5V3F

Co-crystal structure of the fluorogenic RNA Mango

Summary for 5V3F

• Entry DOI: 10.2210/pdb5v3f/pdb
• Descriptor: RNA (31-MER), POTASSIUM ION, 4-{[(2S)-3-{2,16-dioxo-20-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-6,9,12-trioxa-3,15-diazaicosan-1-yl}-2,3-dihydro-1,3-benzothiazol-2-yl]methyl}-1-methylquinolin-1-ium, ... (5 entities in total)
• Functional Keywords: quadruplex fluorescent rna, rna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 22428.93

Authors

Trachman, R.J.,Ferre-D'Amare, A.R. (deposition date: 2017-03-07, release date: 2017-05-24, Last modification date: 2024-03-06)

• Primary citation: Trachman, R.J.,Demeshkina, N.A.,Lau, M.W.L.,Panchapakesan, S.S.S.,Jeng, S.C.Y.,Unrau, P.J.,Ferre-D'Amare, A.R.; Structural basis for high-affinity fluorophore binding and activation by RNA Mango.; Nat. Chem. Biol., 13:807-813, 2017; PubMed: 28553947; DOI: 10.1038/nchembio.2392

Experimental method

X-RAY DIFFRACTION (1.7 Å)