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6BMT
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BU of 6bmt by Molmil
Crystal Structure of a Recombinant form of Human Myeloperoxidase Bound to an Inhibitor from Staphylococcus delphini
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, CHLORIDE ION, ...
Authors:Ploscariu, N.T, Geisbrecht, B.V.
Deposit date:2017-11-15
Release date:2018-01-03
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Identification and structural characterization of a novel myeloperoxidase inhibitor from Staphylococcus delphini.
Arch. Biochem. Biophys., 645, 2018
2NOJ
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BU of 2noj by Molmil
Crystal structure of Ehp / C3d complex
Descriptor: Complement C3, Efb homologous protein
Authors:Hammel, M, Geisbrecht, B.V.
Deposit date:2006-10-25
Release date:2007-08-14
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Characterization of Ehp, a Secreted Complement Inhibitory Protein from Staphylococcus aureus.
J.Biol.Chem., 282, 2007
7S0R
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BU of 7s0r by Molmil
Crystal Structure of a Complement Factor H-binding Fragment within the B75KN Region of the Group B Streptococcus Beta Antigen C Protein
Descriptor: C protein beta antigen
Authors:Xu, X, Geisbrecht, B.V.
Deposit date:2021-08-31
Release date:2021-12-15
Last modified:2022-06-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Group B Streptococcus Surface Protein beta : Structural Characterization of a Complement Factor H-Binding Motif and Its Contribution to Immune Evasion.
J Immunol., 208, 2022
1SZH
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BU of 1szh by Molmil
Crystal Structure of C. elegans HER-1
Descriptor: ACETATE ION, Her-1 protein
Authors:Hamaoka, B.Y, Dann III, C.E, Geisbrecht, B.V, Leahy, D.J.
Deposit date:2004-04-05
Release date:2004-08-10
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Crystal structure of Caenorhabditis elegans HER-1 and characterization of the interaction between HER-1 and TRA-2A.
Proc.Natl.Acad.Sci.USA, 101, 2004
3I86
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BU of 3i86 by Molmil
Crystal structure of the P60 Domain from M. avium subspecies paratuberculosis antigen MAP1204
Descriptor: ISOPROPYL ALCOHOL, Putative uncharacterized protein
Authors:Ramyar, K.X, Lingle, C.K, McWhorter, W.J, Bouyain, S, Bannantine, J.P, Geisbrecht, B.V.
Deposit date:2009-07-09
Release date:2010-07-21
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Atypical structural features of two P60 family members from Mycobacterium avium subspecies paratuberculosis
To be Published
3GT2
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BU of 3gt2 by Molmil
Crystal Structure of the P60 Domain from M. avium paratuberculosis Antigen MAP1272c
Descriptor: 1,2-ETHANEDIOL, Putative uncharacterized protein, SULFATE ION
Authors:Ramyar, K.X, Lingle, C.K, McWhorter, W.J, Bouyain, S, Bannantine, J.P, Geisbrecht, B.V.
Deposit date:2009-03-27
Release date:2010-04-07
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Crystal Structures of Two P60-Family Antigens from Mycobacterium Avium Paratuberculosis
To be Published
8D4O
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BU of 8d4o by Molmil
Crystal Structure of the Neutrophil Serine Protease Inhibitor Eap1 from S. aureus
Descriptor: Extracellular Adherence Protein, SODIUM ION
Authors:Gido, C.D, Geisbrecht, B.V.
Deposit date:2022-06-02
Release date:2022-12-21
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8D4V
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BU of 8d4v by Molmil
Crystal Structure of Cathepsin G Inhibited by Eap2 from S. aureus
Descriptor: Cathepsin G, C-terminal truncated form, Extracellular Adherence Protein, ...
Authors:Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2022-06-02
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8D4U
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BU of 8d4u by Molmil
Crystal Structure of Neutrophil Elastase Inhibited by Eap2 from S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, ...
Authors:Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2022-06-02
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8D4Q
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BU of 8d4q by Molmil
Crystal Structure of Neutrophil Elastase Inhibited by Eap1 from S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Extracellular Adherence Protein, Neutrophil elastase
Authors:Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2022-06-02
Release date:2022-12-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
8D4S
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BU of 8d4s by Molmil
Crystal Structure of Cathepsin G Inhibited by Eap1 from S. aureus
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin G, C-terminal truncated form, ...
Authors:Gido, C.D, Herdendorf, T.J, Geisbrecht, B.V.
Deposit date:2022-06-02
Release date:2022-12-21
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Characterization of two distinct neutrophil serine protease-binding modes within a Staphylococcus aureus innate immune evasion protein family.
J.Biol.Chem., 299, 2023
4NZL
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BU of 4nzl by Molmil
Extracellular proteins of Staphylococcus aureus inhibit the neutrophil serine proteases
Descriptor: Neutrophil elastase, Uncharacterized protein, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[beta-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose
Authors:Stapels, D.A.C, von Koeckritz-Blickwede, M, Ramyar, K.X, Bischoff, M, Milder, F, Ruyken, M, Scheepmaker, L, McWhorter, W.J, Herrmann, M, van Kessel, K.P.M, Geisbrecht, B.V, Rooijakkers, S.H.M.
Deposit date:2013-12-12
Release date:2014-08-20
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Staphylococcus aureus secretes a unique class of neutrophil serine protease inhibitors.
Proc.Natl.Acad.Sci.USA, 111, 2014
8GDG
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BU of 8gdg by Molmil
Solution structure of the Neutrophil Serine Protease Inhibitor, EapH2
Descriptor: Cell surface like-protein Map-w
Authors:Mishra, N.B, Geisbrecht, B.V, Prakash, O.
