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High resolution crystal structure of human Rab9 GTPase: a novel antiviral drug target
Descriptor:	GUANOSINE-5'-DIPHOSPHATE, Ras-related protein Rab-9A
Authors:	Chen, L, DiGiammarino, E, Zhou, X.E, Wang, Y, Toh, D, Hodge, T.W, Meehan, E.J.
Deposit date:	2004-07-16
Release date:	2004-09-14
Last modified:	2023-10-25
Method:	X-RAY DIFFRACTION (1.25 Å)
Cite:	High resolution crystal structure of human Rab9 GTPase: A novel antiviral drug target J.Biol.Chem., 279, 2004

2Z8P

Structural basis for the catalytic mechanism of phosphothreonine lyase
Descriptor:	(GLY)(GLU)(ALA)(TPO)(VAL)(PTR)(ALA), 27.5 kDa virulence protein
Authors:	Chen, L, Wang, H, Gu, L, Huang, N, Zhou, J.M, Chai, J.
Deposit date:	2007-09-07
Release date:	2007-12-18
Last modified:	2024-11-20
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural basis for the catalytic mechanism of phosphothreonine lyase. Nat.Struct.Mol.Biol., 15, 2008

1VJK

Putative molybdopterin converting factor, subunit 1 from Pyrococcus furiosus, Pfu-562899-001
Descriptor:	molybdopterin converting factor, subunit 1
Authors:	Chen, L, Liu, Z.J, Tempel, W, Shah, A, Lee, D, Rose, J.P, Eneh, J.C, Hopkins, R.C, Jenney Jr, F.E, Lee, H.S, Li, T, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Richardson, D.C, Richardson, J.S, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:	2004-03-10
Release date:	2004-08-10
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (1.51 Å)
Cite:	Putative molybdopterin converting factor, subunit 1 from Pyrococcus furiosus, Pfu-562899-001 ' To be published

1XX7

Conserved hypothetical protein from Pyrococcus furiosus Pfu-403030-001
Descriptor:	NICKEL (II) ION, UNKNOWN ATOM OR ION, oxetanocin-like protein
Authors:	Chen, L, Tempel, W, Habel, J, Zhou, W, Nguyen, D, Chang, S.-H, Lee, D, Kelley, L.-L.C, Dillard, B.D, Liu, Z.-J, Bridger, S, Eneh, J.C, Hopkins, R.C, Jenney Jr, F.E, Lee, H.-S, Li, T, Poole II, F.L, Shah, C, Sugar, F.J, Adams, M.W.W, Arendall III, W.B, Richardson, J.S, Richardson, D.C, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:	2004-11-04
Release date:	2004-12-28
Last modified:	2024-02-14
Method:	X-RAY DIFFRACTION (2.261 Å)
Cite:	Conserved hypothetical protein from Pyrococcus furiosus Pfu-403030-001 To be published

1A02

STRUCTURE OF THE DNA BINDING DOMAINS OF NFAT, FOS AND JUN BOUND TO DNA
Descriptor:	AP-1 FRAGMENT FOS, AP-1 FRAGMENT JUN, DNA (5'-D(DAPDAPDCPDTPDAPDTPDGPDAPDAPDAPDCPDAPDAPDAPDTPDTPDTPDTPDCPDC)-3'), ...
Authors:	Chen, L, Glover, J.N.M, Hogan, P.G, Rao, A, Harrison, S.C.
Deposit date:	1997-12-08
Release date:	1998-05-27
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.7 Å)
Cite:	Structure of the DNA-binding domains from NFAT, Fos and Jun bound specifically to DNA. Nature, 392, 1998

1B3D

STROMELYSIN-1
Descriptor:	CALCIUM ION, N-[[2-METHYL-4-HYDROXYCARBAMOYL]BUT-4-YL-N]-BENZYL-P-[PHENYL]-P-[METHYL]PHOSPHINAMID, STROMELYSIN-1, ...
Authors:	Chen, L, Rydel, T.J, Dunaway, C.M, Pikul, S, Dunham, K.M, Gu, F, Barnett, B.L.
Deposit date:	1998-12-09
Release date:	1999-12-10
Last modified:	2023-12-27
Method:	X-RAY DIFFRACTION (2.3 Å)
Cite:	Crystal structure of the stromelysin catalytic domain at 2.0 A resolution: inhibitor-induced conformational changes. J.Mol.Biol., 293, 1999

