1SQB
 
 | | Crystal Structure Analysis of Bovine Bc1 with Azoxystrobin | | Descriptor: | Cytochrome b, Cytochrome c1, heme protein, ... | | Authors: | Esser, L, Quinn, B, Li, Y.F, Zhang, M, Elberry, M, Yu, L, Yu, C.A, Xia, D. | | Deposit date: | 2004-03-18 | | Release date: | 2004-09-07 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.69 Å) | | Cite: | Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex
J.Mol.Biol., 341, 2004
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1SQV
 | | Crystal Structure Analysis of Bovine Bc1 with UHDBT | | Descriptor: | 6-HYDROXY-5-UNDECYL-1,3-BENZOTHIAZOLE-4,7-DIONE, Cytochrome b, Cytochrome c1, ... | | Authors: | Esser, L, Quinn, B, Li, Y.F, Zhang, M, Elberry, M, Yu, L, Yu, C.A, Xia, D. | | Deposit date: | 2004-03-19 | | Release date: | 2005-09-06 | | Last modified: | 2021-03-03 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex.
J.Mol.Biol., 341, 2004
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7U9J
 | | Crystal structure of Mesothelin-207 fragment | | Descriptor: | GLYCEROL, Isoform 3 of Mesothelin, SULFATE ION | | Authors: | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | | Deposit date: | 2022-03-10 | | Release date: | 2023-02-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
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7UED
 | | Crystal structure of full length mesothelin bound with MORAb-009 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Isoform 4 of Mesothelin, ... | | Authors: | Zhan, J, Esser, L, Lin, D, Tang, W.K, Xia, D. | | Deposit date: | 2022-03-21 | | Release date: | 2023-02-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Structures of Cancer Antigen Mesothelin and Its Complexes with Therapeutic Antibodies.
Cancer Res Commun, 3, 2023
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5KIW
 | | p97 ND1-L198W in complex with VIMP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2016-06-17 | | Release date: | 2018-03-07 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (3.41 Å) | | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane.
Cell Discov, 3, 2017
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5KIY
 | | p97 ND1-A232E in complex with VIMP | | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Selenoprotein S, ... | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2016-06-17 | | Release date: | 2017-12-20 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane.
Cell Discov, 3, 2017
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5KIU
 | | VCP-interacting membrane protein (VIMP) | | Descriptor: | Selenoprotein S | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2016-06-17 | | Release date: | 2017-12-27 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis for nucleotide-modulated p97 association with the ER membrane.
Cell Discov, 3, 2017
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8T7U
 | | ADP-bound Bcs1 (unsymmetrized) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-06-21 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.74 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8T5U
 | | ATP-1 state of Bcs1 (C7 symmetrized) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-06-14 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.13 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8T14
 | | ADP-bound Bcs1 (C7 symmetrized) | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-06-01 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.18 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8TBY
 | | Apo Bcs1, unsymmetrized | | Descriptor: | Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-06-29 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (4.4 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8TI0
 | | ATP-1 state of Bcs1 (unsymmetrized) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-07-18 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.77 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8TPL
 | | ATP-2 state of Bcs1 (unsymmetrized) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-08-04 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.46 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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8TP1
 | | ATP-2 state of Bcs1 (C7 symmetrized) | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mitochondrial chaperone BCS1 | | Authors: | Zhan, J, Xia, D. | | Deposit date: | 2023-08-04 | | Release date: | 2024-06-05 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3.02 Å) | | Cite: | Conformations of Bcs1L undergoing ATP hydrolysis suggest a concerted translocation mechanism for folded iron-sulfur protein substrate.
Nat Commun, 15, 2024
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6UKS
 | | ATPgammaS bound mBcs1 | | Descriptor: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | | Authors: | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | Deposit date: | 2019-10-05 | | Release date: | 2020-02-05 | | Last modified: | 2020-02-26 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
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6UKP
 | | Apo mBcs1 | | Descriptor: | Mitochondrial chaperone BCS1 | | Authors: | Tang, W.K, Borgnia, M.J, Hsu, A.L, Xia, D. | | Deposit date: | 2019-10-05 | | Release date: | 2020-02-12 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.81 Å) | | Cite: | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
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6U1Y
 | | bcs1 AAA domain | | Descriptor: | MAGNESIUM ION, Mitochondrial chaperone BCS1, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2019-08-17 | | Release date: | 2020-02-05 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Structures of AAA protein translocase Bcs1 suggest translocation mechanism of a folded protein.
