3QQ6
 
 | | The N-terminal DNA binding domain of SinR from Bacillus subtilis | | Descriptor: | HTH-type transcriptional regulator sinR | | Authors: | Colledge, V, Fogg, M.J, Levdikov, V.M, Dodson, E.J, Wilkinson, A.J. | | Deposit date: | 2011-02-15 | | Release date: | 2011-06-15 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structure and Organisation of SinR, the Master Regulator of Biofilm Formation in Bacillus subtilis.
J.Mol.Biol., 411, 2011
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3TGF
 | | THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA | | Descriptor: | TRANSFORMING GROWTH FACTOR-ALPHA | | Authors: | Harvey, T.S, Wilkinson, A.J, Tappin, M.J, Cooke, R.M, Campbell, I.D. | | Deposit date: | 1991-01-23 | | Release date: | 1993-04-15 | | Last modified: | 2024-11-13 | | Method: | SOLUTION NMR | | Cite: | The solution structure of human transforming growth factor alpha.
Eur.J.Biochem., 198, 1991
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1XOC
 | | The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide. | | Descriptor: | Nonapeptide VDSKNTSSW, Oligopeptide-binding protein appA, ZINC ION | | Authors: | Levdikov, V.M, Blagova, E.V, Brannigan, J.A, Wright, L, Vagin, A.A, Wilkinson, A.J. | | Deposit date: | 2004-10-06 | | Release date: | 2005-01-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | The structure of the oligopeptide-binding protein, AppA, from Bacillus subtilis in complex with a nonapeptide.
J.Mol.Biol., 345, 2005
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2W40
 | | Crystal structure of Plasmodium falciparum glycerol kinase with bound glycerol | | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, GLYCEROL KINASE, ... | | Authors: | Schnick, C, Polley, S.D, Fivelman, Q.L, Ranford-Cartwright, L, Wilkinson, S.R, Brannigan, J.A, Wilkinson, A.J, Baker, D.A. | | Deposit date: | 2008-11-18 | | Release date: | 2008-12-02 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.49 Å) | | Cite: | Structure and Non-Essential Function of Glycerol Kinase in Plasmodium Falciparum Blood Stages.
Mol.Microbiol., 71, 2009
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2PFM
 | | Crystal Structure of Adenylosuccinate Lyase (PurB) from Bacillus anthracis | | Descriptor: | Adenylosuccinate lyase, MALONATE ION | | Authors: | Levdikov, V.M, Blagova, E.V, Baumgart, M, Moroz, O.V, Wilkinson, A.J, Wilson, K.S. | | Deposit date: | 2007-04-05 | | Release date: | 2007-04-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Crystal Structure of Adenylosuccinate Lyase (PurB) from Bacillus anthracis
To be Published
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5MQH
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1LV7
 | | Crystal Structure of the AAA domain of FtsH | | Descriptor: | FtsH, SULFATE ION | | Authors: | Krzywda, S, Brzozowski, A.M, Verma, C, Karata, K, Ogura, T, Wilkinson, A.J. | | Deposit date: | 2002-05-26 | | Release date: | 2002-10-09 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The crystal structure of the AAA domain of the ATP-dependent protease FtsH of Escherichia coli at 1.5 A resolution.
Structure, 10, 2002
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2TGF
 | | THE SOLUTION STRUCTURE OF HUMAN TRANSFORMING GROWTH FACTOR ALPHA | | Descriptor: | TRANSFORMING GROWTH FACTOR-ALPHA | | Authors: | Harvey, T.S, Wilkinson, A.J, Tappin, M.J, Cooke, R.M, Campbell, I.D. | | Deposit date: | 1991-01-23 | | Release date: | 1993-04-15 | | Last modified: | 2024-10-23 | | Method: | SOLUTION NMR | | Cite: | The solution structure of human transforming growth factor alpha.
Eur.J.Biochem., 198, 1991
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4PEL
 | | S1C mutant of Penicillin G acylase from Kluyvera citrophila | | Descriptor: | CALCIUM ION, Penicillin G acylase subunit alpha, Penicillin G acylase subunit beta | | Authors: | Ramasamy, S, Chand, D, Varshney, N.K, Brannigan, J.A, Wilkinson, A.J, Suresh, C.G. | | Deposit date: | 2014-04-24 | | Release date: | 2015-07-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Penicillin G acylase
To Be Published
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5A27
 | | Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,2,4-oxadiazole inhibitor. | | Descriptor: | 5-chloranyl-N-[2-(3-methoxyphenyl)ethanimidoyl]-2-piperidin-4-yloxy-benzamide, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | | Authors: | Rackham, M.D, Yu, Z, Brannigan, J.A, Heal, W.P, Paape, D, Barker, K.V, Wilkinson, A.J, Smith, D.F, Tate, E.W, Leatherbarrow, R.J. | | Deposit date: | 2015-05-15 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.37 Å) | | Cite: | Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
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5AEO
 | | Virulence-associated protein VapG from the intracellular pathogen Rhodococcus equi | | Descriptor: | POTASSIUM ION, R. EQUI VAPG PROTEIN | | Authors: | Okoko, T, Blagova, E.V, Whittingham, J.L, Dover, L.G, Wilkinson, A.J. | | Deposit date: | 2015-01-07 | | Release date: | 2015-03-25 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Structural Characterisation of the Virulence-Associated Protein Vapg from the Horse Pathogen Rhodococcus Equi.
