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4GEX
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BU of 4gex by Molmil
Structure of a stabilised ceSAS-6 dimer, second crystal form
Descriptor: SULFATE ION, Spindle assembly abnormal protein 6
Authors:Erat, M.C, Vakonakis, I.
Deposit date:2012-08-02
Release date:2013-06-19
Last modified:2013-07-24
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Caenorhabditis elegans centriolar protein SAS-6 forms a spiral that is consistent with imparting a ninefold symmetry.
Proc.Natl.Acad.Sci.USA, 110, 2013
4TS6
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BU of 4ts6 by Molmil
Crystal structure of the RIM C2A domain from Drosophila.
Descriptor: GLYCEROL, Rab3 interacting molecule variant 2
Authors:Hatzopoulos, G.N, Shiroma, J, Vakonakis, I.
Deposit date:2014-06-18
Release date:2015-07-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Crystal structure of the RIM C2A domain from Drosophila.
To Be Published
1R8J
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BU of 1r8j by Molmil
Crystal Structure of Circadian Clock Protein KaiA from Synechococcus elongatus
Descriptor: KaiA
Authors:Ye, S, Vakonakis, I, Sacchettini, J.C, LiWang, A.C.
Deposit date:2003-10-26
Release date:2004-06-01
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:Crystal structure of circadian clock protein KaiA from Synechococcus elongatus
J.Biol.Chem., 279, 2004
6YRL
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BU of 6yrl by Molmil
Structure of the Chlamydomonas reinhardtii SAS-6 coiled-coil domain, C2 crystal form
Descriptor: Centriole protein
Authors:Kantsadi, A.L, Vakonakis, I.
Deposit date:2020-04-20
Release date:2021-05-12
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel.
Structure, 2022
6YRN
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BU of 6yrn by Molmil
Structure of the Chlamydomonas reinhardtii SAS-6 coiled-coil domain, P2 crystal form
Descriptor: Centriole protein, TETRAETHYLENE GLYCOL
Authors:Kantsadi, A.L, Vakonakis, I.
Deposit date:2020-04-20
Release date:2021-05-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (2.43 Å)
Cite:Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel.
Structure, 2022
6YS4
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BU of 6ys4 by Molmil
Structure of the Homo sapiens SAS-6 coiled-coil domain
Descriptor: GLYCINE, Spindle assembly abnormal protein 6 homolog, TETRAETHYLENE GLYCOL
Authors:Kantsadi, A.L, Vakonakis, I.
Deposit date:2020-04-21
Release date:2021-05-12
Last modified:2022-03-16
Method:X-RAY DIFFRACTION (2.11 Å)
Cite:Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel.
Structure, 2022
6ZHI
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BU of 6zhi by Molmil
Structure of the Plasmodium falciparum Hsp70-x substrate binding domain in complex with hydrophobic peptide
Descriptor: ASN-ARG-LEU-LEU-LEU-THR-GLY, Heat shock protein 70
Authors:Schmidt, J, Vakonakis, I.
Deposit date:2020-06-23
Release date:2020-09-09
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (3.25 Å)
Cite:Structure of the PfHsp70-x SBD
Acta Crystallographica Section F
6Z26
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BU of 6z26 by Molmil
Structure of the Danio rerio SAS-6 coiled-coil domain
Descriptor: Spindle assembly abnormal protein 6 homolog
Authors:Kantsadi, A.L, Vakonakis, I.
Deposit date:2020-05-15
Release date:2021-05-26
Last modified:2022-05-18
Method:X-RAY DIFFRACTION (2.32 Å)
Cite:Structures of SAS-6 coiled coil hold implications for the polarity of the centriolar cartwheel.
Structure, 30, 2022
6Z4A
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BU of 6z4a by Molmil
Structure of the human SAS-6 N-terminal domain, F131E mutant
Descriptor: GLYCEROL, Spindle assembly abnormal protein 6 homolog
Authors:Busch, J.M.C, Vakonakis, I.
Deposit date:2020-05-25
Release date:2020-09-09
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerization.
J.Biol.Chem., 295, 2020
4TPZ
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BU of 4tpz by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p F145W (NN2)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-10
Release date:2015-06-24
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
2V76
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BU of 2v76 by Molmil
Crystal structure of the human dok1 PTB domain
Descriptor: 1,2-ETHANEDIOL, DOCKING PROTEIN 1, GLYCEROL, ...
Authors:Oxley, C.L, Anthis, N.J, Lowe, E.D, Campbell, I.D, Wegener, K.L.
Deposit date:2007-07-26
Release date:2008-01-08
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:An Integrin Phosphorylation Switch: The Effect of {Beta}3 Integrin Tail Phosphorylation on Dok1 and Talin Binding.
