5M2W
 
 | | Structure of nanobody nb18 raised against TssK from E. coli T6SS | | Descriptor: | Llama nanobody nb8 against TssK from T6SS, SULFATE ION | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A. | | Deposit date: | 2016-10-13 | | Release date: | 2017-06-28 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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1KXQ
 | | Camelid VHH Domain in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | CALCIUM ION, CHLORIDE ION, alpha-amylase, ... | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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5M2I
 | | Structure of human Tumor Necrosis Factor (TNF) in complex with the Llama VHH1 | | Descriptor: | Tumor necrosis factor, VHH1 | | Authors: | Cambillau, C, Spinelli, S, Desmyter, A, de Haard, H. | | Deposit date: | 2016-10-13 | | Release date: | 2017-08-30 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Bivalent Llama Single-Domain Antibody Fragments against Tumor Necrosis Factor Have Picomolar Potencies due to Intramolecular Interactions.
Front Immunol, 8, 2017
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1OW4
 | | Crystal structure of a pheromone binding protein from the cockroach Leucophaea maderae in complex with the fluorescent reporter ANS (1-anilinonaphtalene-8-sulfonic acid), | | Descriptor: | 8-ANILINO-1-NAPHTHALENE SULFONATE, GLYCEROL, pheromone binding protein | | Authors: | Lartigue, A, Gruez, A, Spinelli, S, Riviere, S, Brossut, R, Tegoni, M, Cambillau, C. | | Deposit date: | 2003-03-28 | | Release date: | 2003-08-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | THE CRYSTAL STRUCTURE OF A COCKROACH PHEROMONE-BINDING PROTEIN SUGGESTS A NEW LIGAND BINDING AND RELEASE MECHANISM
J.Biol.Chem., 278, 2003
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5M2Y
 | | Structure of TssK C-terminal domain from E. coli T6SS | | Descriptor: | TssK C | | Authors: | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A, Legrand, P. | | Deposit date: | 2016-10-13 | | Release date: | 2017-06-28 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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4JEI
 | | Nonglycosylated Yarrowia lipolytica LIP2 lipase | | Descriptor: | Lipase 2 | | Authors: | Aloulou, A, Benarouche, A, Puccinelli, D, Spinelli, S, Cavalier, J.-F, Cambillau, C, Carriere, F. | | Deposit date: | 2013-02-27 | | Release date: | 2013-03-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Biochemical and structural characterization of non-glycosylated Yarrowia lipolytica LIP2 lipase
To be published
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1KXT
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | ALPHA-AMYLASE, PANCREATIC, CALCIUM ION, ... | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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1QFW
 | | TERNARY COMPLEX OF HUMAN CHORIONIC GONADOTROPIN WITH FV ANTI ALPHA SUBUNIT AND FV ANTI BETA SUBUNIT | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ANTIBODY (ANTI ALPHA SUBUNIT) (HEAVY CHAIN), ANTIBODY (ANTI ALPHA SUBUNIT) (LIGHT CHAIN), ... | | Authors: | Tegoni, M, Spinelli, S, Cambillau, C. | | Deposit date: | 1999-04-15 | | Release date: | 2000-04-26 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structure of a ternary complex between human chorionic gonadotropin (hCG) and two Fv fragments specific for the alpha and beta-subunits.
J.Mol.Biol., 289, 1999
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1KXV
 | | Camelid VHH Domains in Complex with Porcine Pancreatic alpha-Amylase | | Descriptor: | ALPHA-AMYLASE, PANCREATIC, CAMELID VHH DOMAIN CAB10 | | Authors: | Desmyter, A, Spinelli, S, Payan, F, Lauwereys, M, Wyns, L, Muyldermans, S, Cambillau, C. | | Deposit date: | 2002-02-01 | | Release date: | 2002-06-19 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Three camelid VHH domains in complex with porcine pancreatic alpha-amylase. Inhibition and versatility of binding topology.
