7WNI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wni by Molmil](/molmil-images/mine/7wni) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13158 | Descriptor: | 1,2-ETHANEDIOL, 7-[2-[2,4-bis(fluoranyl)phenoxy]-5-(2-oxidanylpropan-2-yl)phenyl]-2-[4-(2-hydroxyethyloxy)-3,5-dimethyl-phenyl]-5-methyl-furo[3,2-c]pyridin-4-one, DI(HYDROXYETHYL)ETHER, ... | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-18 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.12 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
7WMU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wmu by Molmil](/molmil-images/mine/7wmu) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13146 | Descriptor: | 1,2-ETHANEDIOL, Isoform 4 of Bromodomain-containing protein 2, ~{N}-[4-[2,4-bis(fluoranyl)phenoxy]-3-[2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-5-methyl-4-oxidanylidene-furo[3,2-c]pyridin-7-yl]phenyl]ethanesulfonamide | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-17 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
7WN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wn5 by Molmil](/molmil-images/mine/7wn5) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13142 | Descriptor: | 1,2-ETHANEDIOL, Isoform 4 of Bromodomain-containing protein 2, POTASSIUM ION, ... | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-17 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
7WLN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wln by Molmil](/molmil-images/mine/7wln) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13153 | Descriptor: | 2-(2-cyclopentyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one, DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, ... | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-13 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
7WNA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wna by Molmil](/molmil-images/mine/7wna) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13120 | Descriptor: | 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Isoform 4 of Bromodomain-containing protein 2, ... | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-17 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
7WMQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wmq by Molmil](/molmil-images/mine/7wmq) | Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor Y13157 | Descriptor: | 2-(2-cyclobutyl-1~{H}-imidazol-5-yl)-7-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-5-methyl-furo[3,2-c]pyridin-4-one, FORMIC ACID, GLYCEROL, ... | Authors: | Li, J, Zhang, C, Xu, H, Zhuang, X, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-01-16 | Release date: | 2022-08-10 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.37 Å) | Cite: | Structure-Based Discovery and Optimization of Furo[3,2- c ]pyridin-4(5 H )-one Derivatives as Potent and Second Bromodomain (BD2)-Selective Bromo and Extra Terminal Domain (BET) Inhibitors. J.Med.Chem., 65, 2022
|
|
1COY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1coy by Molmil](/molmil-images/mine/1coy) | CRYSTAL STRUCTURE OF CHOLESTEROL OXIDASE COMPLEXED WITH A STEROID SUBSTRATE. IMPLICATIONS FOR FAD DEPENDENT ALCOHOL OXIDASES | Descriptor: | 3-BETA-HYDROXY-5-ANDROSTEN-17-ONE, CHOLESTEROL OXIDASE, FLAVIN-ADENINE DINUCLEOTIDE | Authors: | Li, J, Vrielink, A, Brick, P, Blow, D.M. | Deposit date: | 1993-06-14 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of cholesterol oxidase complexed with a steroid substrate: implications for flavin adenine dinucleotide dependent alcohol oxidases. Biochemistry, 32, 1993
|
|
1FBL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fbl by Molmil](/molmil-images/mine/1fbl) | STRUCTURE OF FULL-LENGTH PORCINE SYNOVIAL COLLAGENASE (MMP1) REVEALS A C-TERMINAL DOMAIN CONTAINING A CALCIUM-LINKED, FOUR-BLADED BETA-PROPELLER | Descriptor: | CALCIUM ION, FIBROBLAST (INTERSTITIAL) COLLAGENASE (MMP-1), N-[3-(N'-HYDROXYCARBOXAMIDO)-2-(2-METHYLPROPYL)-PROPANOYL]-O-TYROSINE-N-METHYLAMIDE, ... | Authors: | Li, J, Brick, P, Blow, D.M. | Deposit date: | 1995-04-24 | Release date: | 1996-01-29 | Last modified: | 2012-02-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller. Structure, 3, 1995
|
|
2ELB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2elb by Molmil](/molmil-images/mine/2elb) | Crystal Structure of the BAR-PH domain of human APPL1 | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | Deposit date: | 2007-03-27 | Release date: | 2007-05-29 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
|
|
2B26
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2b26 by Molmil](/molmil-images/mine/2b26) | The crystal structure of the protein complex of yeast Hsp40 Sis1 and Hsp70 Ssa1 | Descriptor: | Heat shock 70 kDa protein cognate 2, SIS1 protein | Authors: | Li, J, Wu, Y, Qian, X, Sha, B. | Deposit date: | 2005-09-16 | Release date: | 2006-09-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Crystal structure of yeast Sis1 peptide-binding fragment and Hsp70 Ssa1 C-terminal complex. Biochem.J., 398, 2006
|
|
1GXC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1gxc by Molmil](/molmil-images/mine/1gxc) | FHA domain from human Chk2 kinase in complex with a synthetic phosphopeptide | Descriptor: | SERINE/THREONINE-PROTEIN KINASE CHK2, SYNTHETIC PHOSPHOPEPTIDE | Authors: | Li, J, Williams, B.L, Haire, L.F, Goldberg, M, Wilker, E, Durocher, D, Yaffe, M.B, Jackson, S.P, Smerdon, S.J. | Deposit date: | 2002-04-02 | Release date: | 2002-06-13 | Last modified: | 2016-12-21 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural and Functional Versatility of the Fha Domain in DNA-Damage Signaling by the Tumor Suppressor Kinase Chk2 Mol.Cell, 9, 2002
