1LKI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1lki by Molmil](/molmil-images/mine/1lki) | THE CRYSTAL STRUCTURE AND BIOLOGICAL FUNCTION OF LEUKEMIA INHIBITORY FACTOR: IMPLICATIONS FOR RECEPTOR BINDING | Descriptor: | LEUKEMIA INHIBITORY FACTOR | Authors: | Robinson, R.C, Grey, L.M, Staunton, D, Stuart, D.I, Heath, J.K, Jones, E.Y. | Deposit date: | 1994-12-12 | Release date: | 1995-03-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell(Cambridge,Mass.), 77, 1994
|
|
1LUJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1luj by Molmil](/molmil-images/mine/1luj) | Crystal Structure of the Beta-catenin/ICAT Complex | Descriptor: | Beta-catenin-interacting protein 1, Catenin beta-1 | Authors: | Graham, T.A, Clements, W.K, Kimelman, D, Xu, W. | Deposit date: | 2002-05-22 | Release date: | 2002-10-16 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The crystal structure of the beta-catenin/ICAT complex reveals the inhibitory mechanism of ICAT. Mol.Cell, 10, 2002
|
|
5ZJZ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zjz by Molmil](/molmil-images/mine/5zjz) | Stapled-peptides tailored against initiation of translation | Descriptor: | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, Eukaryotic translation initiation factor 4 gamma 1, Eukaryotic translation initiation factor 4E | Authors: | Lama, D, Liberator, A, Frosi, Y, Nakhle, J, Tsomia, N, Bashir, T, Lane, D.P, Brown, C.J, Verma, C.S, Auvin, S, Ciesielski, F, Uhring, M. | Deposit date: | 2018-03-22 | Release date: | 2019-02-20 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Structural insights reveal a recognition feature for tailoring hydrocarbon stapled-peptides against the eukaryotic translation initiation factor 4E protein. Chem Sci, 10, 2019
|
|
5OVH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ovh by Molmil](/molmil-images/mine/5ovh) | Ras guanine nucleotide exchange factor SOS1 (Rem-cdc25) in complex with small molecule inhibitor compound 21 | Descriptor: | 1,2-ETHANEDIOL, Son of sevenless homolog 1, [2-[5-[(1~{R})-1-[(6,7-dimethoxy-2-methyl-5,8-dihydroquinazolin-4-yl)amino]ethyl]thiophen-2-yl]phenyl]methanol | Authors: | Hillig, R.C, Sautier, B, Schroeder, J, Moosmayer, D, Hilpmann, A, Stegmann, C.M, Briem, H, Boemer, U, Weiske, J, Badock, V, Petersen, K, Kahmann, J, Wegener, D, Bohnke, N, Eis, K, Graham, K, Wortmann, L, von Nussbaum, F, Bader, B. | Deposit date: | 2017-08-28 | Release date: | 2019-02-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Discovery of potent SOS1 inhibitors that block RAS activation via disruption of the RAS-SOS1 interaction. Proc. Natl. Acad. Sci. U.S.A., 116, 2019
|
|
5OOI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ooi by Molmil](/molmil-images/mine/5ooi) | STRUCTURE OF PROTEIN KINASE CK2 CATALYTIC SUBUNIT (ISOFORM CK2ALPHA') IN COMPLEX WITH THE INDENOINDOLE-TYPE INHIBITOR 4P | Descriptor: | 1,2-ETHANEDIOL, 4-(3-methylbut-2-enoxy)-5-propan-2-yl-7,8-dihydro-6~{H}-indeno[1,2-b]indole-9,10-dione, ACETATE ION, ... | Authors: | Hochscherf, J, Lindenblatt, D, Witulski, B, Birus, R, Aichele, D, Marminon, C, Bouaziz, Z, Le Borgne, M, Jose, J, Niefind, K. | Deposit date: | 2017-08-07 | Release date: | 2017-12-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.998 Å) | Cite: | Unexpected Binding Mode of a Potent Indeno[1,2-b]indole-Type Inhibitor of Protein Kinase CK2 Revealed by Complex Structures with the Catalytic Subunit CK2 alpha and Its Paralog CK2 alpha '. Pharmaceuticals (Basel), 10, 2017
|
|
5OX9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5ox9 by Molmil](/molmil-images/mine/5ox9) | Structure of the Cyan Fluorescent Protein SCFP3A at pH 4.5 | Descriptor: | CHLORIDE ION, Green fluorescent protein | Authors: | Gotthard, G, von Stetten, D, Clavel, D, Noirclerc-Savoye, M, Royant, A. | Deposit date: | 2017-09-06 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Chromophore Isomer Stabilization Is Critical to the Efficient Fluorescence of Cyan Fluorescent Proteins. Biochemistry, 56, 2017
|
|
5ZNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zni by Molmil](/molmil-images/mine/5zni) | |
7UEK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uek by Molmil](/molmil-images/mine/7uek) | |
7P62
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p62 by Molmil](/molmil-images/mine/7p62) | Complex I from E. coli, DDM-purified, Apo, Resting state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, FE2/S2 (INORGANIC) CLUSTER, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-15 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7UVQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7uvq by Molmil](/molmil-images/mine/7uvq) | Pfs230 domain 1 bound by RUPA-97 and 15C5 Fabs | Descriptor: | Fab Heavy Chain, Fab Kappa Light Chain, Gametocyte surface protein P230 | Authors: | Ivanochko, D, Julien, J.P. | Deposit date: | 2022-05-02 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (3.29 Å) | Cite: | Potent transmission-blocking monoclonal antibodies from naturally exposed individuals target a conserved epitope on Plasmodium falciparum Pfs230. Immunity, 56, 2023
|
|
7P63
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p63 by Molmil](/molmil-images/mine/7p63) | Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 6, Closed state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-15 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P61