J.Biol.Chem., 277, 2002
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4PS2
 | | Structure of the C-terminal fragment (87-165) of E.coli EAEC TssB molecule | | Descriptor: | CHLORIDE ION, Putative type VI secretion protein, ZINC ION | | Authors: | Douzi, B, Logger, L, Spinelli, S, Blangy, S, Cambillau, C, Cascales, E. | | Deposit date: | 2014-03-06 | | Release date: | 2015-03-11 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Mapping the tube-sheath interface within the Type VI secretion system tail
To be Published
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1U0Q
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1I3G
 | | CRYSTAL STRUCTURE OF AN AMPICILLIN SINGLE CHAIN FV, FORM 1, FREE | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, ANTIBODY FV FRAGMENT | | Authors: | Jung, S, Spinelli, S, Schimmele, B, Honegger, A, Pugliese, L, Cambillau, C, Pluckthun, A. | | Deposit date: | 2001-02-15 | | Release date: | 2001-10-17 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | Selection, characterization and x-ray structure of anti-ampicillin single-chain Fv fragments from phage-displayed murine antibody libraries.
J.Mol.Biol., 309, 2001
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1SJX
 | | Three-Dimensional Structure of a Llama VHH Domain OE7 binding the cell wall protein Malf1 | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, immunoglobulin VH domain | | Authors: | Dolk, E, van der Vaart, M, Hulsik, D.L, Vriend, G, de Haard, H, Spinelli, S, Cambillau, C, Frenken, L, Verrips, T. | | Deposit date: | 2004-03-04 | | Release date: | 2005-03-15 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Isolation of llama antibody fragments for prevention of dandruff by phage display in shampoo.
Appl.Environ.Microbiol., 71, 2005
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4Y7M
 | | T6SS protein TssM C-terminal domain (835-1129) from EAEC | | Descriptor: | Hi113 protein, SULFATE ION, Type VI secretion protein IcmF | | Authors: | Nguyen, V.S, Spinelli, S, Durand, E, Roussel, A, Cambillau, C. | | Deposit date: | 2015-02-15 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | Biogenesis and structure of a type VI secretion membrane core complex.
Nature, 523, 2015
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4YO3
 | | Enteroaggregative Escherichia Coli TssA N-terminal fragment | | Descriptor: | TssA | | Authors: | Durand, E, Zoued, A, Spinelli, S, Douzi, B, Brunet, Y.R, Bebeacua, C, Legrand, P, Journet, L, Mignot, T, Cambillau, C, Cascales, E. | | Deposit date: | 2015-03-11 | | Release date: | 2016-02-17 | | Last modified: | 2017-08-30 | | Method: | X-RAY DIFFRACTION (3.37 Å) | | Cite: | Priming and polymerization of a bacterial contractile tail structure.
Nature, 531, 2016
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4Y7L
 | | T6SS protein TssM C-terminal domain (869-1107) from EAEC | | Descriptor: | GLYCEROL, Type VI secretion protein IcmF, ZINC ION | | Authors: | Nguyen, V.S, Spinelli, S, Durand, E, Roussel, A, Cambillau, C. | | Deposit date: | 2015-02-15 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.51 Å) | | Cite: | Biogenesis and structure of a type VI secretion membrane core complex.
Nature, 523, 2015
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4Y7O
 | | T6SS protein TssM C-terminal domain (869-1107) from EAEC | | Descriptor: | Type VI secretion protein IcmF, Type VI secretion system protein VasD, ZINC ION | | Authors: | Nguyen, V.S, Spinelli, S, Durand, E, Roussel, A, Cambillau, C. | | Deposit date: | 2015-02-15 | | Release date: | 2015-08-05 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.24 Å) | | Cite: | Biogenesis and structure of a type VI secretion membrane core complex.
Nature, 523, 2015
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4YO5
 | | EAEC T6SS TssA-Cterminus | | Descriptor: | TssA | | Authors: | Durand, E, Zoued, A, Spinelli, S, Douzi, B, Brunet, Y.R, Bebeacua, C, Legrand, P, Journet, L, Mignot, T, Cambillau, C, Cascales, E. | | Deposit date: | 2015-03-11 | | Release date: | 2016-02-17 | | Last modified: | 2017-06-14 | | Method: | X-RAY DIFFRACTION (3.35 Å) | | Cite: | Priming and polymerization of a bacterial contractile tail structure.