Vet.Microbiol., 179, 2015
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5A28
 | | Leishmania major N-myristoyltransferase in complex with a chlorophenyl 1,3,4-oxadiazole inhibitor. | | Descriptor: | 4-(4-chloro-2-{5-[(trimethyl-1H-pyrazol-4-yl)methyl]-1,3,4-oxadiazol-2-yl}phenoxy)piperidine, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | | Authors: | Rackham, M.D, Yu, Z, Brannigan, J.A, Heal, W.P, Paape, D, Barker, K.V, Wilkinson, A.J, Smith, D.F, Tate, E.W, Leatherbarrow, R.J. | | Deposit date: | 2015-05-15 | | Release date: | 2016-03-23 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Discovery of High Affinity Inhibitors of Leishmania Donovani N-Myristoyltransferase.
Medchemcomm, 6, 2015
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4TPS
 | | Sporulation Inhibitor of DNA Replication, SirA, in complex with Domain I of DnaA | | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, Chromosomal replication initiator protein DnaA, ... | | Authors: | Jameson, K.H, Turkenburg, J.P, Fogg, M.J, Grahl, A, Wilkinson, A.J. | | Deposit date: | 2014-06-09 | | Release date: | 2014-07-30 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Structure and interactions of the Bacillus subtilis sporulation inhibitor of DNA replication, SirA, with domain I of DnaA.
Mol.Microbiol., 93, 2014
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4PEM
 | | Crystal Structure of S1G mutant of Penicillin G Acylase from Kluyvera citrophila | | Descriptor: | CALCIUM ION, Penicillin G acylase Alpha, Penicillin G acylase Beta | | Authors: | Ramasamy, S, Varshney, N.K, Brannigan, J.A, Wilkinson, A.J, Suresh, C.G. | | Deposit date: | 2014-04-24 | | Release date: | 2015-07-22 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Crystal Structure of S1G mutant of Penicillin G Acylase from Kluyvera citrophilla
To be Published
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6T9M
 | | Crystal structure of the Chitinase Domain of the Spore Coat Protein CotE from Clostridium difficile | | Descriptor: | DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, Peptide in active site, ... | | Authors: | Whittingham, J.L, Dodson, E.J, Wilkinson, A.J. | | Deposit date: | 2019-10-28 | | Release date: | 2020-07-22 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | Crystal structures of the GH18 domain of the bifunctional peroxiredoxin-chitinase CotE from Clostridium difficile.
Acta Crystallogr.,Sect.F, 76, 2020
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2D30
 | | Crystal Structure of Cytidine Deaminase Cdd-2 (BA4525) from Bacillus Anthracis at 2.40A Resolution | | Descriptor: | ZINC ION, cytidine deaminase | | Authors: | Levdikov, V.M, Blagova, E.V, Fogg, M.J, Brannigan, J.A, Moroz, O.V, Wilkinson, A.J, Wilson, K.S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2005-09-21 | | Release date: | 2006-09-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal Structure of Cytidine Deaminase Cdd-2 (BA4525) from Bacillus Anthracis at 2.40A Resolution
To be Published
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4ACI
 | | Structure of the C. glutamicum AcnR Crystal Form II | | Descriptor: | CITRIC ACID, GLYCEROL, HTH-TYPE TRANSCRIPTIONAL REPRESSOR ACNR, ... | | Authors: | Garcia-Nafria, J, Baumgart, M, Turkenburg, J.P, Wilkinson, A.J, Bott, M, Wilson, K.S. | | Deposit date: | 2011-12-15 | | Release date: | 2012-12-26 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal and Solution Studies Reveal that the Transcriptional Regulator Acnr of Corynebacterium Glutamicum is Regulated by Citrate:Mg2+ Binding to a Non-Canonical Pocket.