J.Biol.Chem., 283, 2008
4TO7
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BU of 4to7 by Molmil
N-Terminal domain of C. Reinhardtii SAS-6 homolog bld12p Q93E F145W K146R (NN24)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-05
Release date:2015-06-17
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.252 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TQ7
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BU of 4tq7 by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p Q93E (NN10)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-10
Release date:2015-06-24
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.643 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTZ
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BU of 4ttz by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p variant G94E F145W Q147K (NN26)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTW
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BU of 4ttw by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p K105C F145C (NN18)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.2 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4TTX
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BU of 4ttx by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p variant G94C K146C (NN19)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-06-23
Release date:2015-07-01
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4U2J
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BU of 4u2j by Molmil
N-terminal domain of C. Reinhardtii SAS-6 homolog bld12p variant Q93E F145W (NN27)
Descriptor: Centriole protein
Authors:Hilbert, M, Kraatz, S.H.W.
Deposit date:2014-07-17
Release date:2015-07-29
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:SAS-6 engineering reveals interdependence between cartwheel and microtubules in determining centriole architecture.
Nat.Cell Biol., 18, 2016
4HKC
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BU of 4hkc by Molmil
14-3-3-zeta in complex with S1011 phosphorylated integrin alpha-4 peptide
Descriptor: 14-3-3 protein zeta/delta, GLYCEROL, alpha-4 integrin derived phosphorylated peptide
Authors:Bonet, R, Campbell, I.D.
Deposit date:2012-10-15
Release date:2013-06-26
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of 14-3-3-zeta Interactions with integrin tails
J.Mol.Biol., 425, 2013
7GMK
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BU of 7gmk by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with PET-UNK-d899bab6-1 (Mpro-P2201)
Descriptor: 2-(3-chlorophenyl)-N-[6-(dimethylamino)isoquinolin-4-yl]acetamide, 3C-like proteinase, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.845 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GMW
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BU of 7gmw by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-e119ab4f-1 (Mpro-P2224)
Descriptor: (4S)-6-chloro-N-(7-fluoroisoquinolin-4-yl)-2-[2-(methylamino)-2-oxoethyl]-1-oxo-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.826 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GNJ
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BU of 7gnj by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with EDJ-MED-976a33d5-1 (Mpro-P2724)
Descriptor: 1-[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-1,2'-dioxo-1H-spiro[isoquinoline-4,3'-pyrrolidin]-2(3H)-yl]-N-methylcyclopropane-1-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GMH
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BU of 7gmh by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-90fd5f68-37 (Mpro-P2183)
Descriptor: 3C-like proteinase, 4-[2-(3-chlorophenyl)acetamido]isoquinoline-6-carboxylic acid, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.848 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GLI
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BU of 7gli by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-af1eef35-2 (Mpro-P1982)
Descriptor: 3C-like proteinase, CHLORIDE ION, DIMETHYL SULFOXIDE, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.839 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GN1
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BU of 7gn1 by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with EDJ-MED-8bb691af-6 (Mpro-P2263)
Descriptor: 1-{[(3'S)-6-chloro-1'-(isoquinolin-4-yl)-2'-oxo-1H-spiro[isoquinoline-4,3'-pyrrolidine]-2(3H)-sulfonyl]methyl}cyclopropane-1-carbonitrile, 3C-like proteinase, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.903 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023
7GLY
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BU of 7gly by Molmil
Group deposition SARS-CoV-2 main protease in complex with inhibitors from the COVID Moonshot -- Crystal Structure of SARS-CoV-2 main protease in complex with MAT-POS-5cd9ea36-23 (Mpro-P2057)
Descriptor: (4S)-6-chloro-2-[(2-hydroxyethyl)(methyl)sulfamoyl]-N-(isoquinolin-4-yl)-1,2,3,4-tetrahydroisoquinoline-4-carboxamide, 3C-like proteinase, CHLORIDE ION, ...
Authors:Fearon, D, Aimon, A, Aschenbrenner, J.C, Balcomb, B.H, Bertram, F.K.R, Brandao-Neto, J, Dias, A, Douangamath, A, Dunnett, L, Godoy, A.S, Gorrie-Stone, T.J, Koekemoer, L, Krojer, T, Lithgo, R.M, Lukacik, P, Marples, P.G, Mikolajek, H, Nelson, E, Owen, C.D, Powell, A.J, Rangel, V.L, Skyner, R, Strain-Damerell, C.M, Thompson, W, Tomlinson, C.W.E, Wild, C, Walsh, M.A, von Delft, F.
Deposit date:2023-08-11
Release date:2023-11-08
Last modified:2023-12-06
Method:X-RAY DIFFRACTION (1.805 Å)
Cite:Open science discovery of potent noncovalent SARS-CoV-2 main protease inhibitors.
Science, 382, 2023

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