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Crystal Structure of Mtb Pks13 Thioesterase domain in complex with inhibitor TAM1
Descriptor:	Polyketide synthase Pks13 (Termination polyketide synthase), ethyl 5-hydroxy-4-[(4-methylpiperidin-1-yl)methyl]-2-phenyl-1-benzofuran-3-carboxylate
Authors:	Aggarwal, A, Sacchettini, J.C.
Deposit date:	2017-03-08
Release date:	2017-07-05
Last modified:	2023-10-04
Method:	X-RAY DIFFRACTION (1.936 Å)
Cite:	Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13. Cell, 170, 2017

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:	4-METHOXY-2,3,6-TRIMETHYL-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, CHLORIDE ION, GLYCEROL, ...
Authors:	Robinson, D.A, Brand, S, Fairlamb, A.H, Ferguson, M.A.J, Frearson, J.A, Wyatt, P.G.
Deposit date:	2011-09-29
Release date:	2011-12-21
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (2.31 Å)
Cite:	Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012

CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND
Descriptor:	4-BROMO-2,6-DICHLORO-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BENZENESULFONAMIDE, CHLORIDE ION, GLYCEROL, ...
Authors:	Robinson, D.A, Brand, S, Fairlamb, A.H, Ferguson, M.A.J, Frearson, J.A, Wyatt, P.G.
Deposit date:	2011-09-29
Release date:	2011-12-21
Last modified:	2023-12-20
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012