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8DRX
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BU of 8drx by Molmil
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp10-nsp11 (C10) cut site sequence (form 2)
Descriptor: Fusion protein of 3C-like proteinase nsp5 and nsp10-nsp11 (C10) cut site, SODIUM ION
Authors:Lee, J, Kenward, C, Worrall, L.J, Vuckovic, M, Paetzel, M, Strynadka, N.C.J.
Deposit date:2022-07-21
Release date:2022-09-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.
Nat Commun, 13, 2022
8DRS
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BU of 8drs by Molmil
Product structure of SARS-CoV-2 Mpro C145A mutant in complex with nsp6-nsp7 (C6) cut site sequence
Descriptor: 3C-like proteinase nsp5
Authors:Lee, J, Kenward, C, Worrall, L.J, Vuckovic, M, Paetzel, M, Strynadka, N.C.J.
Deposit date:2022-07-21
Release date:2022-09-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:X-ray crystallographic characterization of the SARS-CoV-2 main protease polyprotein cleavage sites essential for viral processing and maturation.
Nat Commun, 13, 2022
8CZ7
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BU of 8cz7 by Molmil
Crystal structure of SARS-CoV-2 Mpro with compound C2
Descriptor: 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide
Authors:Worrall, L.J, Lee, J, Strynadka, N.C.J.
Deposit date:2022-05-24
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2 Å)
Cite:A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
8CYZ
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BU of 8cyz by Molmil
Crystal structure of SARS-CoV-2 Mpro with compound C4
Descriptor: 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-[4-(methylsulfanyl)phenyl]acetamide
Authors:Worrall, L.J, Lee, J, Strynadka, N.C.J.
Deposit date:2022-05-24
Release date:2023-08-30
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
8CYU
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BU of 8cyu by Molmil
Crystal structure of SARS-CoV-2 Mpro with compound C5
Descriptor: 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(isoquinolin-4-yl)acetamide
Authors:Worrall, L.J, Lee, J, Strynadka, N.C.J.
Deposit date:2022-05-24
Release date:2023-08-30
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
8CZ4
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BU of 8cz4 by Molmil
Crystal structure of SARS-CoV-2 Mpro with compound C3
Descriptor: 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide
Authors:Worrall, L.J, Lee, J, Strynadka, N.C.J.
Deposit date:2022-05-24
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
8EXS
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BU of 8exs by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.3 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXR
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BU of 8exr by Molmil
Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain
Descriptor: (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ...
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXT
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BU of 8ext by Molmil
Cryo-EM structure of S. aureus BlaR1 F284A mutant in complex with ampicillin
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Alexander, J.A.N, Hu, J, Worrall, L.J, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXQ
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BU of 8exq by Molmil
Cryo-EM structure of S. aureus BlaR1 with C1 symmetry
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.9 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
8EXP
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BU of 8exp by Molmil
Cryo-EM structure of S. aureus BlaR1 with C2 symmetry
Descriptor: Beta-lactam sensor/signal transducer BlaR1, ZINC ION
Authors:Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2022-10-25
Release date:2023-01-11
Last modified:2024-06-19
Method:ELECTRON MICROSCOPY (4.2 Å)
Cite:Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
2YK4
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BU of 2yk4 by Molmil
Structure of Neisseria LOS-specific sialyltransferase (NST).
Descriptor: 1,2-ETHANEDIOL, 2-(2-{2-[2-(2-{2-[2-(2-{2-[4-(1,1,3,3-TETRAMETHYL-BUTYL)-PHENOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOX Y}-ETHOXY)-ETHANOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, ...
Authors:Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2011-05-25
Release date:2011-08-31
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis
J.Biol.Chem., 286, 2011
2YK5
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BU of 2yk5 by Molmil
Structure of Neisseria LOS-specific sialyltransferase (NST), in complex with CMP.
Descriptor: 1,2-ETHANEDIOL, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE, ...
Authors:Lin, L.Y.C, Rakic, B, Chiu, C.P.C, Lameignere, E, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2011-05-25
Release date:2011-08-31
Last modified:2019-09-25
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structure and Mechanism of the Lipooligosaccharide Sialyltransferase from Neisseria Meningitidis
J.Biol.Chem., 286, 2011
2WNB
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BU of 2wnb by Molmil
Crystal Structure of a Mammalian Sialyltransferase in complex with disaccharide and CMP
Descriptor: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, CYTIDINE-5'-MONOPHOSPHATE, HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM, ...
Authors:Rao, F.V, Rich, J.R, Raikic, B, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-07-08
Release date:2009-10-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural Insight Into Mammalian Sialyltransferases.
Nat.Struct.Mol.Biol., 16, 2009
2WLD
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BU of 2wld by Molmil
Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, POLYSIALIC ACID O-ACETYLTRANSFERASE
Authors:Lee, H.J, Rakic, B, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-06-23
Release date:2009-07-07
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase Oatwy from Neisseria Meningitidis.
