8FAA
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8FA5
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8FA4
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7PUG
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![BU of 7pug by Molmil](/molmil-images/mine/7pug) | GH115 alpha-1,2-glucuronidase in complex with xylopentaose | Descriptor: | CALCIUM ION, CHLORIDE ION, beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose-(1-4)-beta-D-xylopyranose, ... | Authors: | Wilkens, C, Morth, J.P, Polikarpov, I. | Deposit date: | 2021-09-29 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.66 Å) | Cite: | A GH115 alpha-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis. Acta Crystallogr D Struct Biol, 78, 2022
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7PXQ
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![BU of 7pxq by Molmil](/molmil-images/mine/7pxq) | GH115 alpha-1,2-glucuronidase D303A | Descriptor: | CALCIUM ION, xylan alpha-1,2-glucuronidase | Authors: | Wilkens, C, Morth, J.P, Polikarpov, I. | Deposit date: | 2021-10-08 | Release date: | 2022-01-19 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | A GH115 alpha-glucuronidase structure reveals dimerization-mediated substrate binding and a proton wire potentially important for catalysis. Acta Crystallogr D Struct Biol, 78, 2022
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4H7M
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1QLR
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![BU of 1qlr by Molmil](/molmil-images/mine/1qlr) | CRYSTAL STRUCTURE OF THE FAB FRAGMENT OF A HUMAN MONOCLONAL IgM COLD AGGLUTININ | Descriptor: | IGM FAB REGION IV-J(H4)-C (KAU COLD AGGLUTININ), IGM KAPPA CHAIN V-III (KAU COLD AGGLUTININ), alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Carvalho, J.G, Cauerhff, A, Goldbaum, F, Leoni, J, Polikarpov, I. | Deposit date: | 1999-09-11 | Release date: | 2000-09-14 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Three-dimensional structure of the Fab from a human IgM cold agglutinin. J Immunol., 165, 2000
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1XC6
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![BU of 1xc6 by Molmil](/molmil-images/mine/1xc6) | Native Structure Of Beta-Galactosidase from Penicillium sp. in complex with Galactose | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rojas, A.L, Nagem, R.A.P, Neustroev, K.N, Arand, M, Adamska, M, Eneyskaya, E.V, Kulminskaya, A.A, Garratt, R.C, Golubev, A.M, Polikarpov, I. | Deposit date: | 2004-09-01 | Release date: | 2004-11-02 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structures of beta-Galactosidase from Penicillium sp. and its Complex with Galactose J.Mol.Biol., 343, 2004
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1Y9M
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![BU of 1y9m by Molmil](/molmil-images/mine/1y9m) | Crystal structure of exo-inulinase from Aspergillus awamori in spacegroup P212121 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-16 | Release date: | 2004-12-28 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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2P3B
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![BU of 2p3b by Molmil](/molmil-images/mine/2p3b) | Crystal Structure of the subtype B wild type HIV protease complexed with TL-3 inhibitor | Descriptor: | benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, protease | Authors: | Sanches, M, Krauchenco, S, Martins, N.H, Gustchina, A, Wlodawer, A, Polikarpov, I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369, 2007
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2P3C
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![BU of 2p3c by Molmil](/molmil-images/mine/2p3c) | Crystal Structure of the subtype F wild type HIV protease complexed with TL-3 inhibitor | Descriptor: | ACETIC ACID, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, protease | Authors: | Sanches, M, Krauchenco, S, Martins, N.H, Gustchina, A, Wlodawer, A, Polikarpov, I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369, 2007
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2P3D
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![BU of 2p3d by Molmil](/molmil-images/mine/2p3d) | Crystal Structure of the multi-drug resistant mutant subtype F HIV protease complexed with TL-3 inhibitor | Descriptor: | Pol protein, benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate | Authors: | Sanches, M, Krauchenco, S, Martins, N.H, Gustchina, A, Wlodawer, A, Polikarpov, I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369, 2007
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1Y9G
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![BU of 1y9g by Molmil](/molmil-images/mine/1y9g) | Crystal structure of exo-inulinase from Aspergillus awamori complexed with fructose | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-fructofuranose, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-15 | Release date: | 2004-12-21 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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1Y4W
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![BU of 1y4w by Molmil](/molmil-images/mine/1y4w) | Crystal structure of exo-inulinase from Aspergillus awamori in spacegroup P21 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Nagem, R.A.P, Rojas, A.L, Golubev, A.M, Korneeva, O.S, Eneyskaya, E.V, Kulminskaya, A.A, Neustroev, K.N, Polikarpov, I. | Deposit date: | 2004-12-01 | Release date: | 2004-12-14 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Crystal structure of exo-inulinase from Aspergillus awamori: the enzyme fold and structural determinants of substrate recognition J.Mol.Biol., 344, 2004
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2P3A