|
|
2ELA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2ela by Molmil](/molmil-images/mine/2ela) | Crystal Structure of the PTB domain of human APPL1 | Descriptor: | Adapter protein containing PH domain, PTB domain and leucine zipper motif 1 | Authors: | Li, J, Mao, X, Dong, L.Q, Liu, F, Tong, L. | Deposit date: | 2007-03-27 | Release date: | 2007-05-29 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal Structures of the BAR-PH and PTB Domains of Human APPL1 Structure, 15, 2007
|
|
4JNA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4jna by Molmil](/molmil-images/mine/4jna) | Crystal structure of the DepH complex with dimethyl-FK228 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ... | Authors: | Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E. | Deposit date: | 2013-03-14 | Release date: | 2014-03-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis. Sci Rep, 4, 2014
|
|
1NLT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nlt by Molmil](/molmil-images/mine/1nlt) | The crystal structure of Hsp40 Ydj1 | Descriptor: | Mitochondrial protein import protein MAS5, Seven residue peptide, ZINC ION | Authors: | Li, J, Sha, B. | Deposit date: | 2003-01-07 | Release date: | 2004-01-13 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The crystal structure of the yeast Hsp40 Ydj1 complexed with its peptide substrate. Structure, 11, 2003
|
|
5F3X
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f3x by Molmil](/molmil-images/mine/5f3x) | Crystal structure of Harmonin NPDZ1 in complex with ANKS4B SAM-PBM | Descriptor: | Ankyrin repeat and SAM domain-containing protein 4B, CHLORIDE ION, Harmonin | Authors: | Li, J, He, Y, Lu, Q, Zhang, M. | Deposit date: | 2015-12-03 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.649 Å) | Cite: | Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell, 36, 2016
|
|
5F3Y
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5f3y by Molmil](/molmil-images/mine/5f3y) | Crystal Structure of Myo7b N-MyTH4-FERM-SH3 in complex with Anks4b CEN | Descriptor: | Ankyrin repeat and SAM domain-containing protein 4B, Unconventional myosin-VIIb | Authors: | Li, J, He, Y, Lu, Q, Zhang, M. | Deposit date: | 2015-12-03 | Release date: | 2016-03-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (3.409 Å) | Cite: | Mechanistic Basis of Organization of the Harmonin/USH1C-Mediated Brush Border Microvilli Tip-Link Complex Dev.Cell, 36, 2016
|
|
2JQW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2jqw by Molmil](/molmil-images/mine/2jqw) | |
7WNT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wnt by Molmil](/molmil-images/mine/7wnt) | RNase J from Mycobacterium tuberculosis | Descriptor: | Ribonuclease J, ZINC ION | Authors: | Li, J, Bao, L, Hu, J, Zhan, B, Li, Z. | Deposit date: | 2022-01-19 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.44 Å) | Cite: | Structural ans functional study of RNase J from Mycobacterium tuberculosis To Be Published
|
|
7WNU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wnu by Molmil](/molmil-images/mine/7wnu) | Mycobacterium tuberculosis Rnase J complex with 7nt RNA | Descriptor: | RNA (5'-R(P*AP*AP*AP*AP*AP*AP*A)-3'), Ribonuclease J, ZINC ION | Authors: | Li, J, Hu, J, Bao, L, Zhan, B, Li, Z. | Deposit date: | 2022-01-19 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural ans functional study of RNase J from Mycobacterium tuberculosis To Be Published
|
|
8I23
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i23 by Molmil](/molmil-images/mine/8i23) | Clostridium thermocellum RNA polymerase transcription open complex with SigI1 and its promoter | Descriptor: | DNA (80-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Li, J, Zhang, H, Li, D, Feng, Y, Zhu, P. | Deposit date: | 2023-01-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.03 Å) | Cite: | Structure of the transcription open complex of distinct sigma I factors. Nat Commun, 14, 2023
|
|
8I24
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8i24 by Molmil](/molmil-images/mine/8i24) | Clostridium thermocellum RNA polymerase transcription open complex with SigI6 and its promoter | Descriptor: | DNA (80-mer), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | Authors: | Li, J, Zhang, H, Li, D, Feng, Y, Zhu, P. | Deposit date: | 2023-01-13 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | ELECTRON MICROSCOPY (3.36 Å) | Cite: | Structure of the transcription open complex of distinct sigma I factors. Nat Commun, 14, 2023
|
|
5X3V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5x3v by Molmil](/molmil-images/mine/5x3v) | Structure of human SHMT2 protein mutant | Descriptor: | SULFATE ION, Serine hydroxymethyltransferase, mitochondrial | Authors: | Li, J, Sheng, J. | Deposit date: | 2017-02-09 | Release date: | 2018-02-14 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Structure of human SHMT2 protein mutant To Be Published
|
|
6LBM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lbm by Molmil](/molmil-images/mine/6lbm) | |
6LBI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6lbi by Molmil](/molmil-images/mine/6lbi) | |
6M3Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6m3q by Molmil](/molmil-images/mine/6m3q) | Crystal structure of AnkB/beta4-spectrin complex | Descriptor: | Ankyrin-2, Spectrin beta chain | Authors: | Li, J, Chen, K, Zhu, R, Zhang, M. | Deposit date: | 2020-03-04 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.436 Å) | Cite: | Structural Basis Underlying Strong Interactions between Ankyrins and Spectrins. J.Mol.Biol., 432, 2020
|
|