8Q63
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![BU of 8q63 by Molmil](/molmil-images/mine/8q63) | Cryo-EM structure of IC8', a second state of yeast mitochondrial RNA polymerase transcription initiation complex with 8-mer RNA, pppGpGpUpApApApUpG | Descriptor: | DNA-directed RNA polymerase, mitochondrial, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Goovaerts, Q, Shen, J, Patel, S.S, Das, K. | Deposit date: | 2023-08-10 | Release date: | 2023-08-30 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structures illustrate step-by-step mitochondrial transcription initiation. Nature, 622, 2023
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5X3V
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![BU of 5x3v by Molmil](/molmil-images/mine/5x3v) | Structure of human SHMT2 protein mutant | Descriptor: | SULFATE ION, Serine hydroxymethyltransferase, mitochondrial | Authors: | Li, J, Sheng, J. | Deposit date: | 2017-02-09 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of human SHMT2 protein mutant To Be Published
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5BNN
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![BU of 5bnn by Molmil](/molmil-images/mine/5bnn) | Crystal structure of human enterovirus D68 in complex with 6'SL | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | Authors: | Liu, Y, Sheng, J, Meng, G, Xiao, C, Rossmann, M.G. | Deposit date: | 2015-05-26 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Sialic acid-dependent cell entry of human enterovirus D68. Nat Commun, 6, 2015
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5U0Q
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![BU of 5u0q by Molmil](/molmil-images/mine/5u0q) | RNA-DNA heptamer duplex with one 2'-5'-linkage | Descriptor: | COBALT (II) ION, DNA/RNA (5'-R(*GP*GP*AP*GP*C)-D(P*T)-R(P*A)-3'), MAGNESIUM ION, ... | Authors: | Luo, Z, Sheng, J. | Deposit date: | 2016-11-26 | Release date: | 2017-11-29 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | RNA-DNA heptamer duplex with one 2'-5'-linkage To Be Published
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5TV5
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![BU of 5tv5 by Molmil](/molmil-images/mine/5tv5) | BioW from Aquifex aeoulicus | Descriptor: | 6-carboxyhexanoate--CoA ligase | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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5TV6
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![BU of 5tv6 by Molmil](/molmil-images/mine/5tv6) | A. aeolicus BioW with pimelate | Descriptor: | 6-carboxyhexanoate--CoA ligase, PIMELIC ACID | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.456 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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5TV8
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![BU of 5tv8 by Molmil](/molmil-images/mine/5tv8) | A. aeolicus BioW with AMP-CPP and pimelate | Descriptor: | 6-carboxyhexanoate--CoA ligase, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, MAGNESIUM ION, ... | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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5TVA
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![BU of 5tva by Molmil](/molmil-images/mine/5tva) | A. aeolicus BioW with AMP and CoA | Descriptor: | 6-carboxyhexanoate--CoA ligase, ADENOSINE MONOPHOSPHATE, COENZYME A | Authors: | Estrada, P, Manandhar, M, Dong, S.-H, Deveryshetty, J, Agarwal, V, Cronan, J.E, Nair, S.K. | Deposit date: | 2016-11-08 | Release date: | 2016-12-07 | Last modified: | 2017-05-31 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | The pimeloyl-CoA synthetase BioW defines a new fold for adenylate-forming enzymes. Nat. Chem. Biol., 13, 2017
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5BNP
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![BU of 5bnp by Molmil](/molmil-images/mine/5bnp) | Crystal structure of human enterovirus D68 in complex with 3'SLN | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | Authors: | Liu, Y, Sheng, J, Meng, G, Xiao, C, Rossmann, M.G. | Deposit date: | 2015-05-26 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Sialic acid-dependent cell entry of human enterovirus D68. Nat Commun, 6, 2015