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![BU of 2p3a by Molmil](/molmil-images/mine/2p3a) | Crystal Structure of the multi-drug resistant mutant subtype B HIV protease complexed with TL-3 inhibitor | Descriptor: | benzyl [(1S,4S,7S,8R,9R,10S,13S,16S)-7,10-dibenzyl-8,9-dihydroxy-1,16-dimethyl-4,13-bis(1-methylethyl)-2,5,12,15,18-pentaoxo-20-phenyl-19-oxa-3,6,11,14,17-pentaazaicos-1-yl]carbamate, protease | Authors: | Sanches, M, Krauchenco, S, Martins, N.H, Gustchina, A, Wlodawer, A, Polikarpov, I. | Deposit date: | 2007-03-08 | Release date: | 2007-04-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structural Characterization of B and non-B Subtypes of HIV-Protease: Insights into the Natural Susceptibility to Drug Resistance Development. J.Mol.Biol., 369, 2007
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3SZ1
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![BU of 3sz1 by Molmil](/molmil-images/mine/3sz1) | Human PPAR gamma ligand binding domain in complex with luteolin and myristic acid | Descriptor: | 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-chromen-4-one, MYRISTIC ACID, Peroxisome proliferator-activated receptor gamma, ... | Authors: | Puhl, A.C, Bernardes, A, Polikarpov, I. | Deposit date: | 2011-07-18 | Release date: | 2012-03-21 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mode of peroxisome proliferator-activated receptor gamma activation by luteolin. Mol.Pharmacol., 81, 2012
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3TKM
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![BU of 3tkm by Molmil](/molmil-images/mine/3tkm) | Crystal structure PPAR delta binding GW0742 | Descriptor: | GLYCEROL, Peroxisome proliferator-activated receptor delta, {4-[({2-[3-fluoro-4-(trifluoromethyl)phenyl]-4-methyl-1,3-thiazol-5-yl}methyl)sulfanyl]-2-methylphenoxy}acetic acid | Authors: | Trivella, D.B.B, Batista, F.H, Polikarpov, I. | Deposit date: | 2011-08-27 | Release date: | 2012-07-04 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.953 Å) | Cite: | Structural Insights into Human Peroxisome Proliferator Activated Receptor Delta (PPAR-Delta) Selective Ligand Binding. Plos One, 7, 2012
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1IG8
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![BU of 1ig8 by Molmil](/molmil-images/mine/1ig8) | Crystal Structure of Yeast Hexokinase PII with the correct amino acid sequence | Descriptor: | SULFATE ION, hexokinase PII | Authors: | Kuser, P.R, Krauchenco, S, Antunes, O.A, Polikarpov, I. | Deposit date: | 2001-04-17 | Release date: | 2001-05-02 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The high resolution crystal structure of yeast hexokinase PII with the correct primary sequence provides new insights into its mechanism of action. J.Biol.Chem., 275, 2000
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1JV4
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![BU of 1jv4 by Molmil](/molmil-images/mine/1jv4) | Crystal structure of recombinant major mouse urinary protein (rmup) at 1.75 A resolution | Descriptor: | 2-(SEC-BUTYL)THIAZOLE, CADMIUM ION, Major urinary protein 2 | Authors: | Kuser, P.R, Franzoni, L, Ferrari, E, Spisni, A, Polikarpov, I. | Deposit date: | 2001-08-28 | Release date: | 2001-12-05 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | The X-ray structure of a recombinant major urinary protein at 1.75 A resolution. A comparative study of X-ray and NMR-derived structures. Acta Crystallogr.,Sect.D, 57, 2001
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6WQW
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![BU of 6wqw by Molmil](/molmil-images/mine/6wqw) | Thermobacillus composti GH10 xylanase | Descriptor: | Beta-xylanase, beta-D-xylopyranose | Authors: | Briganti, L, Polikarpov, I. | Deposit date: | 2020-04-29 | Release date: | 2021-04-28 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Transformation of xylan into value-added biocommodities using Thermobacillus composti GH10 xylanase. Carbohydr Polym, 247, 2020
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6WGD
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![BU of 6wgd by Molmil](/molmil-images/mine/6wgd) | Crystal structure of a 6-phospho-beta-glucosidase from Bacillus licheniformis | Descriptor: | 1,2-ETHANEDIOL, 6-phospho-beta-glucosidase | Authors: | Liberato, M.V, Popov, A, Polikarpov, I. | Deposit date: | 2020-04-05 | Release date: | 2020-11-25 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | X-ray Structure, Bioinformatics Analysis, and Substrate Specificity of a 6-Phospho-beta-glucosidase Glycoside Hydrolase 1 Enzyme from Bacillus licheniformis . J.Chem.Inf.Model., 60, 2020
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1NNS
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![BU of 1nns by Molmil](/molmil-images/mine/1nns) | L-asparaginase of E. coli in C2 space group and 1.95 A resolution | Descriptor: | ASPARTIC ACID, L-asparaginase II | Authors: | Sanches, M, Barbosa, J.A.R.G, de Oliveira, R.T, Neto, J.A.A, Polikarpov, I. | Deposit date: | 2003-01-14 | Release date: | 2003-03-11 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structural comparison of Escherichia coli L-asparaginase in two monoclinic space groups. Acta Crystallogr.,Sect.D, 59, 2003
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6WPX
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6WPY
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3NEE
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![BU of 3nee by Molmil](/molmil-images/mine/3nee) | Wild type human transthyretin (TTR) complexed with GC-1 (TTRwt:GC-1) | Descriptor: | GLYCEROL, Transthyretin, {4-[4-hydroxy-3-(1-methylethyl)benzyl]-3,5-dimethylphenoxy}acetic acid | Authors: | Trivella, D.B.B, Polikarpov, I. | Deposit date: | 2010-06-08 | Release date: | 2010-11-24 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | The binding of synthetic triiodo l-thyronine analogs to human transthyretin: molecular basis of cooperative and non-cooperative ligand recognition. J.Struct.Biol., 173, 2011
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