7VXZ
 
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8HOG
 | | Crystal structure of Bcl-2 in complex with sonrotoclax | | Descriptor: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | Authors: | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | Deposit date: | 2022-12-10 | | Release date: | 2024-01-17 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8HOH
 | | Crystal structure of Bcl-2 G101V in complex with sonrotoclax | | Descriptor: | Apoptosis regulator Bcl-2, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | Authors: | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | Deposit date: | 2022-12-10 | | Release date: | 2024-01-17 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8HOI
 | | Crystal structure of Bcl-2 D103Y in complex with sonrotoclax | | Descriptor: | Apoptosis regulator Bcl-2, FORMIC ACID, ~{N}-[4-[(4-methyl-4-oxidanyl-cyclohexyl)methylamino]-3-nitro-phenyl]sulfonyl-4-[2-[(2~{S})-2-(2-propan-2-ylphenyl)pyrrolidin-1-yl]-7-azaspiro[3.5]nonan-7-yl]-2-(1~{H}-pyrrolo[2,3-b]pyridin-5-yloxy)benzamide | | Authors: | Liu, J, Xu, M, Feng, Y, Hong, Y, Liu, Y. | | Deposit date: | 2022-12-10 | | Release date: | 2024-01-17 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Sonrotoclax overcomes BCL2 G101V mutation-induced venetoclax resistance in preclinical models of hematologic malignancy.
Blood, 143, 2024
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8WEC
 | | Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with BAK1 ectodomain and SCOOP12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEB
 | | Crystal structure of Arabidopsis thaliana MIK2 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MDIS1-interacting receptor like kinase 2 | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WED
 | | Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with BAK1 ectodomain and Fusarium oxysporum SCOOPL | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEF
 | | Crystal structure of Brassica napus MIK2 ectodomain in complex with Fusarium oxysporum SCOOPL | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEI
 | | Crystal structure of Brassica napus MIK2 ectodomain (N393D mutant) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.71 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEG
 | | Crystal structure of Brassica napus MIK2 ectodomain | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEH
 | | Crystal structure of Brassica napus MIK2 ectodomain (N393A mutant) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (3.6 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8WEE
 | | Crystal structure of Arabidopsis thaliana MIK2 ectodomain in complex with SCOOP12 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | Authors: | Wan, L.H, Hu, Y.X, Wu, H.M. | | Deposit date: | 2023-09-17 | | Release date: | 2024-11-06 | | Last modified: | 2024-12-25 | | Method: | X-RAY DIFFRACTION (2.19 Å) | | Cite: | Mechanistic study of SCOOPs recognition by MIK2-BAK1 complex reveals the role of N-glycans in plant ligand-receptor-coreceptor complex formation.
Nat.Plants, 10, 2024
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8JGL
 | | Cryo-EM structure of mClC-3 with AMP | | Descriptor: | ADENOSINE MONOPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-11 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.14 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGS
 | | Cryo-EM structure of apo state mClC-3_I607T | | Descriptor: | H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-04 | | Last modified: | 2025-06-25 | | Method: | ELECTRON MICROSCOPY (3.96 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JEV
 | | Cryo-EM structure of apo state mClC-3 | | Descriptor: | CHLORIDE ION, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-16 | | Release date: | 2024-09-04 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3.06 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGV
 | | Cryo-EM structure of mClC-3_I607T with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-04 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (2.98 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGJ
 | | Cryo-EM structure of mClC-3 with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-20 | | Release date: | 2024-09-04 | | Last modified: | 2025-06-18 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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8JGK
 | | Cryo-EM structure of mClC-3 with ADP | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, H(+)/Cl(-) exchange transporter 3 | | Authors: | Wan, Y.Z.Q, Yang, F. | | Deposit date: | 2023-05-21 | | Release date: | 2024-09-04 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (4.04 Å) | | Cite: | Structural basis of adenine nucleotides regulation and neurodegenerative pathology in ClC-3 exchanger.
Nat Commun, 15, 2024
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7YTJ
 | | Cryo-EM structure of VTC complex | | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, INOSITOL HEXAKISPHOSPHATE, PHOSPHATE ION, ... | | Authors: | Guan, Z.Y, Chen, J, Liu, R.W, Chen, Y.K, Xing, Q, Du, Z.M, Liu, Z. | | Deposit date: | 2022-08-15 | | Release date: | 2023-02-22 | | Last modified: | 2025-07-02 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | The cytoplasmic synthesis and coupled membrane translocation of eukaryotic polyphosphate by signal-activated VTC complex.
Nat Commun, 14, 2023
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3TJC
 | | Co-crystal structure of jak2 with thienopyridine 8 | | Descriptor: | 4-amino-N-methyl-2-[4-(morpholin-4-yl)phenyl]thieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | | Authors: | Huang, X. | | Deposit date: | 2011-08-24 | | Release date: | 2011-11-30 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors.
J.Med.Chem., 54, 2011
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3TJD
 | | co-crystal structure of Jak2 with thienopyridine 19 | | Descriptor: | 4-amino-2-[4-(tert-butylsulfamoyl)phenyl]-N-methylthieno[3,2-c]pyridine-7-carboxamide, Tyrosine-protein kinase JAK2 | | Authors: | Huang, X. | | Deposit date: | 2011-08-24 | | Release date: | 2011-11-30 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Discovery of potent and highly selective thienopyridine janus kinase 2 inhibitors.
J.Med.Chem., 54, 2011
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6K0B
 | | cryo-EM structure of archaeal Ribonuclease P with mature tRNA | | Descriptor: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | | Authors: | Wan, F, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2019-05-05 | | Release date: | 2019-06-19 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.3 Å) | | Cite: | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
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6K0A
 | | cryo-EM structure of an archaeal Ribonuclease P | | Descriptor: | 50S ribosomal protein L7Ae, RPR, Ribonuclease P protein component 1, ... | | Authors: | Wan, F, Lan, P, Wu, J, Lei, M. | | Deposit date: | 2019-05-05 | | Release date: | 2019-06-19 | | Last modified: | 2022-12-21 | | Method: | ELECTRON MICROSCOPY (4.6 Å) | | Cite: | Cryo-electron microscopy structure of an archaeal ribonuclease P holoenzyme.
Nat Commun, 10, 2019
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4WSI
 | | Crystal Structure of PALS1/Crb complex | | Descriptor: | MAGUK p55 subfamily member 5, Protein crumbs | | Authors: | Wei, Z, Li, Y, Zhang, M. | | Deposit date: | 2014-10-28 | | Release date: | 2014-11-26 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (2.95 Å) | | Cite: | Structure of Crumbs tail in complex with the PALS1 PDZ-SH3-GK tandem reveals a highly specific assembly mechanism for the apical Crumbs complex.
Proc.Natl.Acad.Sci.USA, 111, 2014
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3DAT
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