Deposit date:2023-03-05
Release date:2023-04-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J.Biol.Chem., 299, 2023
8GDH
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BU of 8gdh by Molmil
Solution structure of the Neutrophil Serine Protease Inhibitor, EapH1
Descriptor: Cell surface protein map-w
Authors:Mishra, N.B, Geisbrecht, B.V, Prakash, O.
Deposit date:2023-03-05
Release date:2023-04-26
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J.Biol.Chem., 299, 2023
8G24
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BU of 8g24 by Molmil
Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 5.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, MAP domain-containing protein, ...
Authors:Mishra, N.B, Geisbrecht, B.V.
Deposit date:2023-02-03
Release date:2023-04-26
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J.Biol.Chem., 299, 2023
8G25
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BU of 8g25 by Molmil
Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 7.5
Descriptor: Cathepsin-G, MAP domain-containing protein, Neutrophil elastase
Authors:Mishra, N.B, Geisbrecht, B.V.
Deposit date:2023-02-03
Release date:2023-04-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J.Biol.Chem., 299, 2023
8G26
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BU of 8g26 by Molmil
Crystal Structure of Cathepsin-G and Neutrophil Elastase Inhibited by S. aureus EapH2 at pH 8.5
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cathepsin-G, ...
Authors:Mishra, N.B, Geisbrecht, B.V.
Deposit date:2023-02-03
Release date:2023-04-26
Last modified:2023-10-25
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Simultaneous inhibition of two neutrophil serine proteases by the S. aureus innate immune evasion protein EapH2.
J.Biol.Chem., 299, 2023
5VJ0
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BU of 5vj0 by Molmil
Crystal Structure of heme-containing DyP Type Peroxidase from Enterobacter lignolyticus
Descriptor: Dyp-type peroxidase family, PROTOPORPHYRIN IX CONTAINING FE
Authors:Meekins, D.A, Li, P, Geisbrecht, B.V.
Deposit date:2017-04-17
Release date:2017-08-16
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.93 Å)
Cite:Mechanistic Insights into Dye-Decolorizing Peroxidase Revealed by Solvent Isotope and Viscosity Effects.
ACS Catal, 7, 2017
8TE5
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BU of 8te5 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
8TE6
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BU of 8te6 by Molmil
Crystal structure of a multiple lysine-to-arginine substitution mutant of the human CRIg C3b-binding domain
Descriptor: V-set and immunoglobulin domain-containing protein 4
Authors:Abram, T.G, Geisbrecht, B.V.
Deposit date:2023-07-05
Release date:2023-07-12
Last modified:2024-01-24
Method:X-RAY DIFFRACTION (1.251 Å)
Cite:New Insights into the Complement Receptor of the Ig Superfamily Obtained from Structural and Functional Studies on Two Mutants.
Immunohorizons, 7, 2023
5UZU
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BU of 5uzu by Molmil
Immune evasion by a Staphylococcal Peroxidase Inhibitor that blocks myeloperoxidase
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ...
Authors:de Jong, N, Geisbrecht, B.V, van Strijp, J, Haas, P, Nijland, R, Ramyar, K, Fevre, C, Guerra, F, Voyich-Kane, J, van Kessel, C, Garcia, B.
Deposit date:2017-02-27
Release date:2017-07-26
Last modified:2023-11-15
Method:X-RAY DIFFRACTION (2.403 Å)
Cite:Immune evasion by a staphylococcal inhibitor of myeloperoxidase.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
7JTQ
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BU of 7jtq by Molmil
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 31 Bases
Descriptor: Complement factor B, DNA (32-MER)
Authors:Xu, X, Geisbrecht, B.V.
Deposit date:2020-08-18
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
J Immunol., 206, 2021
7JTN
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BU of 7jtn by Molmil
Human Complement Factor B Inhibited by a Slow Off-Rate Modified Aptamer of 29 Bases
Descriptor: Complement factor B, DNA (30-MER)
Authors:Xu, X, Geisbrecht, B.V.
Deposit date:2020-08-18
Release date:2020-12-09
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Inhibition of the Complement Alternative Pathway by Chemically Modified DNA Aptamers That Bind with Picomolar Affinity to Factor B.
J Immunol., 206, 2021
4DU7
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BU of 4du7 by Molmil
Crystal structure of Staphylococcus epidermidis mevalonate diphosphate decarboxylase complexed with substrate mevalonate diphosphate
Descriptor: (3R)-3-HYDROXY-5-{[(R)-HYDROXY(PHOSPHONOOXY)PHOSPHORYL]OXY}-3-METHYLPENTANOIC ACID, FORMIC ACID, Mevalonate diphosphate decarboxylase
Authors:Barta, M.L, McWhorter, W.J, Geisbrecht, B.V.
Deposit date:2012-02-21
Release date:2012-07-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.201 Å)
Cite:Structural basis for nucleotide binding and reaction catalysis in mevalonate diphosphate decarboxylase.
Biochemistry, 51, 2012
4H6H
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BU of 4h6h by Molmil
Crystal Structure of Staphylococcal Complement Inhibitor SCIN-B(4-85)
Descriptor: Fibrinogen-binding protein
Authors:Garcia, B.L, Geisbrecht, B.V.
Deposit date:2012-09-19
Release date:2012-12-19
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2.5024 Å)
Cite:A Structurally Dynamic N-terminal Helix Is a Key Functional Determinant in Staphylococcal Complement Inhibitor (SCIN) Proteins.
J.Biol.Chem., 288, 2013

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