6E8U
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![BU of 6e8u by Molmil](/molmil-images/mine/6e8u) | Structure of the Mango-III (A10U) aptamer bound to TO1-Biotin | Descriptor: | 4-[(3-{2,16-dioxo-20-[(3aR,4R,6aS)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-1,3-benzothiazol-3-ium-2-yl)methyl]-1-methylquinolin-1-ium, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Trachman, R.J, Ferre-D'Amare, A.R. | Deposit date: | 2018-07-31 | Release date: | 2019-04-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nat. Chem. Biol., 15, 2019
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6E1V
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![BU of 6e1v by Molmil](/molmil-images/mine/6e1v) | Crystal structure of a class I PreQ1 riboswitch complexed with a synthetic compound 3: 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine | Descriptor: | 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine, RNA (33-MER) | Authors: | Numata, T, Connelly, C.M, Schneekloth, J.S, Ferre-D'Amare, A.R. | Deposit date: | 2018-07-10 | Release date: | 2019-04-10 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Synthetic ligands for PreQ1riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun, 10, 2019
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6E8S
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![BU of 6e8s by Molmil](/molmil-images/mine/6e8s) | Structure of the iMango-III aptamer bound to TO1-Biotin | Descriptor: | 4-[(3-{2-[(2-methoxyethyl)amino]-2-oxoethyl}-1,3-benzothiazol-3-ium-2-yl)methyl]-1-methylquinolin-1-ium, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Trachman, R.J, Ferre-D'Amare, A.R. | Deposit date: | 2018-07-31 | Release date: | 2019-04-17 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nat. Chem. Biol., 15, 2019
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6E80
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![BU of 6e80 by Molmil](/molmil-images/mine/6e80) | |
6E84
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![BU of 6e84 by Molmil](/molmil-images/mine/6e84) | Crystal structure of the Corn aptamer in complex with TO | Descriptor: | 1-methyl-4-[(Z)-(3-methyl-1,3-benzothiazol-2(3H)-ylidene)methyl]quinolin-1-ium, POTASSIUM ION, RNA (36-MER) | Authors: | Sjekloca, L, Ferre-D'Amare, A.R. | Deposit date: | 2018-07-27 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.901 Å) | Cite: | Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence. Cell Chem Biol, 26, 2019
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6E82
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![BU of 6e82 by Molmil](/molmil-images/mine/6e82) | |
6E81
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![BU of 6e81 by Molmil](/molmil-images/mine/6e81) | Crystal structure of the Corn aptamer in complex with ThT | Descriptor: | 2-[4-(dimethylamino)phenyl]-3,6-dimethyl-1,3-benzothiazol-3-ium, POTASSIUM ION, RNA (36-MER) | Authors: | Sjekloca, L, Ferre-D'Amare, A.R. | Deposit date: | 2018-07-27 | Release date: | 2019-07-31 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.721 Å) | Cite: | Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence. Cell Chem Biol, 26, 2019
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5V3F
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![BU of 5v3f by Molmil](/molmil-images/mine/5v3f) | Co-crystal structure of the fluorogenic RNA Mango | Descriptor: | 4-{[(2S)-3-{2,16-dioxo-20-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-2,3-dihydro-1,3-benzothiazol-2-yl]methyl}-1-methylquinolin-1-ium, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Trachman, R.J, Ferre-D'Amare, A.R. | Deposit date: | 2017-03-07 | Release date: | 2017-05-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for high-affinity fluorophore binding and activation by RNA Mango. Nat. Chem. Biol., 13, 2017
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2H0Z
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![BU of 2h0z by Molmil](/molmil-images/mine/2h0z) | |
2HO7
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![BU of 2ho7 by Molmil](/molmil-images/mine/2ho7) | |
2HOK
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![BU of 2hok by Molmil](/molmil-images/mine/2hok) | |
2HOL
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![BU of 2hol by Molmil](/molmil-images/mine/2hol) | |
2HOO
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![BU of 2hoo by Molmil](/molmil-images/mine/2hoo) | |
2GCV
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![BU of 2gcv by Molmil](/molmil-images/mine/2gcv) | |
2GCS
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![BU of 2gcs by Molmil](/molmil-images/mine/2gcs) | |
2H0W
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![BU of 2h0w by Molmil](/molmil-images/mine/2h0w) | |
2H0X
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![BU of 2h0x by Molmil](/molmil-images/mine/2h0x) | |
2H0S
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![BU of 2h0s by Molmil](/molmil-images/mine/2h0s) | |
2HO6
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![BU of 2ho6 by Molmil](/molmil-images/mine/2ho6) | |
2HOM
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![BU of 2hom by Molmil](/molmil-images/mine/2hom) | |
2HOJ
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![BU of 2hoj by Molmil](/molmil-images/mine/2hoj) | |
2HOP
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![BU of 2hop by Molmil](/molmil-images/mine/2hop) | |
6OD9
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![BU of 6od9 by Molmil](/molmil-images/mine/6od9) | Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser | Descriptor: | AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, CESIUM ION, MAGNESIUM ION, ... | Authors: | Jones, C.P, Tran, B, Ferre-D'Amare, A.R. | Deposit date: | 2019-03-26 | Release date: | 2019-07-17 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.102 Å) | Cite: | Co-crystal structure of the Fusobacterium ulcerans ZTP riboswitch using an X-ray free-electron laser. Acta Crystallogr.,Sect.F, 75, 2019
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3OT0
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![BU of 3ot0 by Molmil](/molmil-images/mine/3ot0) | |
5VHE
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![BU of 5vhe by Molmil](/molmil-images/mine/5vhe) | DHX36 in complex with the c-Myc G-quadruplex | Descriptor: | DEAH (Asp-Glu-Ala-His) box polypeptide 36, DNA (5'-D(*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*TP*TP*TP*TP*TP*T)-3'), POTASSIUM ION | Authors: | Chen, M, Ferre-D'Amare, A. | Deposit date: | 2017-04-13 | Release date: | 2018-06-13 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (3.793 Å) | Cite: | Structural basis of G-quadruplex unfolding by the DEAH/RHA helicase DHX36. Nature, 558, 2018
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