3DAT
Crystal structure of the ternary MTX NADPH complex of Bacillus anthracis dihydrofolate reductase
Summary for 3DAT
Entry DOI | 10.2210/pdb3dat/pdb |
Related | 2QK8 |
Descriptor | Dihydrofolate reductase, METHOTREXATE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... (4 entities in total) |
Functional Keywords | dual-site inhibition, oxidoreductase, pseudo-rossmann fold, adenine nucleotide binding domain |
Biological source | Bacillus anthracis str. |
Total number of polymer chains | 1 |
Total formula weight | 20348.71 |
Authors | Bennett, B.C.,Dealwis, C.G. (deposition date: 2008-05-30, release date: 2009-04-14, Last modification date: 2023-08-30) |
Primary citation | Bennett, B.C.,Wan, Q.,Ahmad, M.F.,Langan, P.,Dealwis, C.G. X-ray structure of the ternary MTX.NADPH complex of the anthrax dihydrofolate reductase: a pharmacophore for dual-site inhibitor design. J.Struct.Biol., 166:162-171, 2009 Cited by PubMed: 19374017PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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