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p61 by Molmil](/molmil-images/mine/7p61) | Complex I from E. coli, DDM-purified, with NADH, Resting state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-15 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P69
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p69 by Molmil](/molmil-images/mine/7p69) | Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 6, Resting state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, CALCIUM ION, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-15 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P64
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p64 by Molmil](/molmil-images/mine/7p64) | Complex I from E. coli, DDM/LMNG-purified, under Turnover at pH 6, Open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-15 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P7L
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7l by Molmil](/molmil-images/mine/7p7l) | Complex I from E. coli, DDM/LMNG-purified, with NADH and FMN, Open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P7C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7c by Molmil](/molmil-images/mine/7p7c) | Complex I from E. coli, DDM/LMNG-purified, Apo, Open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7P7E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7e by Molmil](/molmil-images/mine/7p7e) | Complex I from E. coli, DDM/LMNG-purified, Apo, Resting state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
5OXC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5oxc by Molmil](/molmil-images/mine/5oxc) | Structure of Cerulean Fluorescent Protein at 1.02 Angstrom resolution | Descriptor: | Green fluorescent protein | Authors: | Gotthard, G, von Stetten, D, Clavel, D, Noirclerc-Savoye, M, Royant, A. | Deposit date: | 2017-09-06 | Release date: | 2017-11-29 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.02 Å) | Cite: | Chromophore Isomer Stabilization Is Critical to the Efficient Fluorescence of Cyan Fluorescent Proteins. Biochemistry, 56, 2017
|
|
7P7J
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7j by Molmil](/molmil-images/mine/7p7j) | Complex I from E. coli, DDM/LMNG-purified, with DQ, Open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione, CALCIUM ION, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
5ZQN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zqn by Molmil](/molmil-images/mine/5zqn) | Crystal structure of Mycobacterium tuberculosis HisB in complex with a ligand | Descriptor: | (2R,3S)-2,3-dihydroxy-3-(1H-imidazol-5-yl)propyl dihydrogen phosphate, CHLORIDE ION, Imidazoleglycerol-phosphate dehydratase, ... | Authors: | Kumar, D, Pal, R.K, Biswal, B.K. | Deposit date: | 2018-04-19 | Release date: | 2018-05-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Characterization of a triazole scaffold compound as an inhibitor of Mycobacterium tuberculosis imidazoleglycerol-phosphate dehydratase. Proteins, 2021
|
|
7PBU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pbu by Molmil](/molmil-images/mine/7pbu) | RuvAB branch migration motor complexed to the Holliday junction - RuvA-HJ core [t2 dataset] | Descriptor: | Holliday junction, Holliday junction ATP-dependent DNA helicase RuvA | Authors: | Goessweiner-Mohr, N, Fahrenkamp, D, Wald, J, Marlovits, T.C. | Deposit date: | 2021-08-02 | Release date: | 2022-09-14 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration. Nature, 609, 2022
|
|
7P7M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7m by Molmil](/molmil-images/mine/7p7m) | Complex I from E. coli, DDM/LMNG-purified, inhibited by Piericidin A, Open state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7PBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pbl by Molmil](/molmil-images/mine/7pbl) | RuvAB branch migration motor complexed to the Holliday junction - RuvB AAA+ state s1 [t2 dataset] | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Holliday junction ATP-dependent DNA helicase RuvA, Holliday junction ATP-dependent DNA helicase RuvB, ... | Authors: | Fahrenkamp, D, Goessweiner-Mohr, N, Wald, J, Marlovits, T.C. | Deposit date: | 2021-08-02 | Release date: | 2022-09-14 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration. Nature, 609, 2022
|
|
7P7K
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7p7k by Molmil](/molmil-images/mine/7p7k) | Complex I from E. coli, DDM/LMNG-purified, with DQ, Resting state | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, CALCIUM ION, EICOSANE, ... | Authors: | Kravchuk, V, Kampjut, D, Sazanov, L. | Deposit date: | 2021-07-19 | Release date: | 2022-09-21 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A universal coupling mechanism of respiratory complex I. Nature, 609, 2022
|
|
7PBO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7pbo by Molmil](/molmil-images/mine/7pbo) | RuvAB branch migration motor complexed to the Holliday junction - RuvB AAA+ state s4 [t2 dataset] | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Holliday junction ATP-dependent DNA helicase RuvA, Holliday junction ATP-dependent DNA helicase RuvB, ... | Authors: | Fahrenkamp, D, Goessweiner-Mohr, N, Wald, J, Marlovits, T.C. | Deposit date: | 2021-08-02 | Release date: | 2022-09-14 | Last modified: | 2024-07-17 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Mechanism of AAA+ ATPase-mediated RuvAB-Holliday junction branch migration. Nature, 609, 2022
|
|