Guanine riboswitch bound to 8-aminoguanine | | Descriptor: | 8-AMINOGUANINE, ACETATE ION, COBALT HEXAMMINE(III), ... | | Authors: | Matyjasik, M.M, Hall, S.D, Batey, R.T. | | Deposit date: | 2019-09-15 | | Release date: | 2020-07-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.898 Å) | | Cite: | High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch.
Molecules, 25, 2020
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6CIH
 | | Crystal structure of a group II intron lariat in the post-catalytic state | | Descriptor: | IRIDIUM HEXAMMINE ION, MAGNESIUM ION, RNA (5'-R(P*UP*GP*UP*UP*UP*AP*UP*UP*AP*AP*AP*AP*AP*C*-3'), ... | | Authors: | Chan, R.T, Peters, J.K, Robart, A.R, Wiryaman, T, Rajashankar, K.R, Toor, N. | | Deposit date: | 2018-02-23 | | Release date: | 2018-11-21 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.676 Å) | | Cite: | Structural basis for the second step of group II intron splicing.
Nat Commun, 9, 2018
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6UC9
 | | Guanine riboswitch bound to O6-cyclohexylmethyl guanine | | Descriptor: | 6-O-CYCLOHEXYLMETHYL GUANINE, ACETATE ION, COBALT HEXAMMINE(III), ... | | Authors: | Matyjasik, M.M, Batey, R.T. | | Deposit date: | 2019-09-15 | | Release date: | 2020-07-22 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.941 Å) | | Cite: | High Affinity Binding of N2-Modified Guanine Derivatives Significantly Disrupts the Ligand Binding Pocket of the Guanine Riboswitch.
Molecules, 25, 2020
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3DS7
 | | Structure of an RNA-2'-deoxyguanosine complex | | Descriptor: | 2'-DEOXY-GUANOSINE, 67-MER, ACETATE ION, ... | | Authors: | Edwards, A.L, Batey, R.T. | | Deposit date: | 2008-07-11 | | Release date: | 2009-02-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | A structural basis for the recognition of 2'-deoxyguanosine by the purine riboswitch.
J.Mol.Biol., 385, 2009
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6U0Q
 | | Transthyretin in complex with (E)-5,5'-(ethene-1,2-diyl)bis(1,1-dihydroxy-3-oxo-1,3-dihydrobenzo[c][1,2]oxaborol-1-uide) | | Descriptor: | 3-[(~{E})-2-[7,7-bis(oxidanyl)-9-oxidanylidene-8-oxa-7-boranuidabicyclo[4.3.0]nona-1,3,5-trien-3-yl]ethenyl]-7,7-bis(oxidanyl)-8-oxa-7-boranuidabicyclo[4.3.0]nona-1(6),2,4-trien-9-one, Transthyretin | | Authors: | Windsor, I.W, Graham, B.J, Raines, R.T. | | Deposit date: | 2019-08-14 | | Release date: | 2021-01-27 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Boronic acid with high oxidative stability and utility in biological contexts.
Proc.Natl.Acad.Sci.USA, 118, 2021
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3DNJ
 | | The structure of the Caulobacter crescentus ClpS protease adaptor protein in complex with a N-end rule peptide | | Descriptor: | ATP-dependent Clp protease adapter protein clpS, MAGNESIUM ION, synthetic N-end rule peptide | | Authors: | Wang, K, Roman-Hernandez, G, Grant, R.A, Sauer, R.T, Baker, T.A. | | Deposit date: | 2008-07-02 | | Release date: | 2008-11-18 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | The molecular basis of N-end rule recognition.
Mol.Cell, 32, 2008
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6UBU
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