9KRD
 
 | | CRYSTAL STRUCTURE OF REDUCED CYTOCHROME C6 FROM SYNECHOCOCCUS ELONGATUS PCC 7942 | | Descriptor: | Cytochrome c6, HEME C, SULFATE ION | | Authors: | Zhang, B.T, Liu, S.W, Xu, Y.C, Sheng, W, Gong, Y, Cao, P. | | Deposit date: | 2024-11-27 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | A High-Resolution Crystallographic Study of Cytochrome c6: Structural Basis for Electron Transfer in Cyanobacterial Photosynthesis.
Int J Mol Sci, 26, 2025
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9KRC
 | | CRYSTAL STRUCTURE OF OXIDIIZED CYTOCHROME C6 FROM SYNECHOCOCCUS ELONGATUS PCC 7942 | | Descriptor: | Cytochrome c6, HEME C, SULFATE ION | | Authors: | Zhang, B.T, Liu, S.W, Xu, Y.C, Sheng, W, Gong, Y, Cao, P. | | Deposit date: | 2024-11-27 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | A High-Resolution Crystallographic Study of Cytochrome c6: Structural Basis for Electron Transfer in Cyanobacterial Photosynthesis.
Int J Mol Sci, 26, 2025
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9KRR
 | | CRYSTAL STRUCTURE OF REDUCED CYTOCHROME C6 FROM Synechocystis PCC 6803 | | Descriptor: | Cytochrome c6, HEME C, IODIDE ION, ... | | Authors: | Zhang, B.T, Liu, S.W, Xu, Y.C, Sheng, W, Gong, Y, Cao, P. | | Deposit date: | 2024-11-28 | | Release date: | 2025-01-29 | | Last modified: | 2025-02-05 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | A High-Resolution Crystallographic Study of Cytochrome c6: Structural Basis for Electron Transfer in Cyanobacterial Photosynthesis.
Int J Mol Sci, 26, 2025
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7CGW
 | | Complex structure of PD-1 and tislelizumab Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of tislelizumab Fab, Light chain of tislelizumab Fab, ... | | Authors: | Hong, Y, Feng, Y.C, Liu, Y. | | Deposit date: | 2020-07-02 | | Release date: | 2021-04-07 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Tislelizumab uniquely binds to the CC' loop of PD-1 with slow-dissociated rate and complete PD-L1 blockage.
Febs Open Bio, 11, 2021
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9JRI
 | | outward-open hSLC19A1 + 5-MTHF | | Descriptor: | 5-METHYL-5,6,7,8-TETRAHYDROFOLIC ACID, Soluble cytochrome b562,Reduced folate transporter,fusion protein | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-29 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.43 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9JRK
 | | outward-open hSLC19A1 + MTX | | Descriptor: | METHOTREXATE, Soluble cytochrome b562,Reduced folate transporter,fusion protein | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-29 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.44 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9JOZ
 | | outward-open hSLC19A1 | | Descriptor: | Soluble cytochrome b562,Reduced folate transporter,fusion protein | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-25 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (2.94 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9JRM
 | | outward-open hSLC19A1 + 2'3'-CDAS | | Descriptor: | (1~{R},3~{S},6~{R},8~{R},9~{R},10~{S},12~{S},15~{R},17~{R},18~{R})-8,17-bis(6-aminopurin-9-yl)-3,12-bis(oxidanylidene)-3,12-bis(sulfanyl)-2,4,7,11,13,16-hexaoxa-3$l^{5},12$l^{5}-diphosphatricyclo[13.2.1.0^{6,10}]octadecane-9,18-diol, Soluble cytochrome b562,Reduced folate transporter,Soluble cytochrome b562,Reduced folate transporter,fusion protein | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-29 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.34 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9JRL
 | | outward-open hSLC19A1 + PT523 | | Descriptor: | N-(4-CARBOXY-4-{4-[(2,4-DIAMINO-PTERIDIN-6-YLMETHYL)-AMINO]-BENZOYLAMINO}-BUTYL)-PHTHALAMIC ACID, Soluble cytochrome b562,Reduced folate transporter,fusion protein | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-29 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.25 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9JRN
 | | outward-open hSLC19A1 + TPP | | Descriptor: | Soluble cytochrome b562,Reduced folate transporter,fusion protein, THIAMINE DIPHOSPHATE | | Authors: | Zhang, Q.X, Liu, K.X, Gao, P. | | Deposit date: | 2024-09-29 | | Release date: | 2025-02-26 | | Last modified: | 2025-04-23 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport.
Nat Commun, 16, 2025
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9IXX
 | | Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4 | | Descriptor: | (5~{S},6~{R},7~{E},9~{E},11~{Z},14~{Z})-6-[(2~{R})-2-azanyl-3-(2-hydroxy-2-oxoethylamino)-3-oxidanylidene-propyl]sulfanyl-5-oxidanyl-icosa-7,9,11,14-tetraenoic acid, Cysteinyl leukotriene receptor 2, G-alpha q, ... | | Authors: | Jiang, M, Xu, Y, Yin, W. | | Deposit date: | 2024-07-29 | | Release date: | 2025-04-02 | | Last modified: | 2025-04-30 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Structural basis of the cysteinyl leukotriene receptor type 2 activation by LTD4.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZCS
 | | Crystal structure of the MBP-MCL1 complex with highly selective and potent Cyclic peptide inhibitor | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Induced myeloid leukemia cell differentiation protein Mcl-1, TYR-LEU-LEU-PHE-TRP-ARG-ASP-GLU-LEU-ILE-LEU-LEU-CCJ-NH2, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | | Authors: | Li, F.W. | | Deposit date: | 2024-04-30 | | Release date: | 2025-03-19 | | Last modified: | 2025-04-02 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | De novo discovery of a molecular glue-like macrocyclic peptide that induces MCL1 homodimerization.
