6ZQW
 
 | | Cryo-EM structure of immature Spondweni virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, prM | | Authors: | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | | Deposit date: | 2020-07-10 | | Release date: | 2021-01-20 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (7.8 Å) | | Cite: | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Nat Commun, 12, 2021
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6ZQJ
 | | Cryo-EM structure of trimeric prME spike of Spondweni virus | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein, prM | | Authors: | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | | Deposit date: | 2020-07-09 | | Release date: | 2021-01-20 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (4.2 Å) | | Cite: | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Nat Commun, 12, 2021
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6ZQV
 | | Cryo-EM structure of mature Spondweni virus | | Descriptor: | 1,2-Distearoyl-sn-glycerophosphoethanolamine, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein | | Authors: | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | | Deposit date: | 2020-07-10 | | Release date: | 2021-01-20 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Nat Commun, 12, 2021
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6XZQ
 | | Influenza C virus polymerase in complex with human ANP32A - Subclass 1 | | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member A, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Fan, H, Carrique, L, Keown, J.R, Grimes, J.M, Fodor, E. | | Deposit date: | 2020-02-05 | | Release date: | 2020-11-25 | | Last modified: | 2024-05-22 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Host ANP32A mediates the assembly of the influenza virus replicase.
Nature, 587, 2020
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6ZQU
 | | Cryo-EM structure of mature Dengue virus 2 at 3.1 angstrom resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein | | Authors: | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | | Deposit date: | 2020-07-10 | | Release date: | 2021-01-20 | | Last modified: | 2021-08-04 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins.
Nat Commun, 12, 2021
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6VVG
 | | Structure of the Cydia pomonella Granulovirus kinase, PK-1 | | Descriptor: | ADENOSINE MONOPHOSPHATE, Arginine kinase | | Authors: | Oliver, M.R, Horne, C.R, Keown, J.R, Murphy, J.M, Metcalf, P. | | Deposit date: | 2020-02-17 | | Release date: | 2021-02-03 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.01 Å) | | Cite: | Granulovirus PK-1 kinase activity relies on a side-to-side dimerization mode centered on the regulatory alpha C helix.
Nat Commun, 12, 2021
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6O5K
 | | Murine TRIM28 Bbox1 domain | | Descriptor: | Transcription intermediary factor 1-beta, ZINC ION | | Authors: | Sun, Y, Keown, J.R, Goldstone, D.C. | | Deposit date: | 2019-03-03 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | A Dissection of Oligomerization by the TRIM28 Tripartite Motif and the Interaction with Members of the Krab-ZFP Family.
J.Mol.Biol., 431, 2019
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6RR7
 | | Influenza A virus (A/NT/60/1968) polymerase Heterotrimer bound to 3'5' vRNA promoter and capped RNA primer | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-D(*(M7G))-R(P*AP*AP*UP*CP*U)-3'), ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-05-17 | | Release date: | 2019-09-04 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (3.01 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6QPF
 | | Influenza A virus Polymerase Heterotrimer A/duck/Fujian/01/2002(H5N1) | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA-directed RNA polymerase catalytic subunit | | Authors: | Fan, H.T, Keown, J.R, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-02-13 | | Release date: | 2019-09-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.634 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6QPG
 | | Influenza A virus Polymerase Heterotrimer A/nt/60/1968(H3N2) in complex with Nanobody NB8205 | | Descriptor: | Nanobody NB8205, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Fan, H.T, Keown, J.R, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-02-13 | | Release date: | 2019-09-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.34 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6QX8
 | | Influenza A virus (A/NT/60/1968) polymerase dimer of heterotrimer in complex with 5' cRNA promoter | | Descriptor: | Polymerase acidic protein, Polymerase basic protein 2, RNA (5'-R(P*AP*GP*CP*AP*AP*AP*AP*GP*CP*AP*GP*A)-3'), ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (4.07 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6QXE
 | | Influenza A virus (A/NT/60/1968) polymerase dimer of hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 | | Descriptor: | Nb8205, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-04 | | Last modified: | 2020-11-18 | | Method: | ELECTRON MICROSCOPY (4.15 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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6QX3
 | | Influenza A virus (A/NT/60/1968) polymerase Hetermotrimer in complex with 3'5' cRNA promoter and Nb8205 | | Descriptor: | Nb8205, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2019-03-07 | | Release date: | 2019-09-04 | | Last modified: | 2024-05-15 | | Method: | ELECTRON MICROSCOPY (3.79 Å) | | Cite: | Structures of influenza A virus RNA polymerase offer insight into viral genome replication.
Nature, 573, 2019
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8R1J
 | | Structure of avian H5N1 influenza A polymerase dimer in complex with human ANP32B. | | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2023-11-02 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
Nat Commun, 15, 2024
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8R1L
 | | Structure of avian H5N1 influenza A polymerase in complex with human ANP32B. | | Descriptor: | Acidic leucine-rich nuclear phosphoprotein 32 family member B, Polymerase acidic protein, Polymerase basic protein 2, ... | | Authors: | Carrique, L, Staller, E, Keown, J.R, Fan, H, Fodor, E, Grimes, J.M. | | Deposit date: | 2023-11-02 | | Release date: | 2024-05-08 | | Last modified: | 2024-05-29 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Structures of H5N1 influenza polymerase with ANP32B reveal mechanisms of genome replication and host adaptation.
Nat Commun, 15, 2024
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6ARH
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5UD6
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5UI3
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5K3Q
 | | Rhesus macaques Trim5alpha Bbox2 domain | | Descriptor: | NITRATE ION, Tripartite motif-containing protein 5,Tripartite motif-containing protein 5, ZINC ION | | Authors: | Keown, J.K, Goldstone, D.C. | | Deposit date: | 2016-05-19 | | Release date: | 2016-07-20 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of the Trim5 alpha Bbox2 domain from rhesus macaques describes a plastic oligomerisation interface.
J.Struct.Biol., 195, 2016
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6HUN
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6I28
 | | Crystal Structure of Cydia Pomonella PTP-2 phosphatase | | Descriptor: | CALCIUM ION, GLYCEROL, ORF98 PTP-2 | | Authors: | Huang, G, Keown, J.P, Oliver, M.R, Metcalf, P. | | Deposit date: | 2018-10-31 | | Release date: | 2019-02-20 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Crystal structure of protein tyrosine phosphatase-2 from Cydia pomonella granulovirus.
Acta Crystallogr.,Sect.F, 75, 2019
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8OKH
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5UGJ
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5UA0
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8EV4
 | | NlpC B3 - Trichomonas Vaginalis | | Descriptor: | Clan CA, family C40, NlpC/P60 superfamily cysteine peptidase | | Authors: | Barnett, M.J, Goldstone, D.C. | | Deposit date: | 2022-10-19 | | Release date: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.3 Å) | | Cite: | NlpC/P60 peptidoglycan hydrolases of Trichomonas vaginalis have complementary activities that empower the protozoan to control host-protective lactobacilli.
Plos Pathog., 19, 2023
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