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5BNO
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![BU of 5bno by Molmil](/molmil-images/mine/5bno) | Crystal structure of human enterovirus D68 in complex with 6'SLN | Descriptor: | Capsid protein VP1, Capsid protein VP2, Capsid protein VP3, ... | Authors: | Liu, Y, Sheng, J, Meng, G, Xiao, C, Rossmann, M.G. | Deposit date: | 2015-05-26 | Release date: | 2015-11-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Sialic acid-dependent cell entry of human enterovirus D68. Nat Commun, 6, 2015
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5TKO
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![BU of 5tko by Molmil](/molmil-images/mine/5tko) | RNA heptamer duplex with one 2'-5'-linkage | Descriptor: | COBALT (II) ION, RNA (5'-R(*GP*GP*AP*GP*CP*UP*A)-3'), RNA (5'-R(*UP*AP*GP*CP*UP*CP*C)-3') | Authors: | Luo, Z, Sheng, J. | Deposit date: | 2016-10-07 | Release date: | 2017-10-11 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | RNA heptamer duplex with one 2'-5'-linkage To Be Published
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5H99
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![BU of 5h99 by Molmil](/molmil-images/mine/5h99) | |
5H9I
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![BU of 5h9i by Molmil](/molmil-images/mine/5h9i) | Crystal structure of Geobacter metallireducens SMUG1 with xanthine | Descriptor: | BETA-MERCAPTOETHANOL, GLYCEROL, Geobacter metallireducens SMUG1, ... | Authors: | Xie, W, Cao, W, Zhang, Z, Shen, J. | Deposit date: | 2015-12-28 | Release date: | 2016-04-27 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.501 Å) | Cite: | Structural Basis of Substrate Specificity in Geobacter metallireducens SMUG1 Acs Chem.Biol., 11, 2016
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5H93
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![BU of 5h93 by Molmil](/molmil-images/mine/5h93) | |
5H98
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![BU of 5h98 by Molmil](/molmil-images/mine/5h98) | |
4KW0
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![BU of 4kw0 by Molmil](/molmil-images/mine/4kw0) | Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification | Descriptor: | DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*(1TW)P*CP*G)-3'), MAGNESIUM ION | Authors: | Jiang, S, Gan, J, Sheng, J, Sun, H, Huang, Z. | Deposit date: | 2013-05-23 | Release date: | 2013-07-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.49 Å) | Cite: | Structure of Dickerson-Drew Dodecamer with 2'-MeSe-ara-G modification TO BE PUBLISHED
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4NDZ
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![BU of 4ndz by Molmil](/molmil-images/mine/4ndz) | Structure of Maltose Binding Protein fusion to 2-O-Sulfotransferase with bound heptasaccharide and PAP | Descriptor: | ADENOSINE-3'-5'-DIPHOSPHATE, Maltose-binding periplasmic protein, Heparan sulfate 2-O-sulfotransferase 1 fusion, ... | Authors: | Liu, C, Sheng, J, Krahn, J.M, Perera, L, Xu, Y, Hsieh, P, Liu, J, Pedersen, L.C. | Deposit date: | 2013-10-28 | Release date: | 2014-03-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.45 Å) | Cite: | Deciphering the role of 2-O-sulfotransferase in regulating heparan sulfate biosynthesis To be Published
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5CP7
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![BU of 5cp7 by Molmil](/molmil-images/mine/5cp7) | Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides | Descriptor: | Heavy Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7, Light Chain of Antigen-Binding Fragment of Monoclonal Antibody of 4C7 | Authors: | Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X. | Deposit date: | 2015-07-21 | Release date: | 2015-08-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.01 Å) | Cite: | Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem., 91, 2019
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5CP3
