Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0000166 | molecular_function | nucleotide binding |
| A | 0004146 | molecular_function | dihydrofolate reductase activity |
| A | 0005829 | cellular_component | cytosol |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0046452 | biological_process | dihydrofolate metabolic process |
| A | 0046654 | biological_process | tetrahydrofolate biosynthetic process |
| A | 0046655 | biological_process | folic acid metabolic process |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0050661 | molecular_function | NADP binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE MTX A 201 |
| Chain | Residue |
| A | MET6 |
| A | LEU55 |
| A | ARG58 |
| A | PHE96 |
| A | TYR102 |
| A | THR115 |
| A | NDP202 |
| A | HOH229 |
| A | VAL7 |
| A | ALA8 |
| A | LEU21 |
| A | GLU28 |
| A | LEU29 |
| A | VAL32 |
| A | ILE51 |
| A | ARG53 |
| site_id | AC2 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR RESIDUE NDP A 202 |
| Chain | Residue |
| A | VAL7 |
| A | ALA8 |
| A | ILE15 |
| A | ASN19 |
| A | ASN20 |
| A | LEU21 |
| A | TRP23 |
| A | GLY44 |
| A | ARG45 |
| A | LYS46 |
| A | ASN47 |
| A | VAL63 |
| A | THR64 |
| A | ARG65 |
| A | HIS78 |
| A | PHE96 |
| A | GLY97 |
| A | GLY98 |
| A | ALA99 |
| A | GLN100 |
| A | ILE101 |
| A | TYR102 |
| A | LEU104 |
| A | THR125 |
| A | MTX201 |
| A | HOH212 |
| A | HOH224 |
Functional Information from PROSITE/UniProt
| site_id | PS00075 |
| Number of Residues | 23 |
| Details | DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGkdnnLPWrlps.ElqyVkktT |
| Chain | Residue | Details |
| A | VAL14-THR36 | |
Catalytic Information from CSA
| site_id | CSA1 |
| Number of Residues | 2 |
| Details | Annotated By Reference To The Literature 1dhf |
| Chain | Residue | Details |
| A | GLU28 | |
| A | LEU21 | |