J.Biol.Chem., 284, 2009
2WQQ
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BU of 2wqq by Molmil
Crystallographic analysis of monomeric CstII
Descriptor: ALPHA-2,3-/2,8-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE-3-FLUORO-N-ACETYL-NEURAMINIC ACID, DI(HYDROXYETHYL)ETHER
Authors:Chan, P.H.W, Lairson, L.L, Lee, H.J, Wakarchuk, W.W, Strynadka, N.C.J, Withers, S.G, McIntosh, L.P.
Deposit date:2009-08-25
Release date:2009-10-27
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:NMR Spectroscopic Characterization of the Sialyltransferase Cstii from Camplyobacter Jejuni: Histidine 188 is the General Base.
Biochemistry, 48, 2009
2X4A
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BU of 2x4a by Molmil
Crystal structure of the C-terminal domain of InvA
Descriptor: 3-CYCLOHEXYL-1-PROPYLSULFONIC ACID, INVASION PROTEIN INVA, PHOSPHATE ION
Authors:Worrall, L.J, Vuckovic, M, Strynadka, N.C.J.
Deposit date:2010-01-28
Release date:2010-05-05
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.54 Å)
Cite:Crystal Structure of the C-Terminal Domain of the Salmonella Type III Secretion System Export Apparatus Protein Inva.
Protein Sci., 19, 2010
2WNF
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BU of 2wnf by Molmil
Crystal Structure of a Mammalian Sialyltransferase in complex with Gal-beta-1-3GalNAc-ortho-nitrophenol
Descriptor: CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE-ALPHA-2,3-SIALYLTRANSFERASE, HYDROXY(2-HYDROXYPHENYL)OXOAMMONIUM, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-alpha-D-galactopyranose
Authors:Rao, F.V, Rich, J.R, Raikic, B, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-07-09
Release date:2009-10-13
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Structural Insight Into Mammalian Sialyltransferases.
Nat.Struct.Mol.Biol., 16, 2009
2WML
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BU of 2wml by Molmil
Crystal Structure of a Mammalian Sialyltransferase
Descriptor: CHLORIDE ION, CMP-N-ACETYLNEURAMINATE-BETA-GALACTOSAMIDE -ALPHA-2,3-SIALYLTRANSFERASE, GLYCEROL
Authors:Rao, F.V, Rich, J.R, Raikic, B, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-07-01
Release date:2009-10-13
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural Insight Into Mammalian Sialyltransferases.
Nat.Struct.Mol.Biol., 16, 2009
2WLC
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BU of 2wlc by Molmil
Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, PHOSPHATE ION, ...
Authors:Lee, H.J, Rakic, B, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-06-23
Release date:2009-06-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase Oatwy from Neisseria Meningitidis.
J.Biol.Chem., 284, 2009
2X63
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BU of 2x63 by Molmil
Crystal structure of the sialyltransferase CST-II N51A in complex with CMP
Descriptor: 1,2-ETHANEDIOL, ALPHA-2,3-/2,8-SIALYLTRANSFERASE, CYTIDINE-5'-MONOPHOSPHATE
Authors:Lee, H.J, Lairson, L.L, Rich, J.R, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2010-02-14
Release date:2011-02-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
2X62
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BU of 2x62 by Molmil
CRYSTAL STRUCTURE OF THE SIALYLTRANSFERASE CST-II Y81F IN COMPLEX WITH CMP
Descriptor: 1,2-ETHANEDIOL, ALPHA-2,3-/2,8-SIALYLTRANSFERASE, N3-PROTONATED CYTIDINE-5'-MONOPHOSPHATE
Authors:Lee, H.J, Lairson, L.L, Rich, J.R, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2010-02-14
Release date:2011-02-23
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural and Kinetic Analysis of Substrate Binding to the Sialyltransferase Cst-II from Campylobacter Jejuni.
J.Biol.Chem., 286, 2011
2WLF
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BU of 2wlf by Molmil
Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, ACETYL COENZYME *A, ...
Authors:Lee, H.J, Rakic, B, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-06-23
Release date:2009-06-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase Oatwy from Neisseria Meningitidis.
J.Biol.Chem., 284, 2009
2WLE
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BU of 2wle by Molmil
Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, COENZYME A, ...
Authors:Lee, H.J, Rakic, B, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-06-23
Release date:2009-06-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.19 Å)
Cite:Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase Oatwy from Neisseria Meningitidis.
J.Biol.Chem., 284, 2009
2WLG
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BU of 2wlg by Molmil
Crystallographic analysis of the polysialic acid O-acetyltransferase OatWY
Descriptor: 1,2-ETHANEDIOL, ACETATE ION, POLYSIALIC ACID O-ACETYLTRANSFERASE, ...
Authors:Lee, H.J, Rakic, B, Gilbert, M, Wakarchuk, W.W, Withers, S.G, Strynadka, N.C.J.
Deposit date:2009-06-23
Release date:2009-06-30
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and Kinetic Characterizations of the Polysialic Acid O-Acetyltransferase Oatwy from Neisseria Meningitidis.
J.Biol.Chem., 284, 2009

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