1ZLM

Crystal structure of the SH3 domain of human osteoclast stimulating factor
Descriptor:	Osteoclast stimulating factor 1
Authors:	Chen, L, Wang, Y, Wells, D, Toh, D, Harold, H, Zhou, J, DiGiammarino, E, Meehan, E.J.
Deposit date:	2005-05-06
Release date:	2006-05-16
Last modified:	2023-08-23
Method:	X-RAY DIFFRACTION (1.07 Å)
Cite:	Structure of the SH3 domain of human osteoclast-stimulating factor at atomic resolution. Acta Crystallogr.,Sect.F, 62, 2006

1DKD

CRYSTAL STRUCTURE OF A GROEL (APICAL DOMAIN) AND A DODECAMERIC PEPTIDE COMPLEX
Descriptor:	12-MER PEPTIDE, GROEL
Authors:	Chen, L, Sigler, P.B.
Deposit date:	1999-12-07
Release date:	2000-01-12
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell(Cambridge,Mass.), 99, 1999

1DK7

CRYSTAL STRUCTURE OF AN ISOLATED APICAL DOMAIN OF GROEL
Descriptor:	GROEL
Authors:	Chen, L, Sigler, P.B.
Deposit date:	1999-12-06
Release date:	2000-01-05
Last modified:	2024-02-07
Method:	X-RAY DIFFRACTION (2.02 Å)
Cite:	The crystal structure of a GroEL/peptide complex: plasticity as a basis for substrate diversity. Cell(Cambridge,Mass.), 99, 1999

1PSA

STRUCTURE OF A PEPSIN(SLASH)RENIN INHIBITOR COMPLEX REVEALS A NOVEL CRYSTAL PACKING INDUCED BY MINOR CHEMICAL ALTERATIONS IN THE INHIBITOR
Descriptor:	N-(ethoxycarbonyl)-L-leucyl-N-[(1R,2S,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-leucinamide, PEPSIN A
Authors:	Chen, L, Abad-Zapatero, C.
Deposit date:	1991-10-22
Release date:	1994-01-31
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (2.9 Å)
Cite:	Structure of a pepsin/renin inhibitor complex reveals a novel crystal packing induced by minor chemical alterations in the inhibitor. Acta Crystallogr.,Sect.B, 48, 1992

1PN9

Crystal structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae
Descriptor:	Glutathione S-transferase 1-6, S-HEXYLGLUTATHIONE
Authors:	Chen, L, Hall, P.R, Zhou, X.E, Ranson, H, Hemingway, J, Meehan, E.J.
Deposit date:	2003-06-12
Release date:	2003-12-09
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structure of an insect delta-class glutathione S-transferase from a DDT-resistant strain of the malaria vector Anopheles gambiae. Acta Crystallogr.,Sect.D, 59, 2003

1QWK

Structural genomics of Caenorhabditis Elegans: Hypothetical 35.2 kDa protein (aldose reductase family member)
Descriptor:	aldo-keto reductase family 1 member C1
Authors:	Chen, L, Zhou, X.E, Meehan, E.J, Symersky, J, Lu, S, Li, S, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:	2003-09-02
Release date:	2003-09-16
Last modified:	2023-08-16
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Structural genomics of Caenorhabditis Elegans: Hypothetical 35.2 kDa protein (aldose reductase family member) To be published

3MCA

Structure of the Dom34-Hbs1 Complex and implications for its role in No-Go decay
Descriptor:	Elongation factor 1 alpha-like protein, Protein dom34
Authors:	Chen, L, Song, H.
Deposit date:	2010-03-28
Release date:	2010-10-06
Last modified:	2024-03-20
Method:	X-RAY DIFFRACTION (2.74 Å)
Cite:	Structure of the Dom34-Hbs1 complex and implications for no-go decay Nat.Struct.Mol.Biol., 17, 2010

2KNO

NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1)
Descriptor:	Tensin-like C1 domain-containing phosphatase
Authors:	Chen, L, Feng, R, Liu, C, Zhu, G.
Deposit date:	2009-08-27
Release date:	2010-09-01
Last modified:	2024-05-01
Method:	SOLUTION NMR
Cite:	NMR Solution Structure of SH2 Domain of the Human Tensin Like C1 Domain Containing Phosphatase (TENC1) To be Published

