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Estrogen Receptor Alpha Ligand Binding Domain in Complex with a Methylated Lasofoxifene Derivative That Increases Receptor Resonance Time in the Nucleus of Breast Cancer Cells
Descriptor:	(5R,6S)-5-(4-{2-[(2R)-2-methylpyrrolidin-1-yl]ethoxy}phenyl)-6-phenyl-5,6,7,8-tetrahydronaphthalen-2-ol, Estrogen receptor
Authors:	Hosfield, D.J, Greene, G.L, Fanning, S.W.
Deposit date:	2022-03-31
Release date:	2022-06-15
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022

Estrogen Receptor Alpha Ligand Binding Domain Y537S Mutant in Complex with RU39411
Descriptor:	11alpha-{4-[2-(dimethylamino)ethoxy]phenyl}estra-1(10),2,4-triene-3,17beta-diol, Estrogen receptor
Authors:	Fanning, S.W, Greene, G.L.
Deposit date:	2022-03-30
Release date:	2022-05-04
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022

Estrogen Receptor Alpha Ligand Binding Domain in Complex with Raloxifene
Descriptor:	Estrogen receptor, RALOXIFENE
Authors:	Fanning, S.W.
Deposit date:	2020-10-02
Release date:	2020-11-18
Last modified:	2023-10-18
Method:	X-RAY DIFFRACTION (1.834 Å)
Cite:	Stereospecific lasofoxifene derivatives reveal the interplay between estrogen receptor alpha stability and antagonistic activity in ESR1 mutant breast cancer cells. Elife, 11, 2022