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Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 12 bound to EGFRinsNPG
Descriptor:	1-[3-[7-methoxy-4-[3-(3-methoxyphenyl)-1~{H}-pyrazol-4-yl]quinazolin-6-yl]oxyazetidin-1-yl]propan-1-one, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-06-19
Method:	X-RAY DIFFRACTION (2.523 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

Discovery and Optimisation of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. Compound 18 bound to EGFR[V948R]
Descriptor:	2-methyl-5-[[3-[1-[(3~{S})-1-propanoylpyrrolidin-3-yl]-4-pyridin-4-yl-pyrazol-3-yl]phenoxy]methyl]-3~{H}-isoindol-1-one, Epidermal growth factor receptor
Authors:	Hargreaves, D.
Deposit date:	2023-07-03
Release date:	2024-06-05
Last modified:	2024-06-19
Method:	X-RAY DIFFRACTION (2.13 Å)
Cite:	Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations. J.Med.Chem., 67, 2024

crystal structure of monoclonal antibody MR78 Fab
Descriptor:	SODIUM ION, marberg virus monoclonal antibody MR78 Fab heavy chain, marberg virus monoclonal antibody MR78 Fab light chain
Authors:	Dong, J, Crowe, J.
Deposit date:	2016-05-06
Release date:	2017-11-08
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Role of Non-local Interactions between CDR Loops in Binding Affinity of MR78 Antibody to Marburg Virus Glycoprotein. Structure, 25, 2017