Nature, 531, 2016
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4ZS7
 | | Structural mimicry of receptor interaction by antagonistic IL-6 antibodies | | Descriptor: | Interleukin-6, Llama Fab fragment 68F2 heavy chain, Llama Fab fragment 68F2 light chain | | Authors: | Blanchetot, C, De Jonge, N, Desmyter, A, Ongenae, N, Hofman, E, Klarenbeek, A, Sadi, A, Hultberg, A, Kretz-Rommel, A, Spinelli, S, Loris, R, Cambillau, C, de Haard, H. | | Deposit date: | 2015-05-13 | | Release date: | 2016-05-04 | | Last modified: | 2016-07-06 | | Method: | X-RAY DIFFRACTION (2.93 Å) | | Cite: | Structural Mimicry of Receptor Interaction by Antagonistic Interleukin-6 (IL-6) Antibodies.
J.Biol.Chem., 291, 2016
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1NZJ
 | | Crystal Structure and Activity Studies of Escherichia Coli Yadb ORF | | Descriptor: | Hypothetical protein yadB, ZINC ION | | Authors: | Campanacci, V, Kern, D.Y, Becker, H.D, Spinelli, S, Valencia, C, Vincentelli, R, Pagot, F, Bignon, C, Giege, R, Cambillau, C. | | Deposit date: | 2003-02-18 | | Release date: | 2004-04-13 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | The Escherichia coli YadB gene product reveals a novel aminoacyl-tRNA synthetase like activity.
J.Mol.Biol., 337, 2004
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4GRW
 | | Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs) | | Descriptor: | Interleukin-12 subunit beta, Interleukin-23 subunit alpha, Nanobody 124C4, ... | | Authors: | Desmyter, A, Spinelli, S, Button, C, Saunders, M, de Haard, H, Rommelaere, H, Union, A, Cambillau, C. | | Deposit date: | 2012-08-27 | | Release date: | 2014-02-19 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2.55 Å) | | Cite: | Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex.
Front Immunol, 8, 2017
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4HH5
 | | N-terminal domain (1-163) of ClpV1 ATPase from E.coli EAEC Sci1 T6SS. | | Descriptor: | BROMIDE ION, Putative type VI secretion protein | | Authors: | Douzi, B, Spinelli, S, Legrand, P, Lensi, V, Brunet, Y.R, Cascales, E, Cambillau, C. | | Deposit date: | 2012-10-09 | | Release date: | 2013-11-20 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Role and specificity of ClpV ATPases in T6SS secretion.
To be Published
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4HH6
 | | Peptide from EAEC T6SS Sci1 SciI protein | | Descriptor: | Peptide from EAEC T6SS Sci1 SciI protein, Putative type VI secretion protein | | Authors: | Douzi, B, Spinelli, S, Legrand, P, Lensi, V, Brunet, Y.R, Cascales, E, Cambillau, C. | | Deposit date: | 2012-10-09 | | Release date: | 2013-11-20 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Role and specificity of ClpV ATPases in T6SS secretion.
To be Published
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4GQK
 | | Structure of Native VgrG1-ACD with ADP (no cations) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, SULFATE ION, VgrG protein | | Authors: | Nguyen, V.S, Spinelli, S, Derrez, E, Durand, E, Cambillau, C. | | Deposit date: | 2012-08-23 | | Release date: | 2013-09-25 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.36 Å) | | Cite: | Structure of Native VgrG1-ACD with ADP (no cations)
To be Published
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3DA0
 | | Crystal structure of a cleaved form of a chimeric receptor binding protein from Lactococcal phages subspecies TP901-1 and p2 | | Descriptor: | Cleaved chimeric receptor binding protein from bacteriophages TP901-1 and p2 | | Authors: | Siponen, M.I, Blangy, S, Spinelli, S, Vera, L, Cambillau, C, Campanacci, V. | | Deposit date: | 2008-05-28 | | Release date: | 2009-06-09 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of a chimeric receptor binding protein constructed from two lactococcal phages.
J.Bacteriol., 191, 2009
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