J.Biol.Chem., 288, 2013
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4AF5
 | | Structure of the C. glutamicum AcnR Crystal Form I | | Descriptor: | CITRIC ACID, HTH-TYPE TRANSCRIPTIONAL REPRESSOR ACNR COMPND 2, MAGNESIUM ION | | Authors: | Garcia-Nafria, J, Baumgart, M, Turkenburg, J.P, Wilkinson, A.J, Bott, M, Wilson, K.S. | | Deposit date: | 2012-01-17 | | Release date: | 2013-01-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal and Solution Studies Reveal that the Transcriptional Regulator Acnr of Corynebacterium Glutamicum is Regulated by Citrate:Mg2+ Binding to a Non-Canonical Pocket.
J.Biol.Chem., 288, 2013
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2CEY
 | | Apo Structure of SiaP | | Descriptor: | PROTEIN HI0146, ZINC ION | | Authors: | Muller, A, Severi, E, Mulligan, C, Watts, A.G, Kelly, D.J, Wilson, K.S, Wilkinson, A.J, Thomas, G.H. | | Deposit date: | 2006-02-11 | | Release date: | 2006-05-15 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Conservation of Structure and Mechanism in Primary and Secondary Transporters Exemplified by Siap, a Sialic Acid Binding Virulence Factor from Haemophilus Influenzae
J.Biol.Chem., 281, 2006
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9FDD
 | | The crystal structure of full length tetramer CysB from Klebsiella aerogenes in complex with N-acetylserine | | Descriptor: | HTH-type transcriptional regulator CysB, N-ACETYL-SERINE | | Authors: | Verschueren, K.H.G, Dodson, E.J, Wilkinson, A.J. | | Deposit date: | 2024-05-16 | | Release date: | 2024-07-03 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
Eur.Biophys.J., 53, 2024
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9F14
 | | The crystal structure of full length tetramer CysB from Klebsiella aerogenes in complex with N-acetylserine | | Descriptor: | HTH-type transcriptional regulator CysB, N-ACETYL-SERINE | | Authors: | Verschueren, K.H.G, Dodson, E.J, Wilkinson, A.J. | | Deposit date: | 2024-04-18 | | Release date: | 2024-07-24 | | Last modified: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | The Structure of the LysR-type Transcriptional Regulator, CysB, Bound to the Inducer, N-acetylserine.
Eur.Biophys.J., 53, 2024
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2FYI
 | | Crystal Structure of the Cofactor-Binding Domain of the Cbl Transcriptional Regulator | | Descriptor: | HTH-type transcriptional regulator cbl | | Authors: | Stec, E, Neumann, P, Wilkinson, A.J, Brzozowski, A.M, Bujacz, G.D. | | Deposit date: | 2006-02-08 | | Release date: | 2006-02-21 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural Basis of the Sulphate Starvation Response in E. coli: Crystal Structure and Mutational Analysis of the Cofactor-binding Domain of the Cbl Transcriptional Regulator.
J.Mol.Biol., 364, 2006
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1DZ3
 | | DOMAIN-SWAPPING IN THE SPORULATION RESPONSE REGULATOR SPO0A | | Descriptor: | SULFATE ION, Stage 0 sporulation protein A | | Authors: | Lewis, R.J, Brannigan, J.A, Muchova, K, Leonard, G, Barak, I, Wilkinson, A.J. | | Deposit date: | 2000-02-15 | | Release date: | 2000-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Domain swapping in the sporulation response regulator Spo0A.
J. Mol. Biol., 297, 2000
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4CGL
 | | Leishmania major N-myristoyltransferase in complex with an aminoacylpyrrolidine inhibitor | | Descriptor: | (3R)-3-azanyl-4-(4-chlorophenyl)-1-[(3S,4R)-3-(4-chlorophenyl)-4-(hydroxymethyl)pyrrolidin-1-yl]butan-1-one, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, MAGNESIUM ION, ... | | Authors: | Brannigan, J.A, Roberts, S.M, Bell, A.S, Hutton, J.A, Smith, D.F, Tate, E.W, Leatherbarrow, R.J, Wilkinson, A.J. | | Deposit date: | 2013-11-25 | | Release date: | 2014-07-09 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Diverse Modes of Binding in Structures of Leishmania Major N-Myristoyltransferase with Selective Inhibitors
Iucrj, 1, 2014
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1QMP
 | | Phosphorylated aspartate in the crystal structure of the sporulation response regulator, Spo0A | | Descriptor: | CALCIUM ION, Stage 0 sporulation protein A | | Authors: | Lewis, R.J, Brannigan, J.A, Muchova, K, Barak, I, Wilkinson, A.J. | | Deposit date: | 1999-10-04 | | Release date: | 1999-11-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Phosphorylated aspartate in the structure of a response regulator protein.
J. Mol. Biol., 294, 1999
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