Nat.Struct.Mol.Biol., 27, 2020
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6LM3
 | | Neutralization mechanism of a monoclonal antibody targeting a porcine circovirus type 2 Cap protein conformational epitope | | Descriptor: | Capsid protein | | Authors: | Sun, Z, Huang, L, Xia, D, Wei, Y, Sun, E, Zhu, H, Bian, H, Wu, H, Feng, L, Wang, J, Liu, C. | | Deposit date: | 2019-12-24 | | Release date: | 2020-02-12 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (6.7 Å) | | Cite: | Neutralization Mechanism of a Monoclonal Antibody Targeting a Porcine Circovirus Type 2 Cap Protein Conformational Epitope.
J.Virol., 94, 2020
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7TCE
 | | Crystal structure of delta sub IV Rhodobacter Sphaeroides bc1 with the antimalarial drug atovaquone. | | Descriptor: | 1,2-DIHEXANOYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE, 2-[trans-4-(4-chlorophenyl)cyclohexyl]-3-hydroxynaphthalene-1,4-dione, Cytochrome b, ... | | Authors: | Esser, L, Xia, D, Zhou, F. | | Deposit date: | 2021-12-23 | | Release date: | 2023-01-18 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3.85 Å) | | Cite: | Crystal structure of delta sub IV Rhodobacter Sphaeroides bc1 with the antimalarial drug atovaquone.
To Be Published
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7U8C
 | | Crystal structure of Mesothelin C-terminal peptide-MORAb 15B6 FAB complex | | Descriptor: | MORab 15B6 Fab heavy chain, MORab 15B6 Fab light chain, Mesothelin, ... | | Authors: | Zhan, J, Esser, L, Xia, D. | | Deposit date: | 2022-03-08 | | Release date: | 2022-06-08 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.74 Å) | | Cite: | Highly active CAR T cells that bind to a juxtamembrane region of mesothelin and are not blocked by shed mesothelin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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8SDW
 | | Crystal structure of the non-myristoylated mutant [L8K]Arf1 in complex with a GDP analogue | | Descriptor: | ADP-ribosylation factor 1, GUANOSINE-3'-MONOPHOSPHATE-5'-DIPHOSPHATE, MAGNESIUM ION | | Authors: | Rosenberg Jr, E.M, Randazzo, P.A, Esser, L, Xia, D. | | Deposit date: | 2023-04-07 | | Release date: | 2023-06-28 | | Last modified: | 2024-04-24 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Point mutations in Arf1 reveal cooperative effects of the N-terminal extension and myristate for GTPase-activating protein catalytic activity.
Plos One, 19, 2024
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3VAC
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4Y2L
 | | Structure of CFA/I pili major subunit CfaB trimer | | Descriptor: | CALCIUM ION, CFA/I fimbrial subunit B, ISOPROPYL ALCOHOL | | Authors: | Bao, R, Xia, D. | | Deposit date: | 2015-02-10 | | Release date: | 2016-08-10 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.746 Å) | | Cite: | Off-pathway assembly of fimbria subunits is prevented by chaperone CfaA of CFA/I fimbriae from enterotoxigenic E. coli.
Mol. Microbiol., 102, 2016
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5DYG
 | | Structure of p97 N-D1 L198W mutant in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2015-09-24 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.
Sci Rep, 6, 2016
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5DYI
 | | Structure of p97 N-D1 wild-type in complex with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Transitional endoplasmic reticulum ATPase | | Authors: | Tang, W.K, Xia, D. | | Deposit date: | 2015-09-24 | | Release date: | 2016-02-10 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (3.71 Å) | | Cite: | Role of the D1-D2 Linker of Human VCP/p97 in the Asymmetry and ATPase Activity of the D1-domain.
Sci Rep, 6, 2016
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