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![BU of 5cp3 by Molmil](/molmil-images/mine/5cp3) | Crystal Structure of an Antigen-Binding Fragment of Monoclonal Antibody against Sulfonamides in Complex with Sulfathiazole | Descriptor: | 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, CALCIUM ION, GLYCEROL, ... | Authors: | Wang, Z, Shen, J, Li, C, Li, Y, Wen, K, Yu, X, Zhang, X. | Deposit date: | 2015-07-21 | Release date: | 2015-08-05 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Class-specific Monoclonal Antibodies and Dihydropteroate Synthase in Bioassays used for the Detection of Sulfonamides: Structural Insights into Recognition Diversity. Anal. Chem., 91, 2019
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5GSK
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![BU of 5gsk by Molmil](/molmil-images/mine/5gsk) | Crystal structure of duplex DNA3 in complex with Hg(II) and Sr(II) | Descriptor: | DNA (5'-D(*GP*GP*TP*CP*GP*TP*CP*C)-3'), MERCURY (II) ION, STRONTIUM ION | Authors: | Liu, H.H, Wang, R, Yao, Q.Q, Cheng, Y.Q, Yang, C, Luo, Q, Wu, B.X, Li, J.X, Ma, J.B, Sheng, J, Gan, J.H. | Deposit date: | 2016-08-16 | Release date: | 2017-02-08 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Flexibility and stabilization of HgII-mediated C:T and T:T base pairs in DNA duplex Nucleic Acids Res., 45, 2017
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2A9H
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![BU of 2a9h by Molmil](/molmil-images/mine/2a9h) | NMR structural studies of a potassium channel / charybdotoxin complex | Descriptor: | Voltage-gated potassium channel, charybdotoxin | Authors: | Yu, L, Sun, C, Song, D, Shen, J, Xu, N, Gunasekera, A, Hajduk, P.J, Olejniczak, E.T. | Deposit date: | 2005-07-11 | Release date: | 2006-01-10 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Nuclear magnetic resonance structural studies of a potassium channel-charybdotoxin complex. Biochemistry, 44, 2005
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5HNQ
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![BU of 5hnq by Molmil](/molmil-images/mine/5hnq) | |
2F7Z
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![BU of 2f7z by Molmil](/molmil-images/mine/2f7z) | Protein Kinase A bound to (R)-1-(1H-Indol-3-ylmethyl)-2-(2-pyridin-4-yl-[1,7]naphtyridin-5-yloxy)-ehylamine | Descriptor: | (1S)-1-(1H-INDOL-3-YLMETHYL)-2-(2-PYRIDIN-4-YL-[1,7]NAPHTYRIDIN-5-YLOXY)-EHYLAMINE, PKI, inhibitory peptide, ... | Authors: | Li, Q, Woods, K.W, Thomas, S, Zhu, G.D, Packard, G, Fisher, J, Li, T, Gong, J, Dinges, J, Song, X, Abrams, J, Luo, Y, Johnson, E.F, Shi, Y, Liu, X, Klinghofer, V, Des Jong, R, Oltersdorf, T, Stoll, V.S, Jakob, C.G, Rosenberg, S.H, Giranda, V.L. | Deposit date: | 2005-12-01 | Release date: | 2006-06-27 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Synthesis and structure-activity relationship of 3,4'-bispyridinylethylenes: discovery of a potent 3-isoquinolinylpyridine inhibitor of protein kinase B (PKB/Akt) for the treatment of cancer. Bioorg.Med.Chem.Lett., 16, 2006
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3BM0
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![BU of 3bm0 by Molmil](/molmil-images/mine/3bm0) | |
4AUA
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![BU of 4aua by Molmil](/molmil-images/mine/4aua) | Liganded X-ray crystal structure of cyclin dependent kinase 6 (CDK6) | Descriptor: | 1H-benzimidazol-2-yl(1H-pyrrol-2-yl)methanone, CYCLIN-DEPENDENT KINASE 6 | Authors: | Cho, Y.S, Angove, H, Brain, C, Chen, C.H.T, Cheng, R, Chopra, R, Chung, K, Congreve, M, Dagostin, C, Davis, D, Feltell, R, Giraldes, J, Hiscock, S, Kim, S, Kovats, S, Lagu, B, Lewry, K, Loo, A, Lu, Y, Luzzio, M, Maniara, W, Mcmenamin, R, Mortenson, P, Benning, R, O'Reilly, M, Rees, D, Shen, J, Smith, T, Wang, Y, Williams, G, Woolford, A, Wrona, W, Xu, M, Yang, F, Howard, S. | Deposit date: | 2012-05-15 | Release date: | 2013-02-06 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Fragment-Based Discovery of 7-Azabenzimidazoles as Potent, Highly Selective, and Orally Active CDK4/6 Inhibitors. ACS Med Chem Lett, 3, 2012
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