Proc.Natl.Acad.Sci.USA, 122, 2025
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8ZVX
 | | Crystal structure of snFPITE-n2 | | Descriptor: | GLYCEROL, PENTAETHYLENE GLYCOL, SULFATE ION, ... | | Authors: | Chen, X, Yang, H. | | Deposit date: | 2024-06-12 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus.
Nat Commun, 16, 2025
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8ZVS
 | | Crystal structure of snFPITE-n1 | | Descriptor: | SULFATE ION, phenylmethanesulfonic acid, snFPITE-n1 | | Authors: | Chen, X, Yang, H, Hu, Y.L. | | Deposit date: | 2024-06-12 | | Release date: | 2025-04-02 | | Last modified: | 2025-05-07 | | Method: | X-RAY DIFFRACTION (1.987 Å) | | Cite: | A facultative plasminogen-independent thrombolytic enzyme from Sipunculus nudus.
Nat Commun, 16, 2025
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8J9G
 | | CrtSPARTA hetero-dimer bound with guide-target, state 1 | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-03 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J8H
 | | SPARTA monomer bound with guide-target, state 2 | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-01 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J84
 | | Short ago complexed with TIR-APAZ | | Descriptor: | Piwi domain-containing protein, TIR domain-containing protein | | Authors: | Guo, L.J, Huang, P.P, Li, Z.X, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-04-30 | | Release date: | 2024-03-13 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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8J9P
 | | SPARTA dimer bound with guide-target | | Descriptor: | DNA (25-MER), MAGNESIUM ION, Piwi domain-containing protein, ... | | Authors: | Li, Z.X, Guo, L.J, Huang, P.P, Xiao, Y.B, Chen, M.R. | | Deposit date: | 2023-05-04 | | Release date: | 2024-03-06 | | Last modified: | 2024-04-10 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Auto-inhibition and activation of a short Argonaute-associated TIR-APAZ defense system.
Nat.Chem.Biol., 20, 2024
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7UOM
 | | Endogenous dihydrolipoamide acetyltransferase (E2) core of pyruvate dehydrogenase complex from bovine kidney | | Descriptor: | Acetyltransferase component of pyruvate dehydrogenase complex | | Authors: | Liu, S, Xia, X, Zhen, J, Li, Z.H, Zhou, Z.H. | | Deposit date: | 2022-04-13 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.8 Å) | | Cite: | Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney.
Cell Discov, 8, 2022
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7UOL
 | | Endogenous dihydrolipoamide succinyltransferase (E2) core of 2-oxoglutarate dehydrogenase complex from bovine kidney | | Descriptor: | Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial | | Authors: | Liu, S, Xia, X, Zhen, J, Li, Z.H, Zhou, Z.H. | | Deposit date: | 2022-04-13 | | Release date: | 2022-11-30 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures and comparison of endogenous 2-oxoglutarate and pyruvate dehydrogenase complexes from bovine kidney.
Cell Discov, 8, 2022
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4ISS
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4KCG
 | | Human dCK C4S-S74E mutant in complex with UDP and the DI-39 inhibitor | | Descriptor: | Deoxycytidine kinase, N-{2-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]ethyl}methanesulfonamide, URIDINE-5'-DIPHOSPHATE | | Authors: | Nomme, J, Lavie, A. | | Deposit date: | 2013-04-24 | | Release date: | 2014-03-12 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication.
J.Exp.Med., 211, 2014
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4JLK
 | | Human dCK C4S-S74E mutant in complex with UDP and the F2.2.1 inhibitoR (2-[({2-[3-(2-FLUOROETHOXY)-4-METHOXYPHENYL]-5-METHYL-1,3-THIAZOL-4-YL}METHYL)SULFANYL]PYRIMIDINE-4,6-DIAMINE) | | Descriptor: | 2-[({2-[3-(2-fluoroethoxy)-4-methoxyphenyl]-5-methyl-1,3-thiazol-4-yl}methyl)sulfanyl]pyrimidine-4,6-diamine, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | Authors: | Nomme, J, Lavie, A. | | Deposit date: | 2013-03-12 | | Release date: | 2013-09-18 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.89 Å) | | Cite: | Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
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4IST
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4L5B
 | | Human dCK C4S-S74E mutant in complex with UDP and the DI-43 inhibitor | | Descriptor: | 1-[5-(4-{[(4,6-diaminopyrimidin-2-yl)sulfanyl]methyl}-5-propyl-1,3-thiazol-2-yl)-2-methoxyphenoxy]-2-methylpropan-2-ol, Deoxycytidine kinase, URIDINE-5'-DIPHOSPHATE | | Authors: | Nomme, J, Lavie, A. | | Deposit date: | 2013-06-10 | | Release date: | 2013-09-18 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography.
J.Med.Chem., 56, 2013
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