2JTK

A functional domain of a Wnt signal protein
Descriptor:	Dickkopf-related protein 2
Authors:	Chen, L, Shao, Y, Huang, J, Zheng, J.
Deposit date:	2007-08-02
Release date:	2008-07-08
Last modified:	2024-11-06
Method:	SOLUTION NMR
Cite:	Structural insight into the mechanisms of wnt signaling antagonism by dkk J.Biol.Chem., 283, 2008

2ICU

Crystal Structure of Hypothetical Protein YedK From Escherichia coli
Descriptor:	Hypothetical protein yedK
Authors:	Chen, L, Liu, Z.J, Li, Y, Zhao, M, Rose, J, Ebihara, A, Yokoyama, S, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative, RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2006-09-13
Release date:	2006-11-07
Last modified:	2024-10-30
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Crystal Structure of Hypothetical Protein YedK From Escherichia coli To be Published

2M1N

Solution structure of a chaperone in type III secretion system
Descriptor:	Type III secretion system filament chaperone CesA
Authors:	Chen, L, Economou, A, Kalodimos, C.
Deposit date:	2012-12-03
Release date:	2013-04-10
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Substrate-Activated Conformational Switch on Chaperones Encodes a Targeting Signal in Type III Secretion. Cell Rep, 3, 2013

3WQW

Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)6
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:	Chen, L, Zhou, Y, Yang, Q.
Deposit date:	2014-02-03
Release date:	2014-05-28
Last modified:	2024-11-13
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors. J.Biol.Chem., 289, 2014

3WQV

Crystal structure of Ostrinia furnacalis Group I chitinase catalytic domain in complex with a(GlcN)5
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose-(1-4)-2-amino-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
Authors:	Chen, L, Zhou, Y, Yang, Q.
Deposit date:	2014-02-03
Release date:	2014-05-28
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (2.043 Å)
Cite:	Fully deacetylated chitooligosaccharides act as efficient glycoside hydrolase family 18 chitinase inhibitors. J.Biol.Chem., 289, 2014

2LHK

Structural analysis of a chaperone in type III secretion system
Descriptor:	L0052
Authors:	Chen, L, Economou, A, Kalodimos, C.G.
Deposit date:	2011-08-11
Release date:	2011-12-28
Last modified:	2024-05-15
Method:	SOLUTION NMR
Cite:	Structural instability tuning as a regulatory mechanism in protein-protein interactions. Mol.Cell, 44, 2011

4NZ8

Crystal structure of porcine aminopeptidase-N complexed with cleaved poly-alanine
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
Authors:	Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:	2013-12-11
Release date:	2013-12-25
Last modified:	2024-11-27
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012

4NAQ

Crystal structure of porcine aminopeptidase-N complexed with poly-alanine
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Aminopeptidase N, ...
Authors:	Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:	2013-10-22
Release date:	2013-12-04
Last modified:	2024-11-27
Method:	X-RAY DIFFRACTION (2.1 Å)
Cite:	Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012

4HOM

Crystal structure of porcine aminopeptidase-N complexed with substance P
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:	Chen, L, Lin, Y.L, Peng, G, Li, F.
Deposit date:	2012-10-22
Release date:	2012-10-31
Last modified:	2024-10-16
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structural basis for multifunctional roles of mammalian aminopeptidase N. Proc.Natl.Acad.Sci.USA, 109, 2012

2PX7

Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8
Descriptor:	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase
Authors:	Chen, L, Tsukuda, M, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Chen, L.-Q, Liu, Z.-J, Lee, D, Chang, S.-H, Nguyen, D, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2007-05-14
Release date:	2007-06-12
Last modified:	2023-08-30
Method:	X-RAY DIFFRACTION (2.2 Å)
Cite:	Crystal structure of 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase from Thermus thermophilus HB8. To be Published

2PG0

Crystal structure of acyl-CoA dehydrogenase from Geobacillus kaustophilus
Descriptor:	Acyl-CoA dehydrogenase, FLAVIN-ADENINE DINUCLEOTIDE
Authors:	Chen, L, Chen, L.-Q, Ebihara, A, Shinkai, A, Kuramitsu, S, Yokoyama, S, Zhao, M, Li, Y, Fu, Z.-Q, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG), RIKEN Structural Genomics/Proteomics Initiative (RSGI)
Deposit date:	2007-04-06
Release date:	2007-05-08
Last modified:	2024-02-21
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Crystal structure of acyl-CoA dehydrogenase from G. kaustophilus To be Published

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