4ZO1
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![BU of 4zo1 by Molmil](/molmil-images/mine/4zo1) | Crystal Structure of the T3-bound TR-beta Ligand-binding Domain in complex with RXR-alpha | Descriptor: | 3,5,3'TRIIODOTHYRONINE, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha, ... | Authors: | Bruning, J.B, Kojetin, D.J, Matta-Camacho, E, Hughes, T.S, Srinivasan, S, Nwachukwu, J.C, Cavett, V, Nowak, J, Chalmers, M.J, Marciano, D.P, Kamenecka, T.M, Rance, M, Shulman, A.I, Mangelsdorf, D.J, Griffin, P.R, Nettles, K.W. | Deposit date: | 2015-05-05 | Release date: | 2015-09-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.221 Å) | Cite: | Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nat Commun, 6, 2015
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5TDC
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![BU of 5tdc by Molmil](/molmil-images/mine/5tdc) | Crystal structure of the human UBR-box domain from UBR1 in complex with monomethylated arginine peptide. | Descriptor: | E3 ubiquitin-protein ligase UBR1, NMM-ILE-PHE-SER peptide, SULFATE ION, ... | Authors: | Kozlov, G, Munoz-Escobar, J, Matta-Camacho, E, Gehring, K. | Deposit date: | 2016-09-19 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.607 Å) | Cite: | Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase. Structure, 25, 2017
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2KBW
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![BU of 2kbw by Molmil](/molmil-images/mine/2kbw) | Solution Structure of human Mcl-1 complexed with human Bid_BH3 peptide | Descriptor: | BH3-interacting domain death agonist, Induced myeloid leukemia cell differentiation protein Mcl-1 | Authors: | Liu, Q, Moldoveanu, T, Sprules, T, Matta-Camacho, E, Mansur-Azzam, N, Gehring, K. | Deposit date: | 2008-12-09 | Release date: | 2009-12-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Apoptotic regulation by MCL-1 through heterodimerization. J.Biol.Chem., 285, 2010
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3NY1
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![BU of 3ny1 by Molmil](/molmil-images/mine/3ny1) | Structure of the ubr-box of the UBR1 ubiquitin ligase | Descriptor: | E3 ubiquitin-protein ligase UBR1, ZINC ION | Authors: | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | Deposit date: | 2010-07-14 | Release date: | 2010-08-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.085 Å) | Cite: | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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3NY2
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![BU of 3ny2 by Molmil](/molmil-images/mine/3ny2) | Structure of the ubr-box of UBR2 ubiquitin ligase | Descriptor: | E3 ubiquitin-protein ligase UBR2, ZINC ION | Authors: | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | Deposit date: | 2010-07-14 | Release date: | 2010-08-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.61 Å) | Cite: | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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3NY3
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![BU of 3ny3 by Molmil](/molmil-images/mine/3ny3) | Structure of the ubr-box of UBR2 in complex with N-degron | Descriptor: | E3 ubiquitin-protein ligase UBR2, N-degron, ZINC ION | Authors: | Matta-Camacho, E, Kozlov, G, Li, F, Gehring, K. | Deposit date: | 2010-07-14 | Release date: | 2010-08-11 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structural basis of substrate recognition and specificity in the N-end rule pathway. Nat.Struct.Mol.Biol., 17, 2010
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4N73
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![BU of 4n73 by Molmil](/molmil-images/mine/4n73) | |
3PT3
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![BU of 3pt3 by Molmil](/molmil-images/mine/3pt3) | Crystal structure of the C-terminal lobe of the human UBR5 HECT domain | Descriptor: | E3 ubiquitin-protein ligase UBR5 | Authors: | Matta-Camacho, E, Kozlov, G, Menade, M, Gehring, K. | Deposit date: | 2010-12-02 | Release date: | 2012-01-25 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.97 Å) | Cite: | Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase. Acta Crystallogr.,Sect.F, 68, 2012
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4M7B
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![BU of 4m7b by Molmil](/molmil-images/mine/4m7b) | Human tankyrase 2 - catalytic Parp domain in complex with an inhibitor UPF1854 | Descriptor: | 4-{2-[(6-methyl[1,2,4]triazolo[4,3-b]pyridazin-8-yl)amino]ethyl}phenol, SULFATE ION, Tankyrase-2, ... | Authors: | Karlberg, T, Camaioni, E, Schuler, H. | Deposit date: | 2013-08-12 | Release date: | 2014-03-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Design, Synthesis, Crystallographic Studies, and Preliminary Biological Appraisal of New Substituted Triazolo[4,3-b]pyridazin-8-amine Derivatives as Tankyrase Inhibitors. J.Med.Chem., 57, 2014
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1WVA
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![BU of 1wva by Molmil](/molmil-images/mine/1wva) | Crystal structure of human arginase I from twinned crystal | Descriptor: | Arginase 1, MANGANESE (II) ION, S-2-(BORONOETHYL)-L-CYSTEINE | Authors: | Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, P.C, Ochoa, A.C, Centeno, F, Christianson, D.W. | Deposit date: | 2004-12-14 | Release date: | 2005-09-06 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.94 Å) | Cite: | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response Proc.Natl.Acad.Sci.Usa, 102, 2005
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2AEB
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![BU of 2aeb by Molmil](/molmil-images/mine/2aeb) | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in immune response. | Descriptor: | 2(S)-AMINO-6-BORONOHEXANOIC ACID, Arginase 1, MANGANESE (II) ION | Authors: | Di Costanzo, L, Sabio, G, Mora, A, Rodriguez, P.C, Ochoa, A.C, Centeno, F, Christianson, D.W. | Deposit date: | 2005-07-21 | Release date: | 2005-09-06 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.29 Å) | Cite: | Crystal structure of human arginase I at 1.29 A resolution and exploration of inhibition in the immune response. Proc.Natl.Acad.Sci.Usa, 102, 2005
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3BCY
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![BU of 3bcy by Molmil](/molmil-images/mine/3bcy) | Crystal structure of YER067W | Descriptor: | Protein YER067W | Authors: | Kozlov, G, Gehring, K. | Deposit date: | 2007-11-13 | Release date: | 2008-11-18 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural and functional study of YER067W, a new protein involved in yeast metabolism control and drug resistance. Plos One, 5, 2010
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8CMX
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![BU of 8cmx by Molmil](/molmil-images/mine/8cmx) | |
5TDA
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![BU of 5tda by Molmil](/molmil-images/mine/5tda) | |
5UM3
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![BU of 5um3 by Molmil](/molmil-images/mine/5um3) | |
5TDB
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![BU of 5tdb by Molmil](/molmil-images/mine/5tdb) | Crystal structure of the human UBR-box domain from UBR2 in complex with asymmetrically double methylated arginine peptide | Descriptor: | 1,2-ETHANEDIOL, DA2-ILE-PHE-SER peptide, E3 ubiquitin-protein ligase UBR2, ... | Authors: | Munoz-Escobar, J, Kozlov, G, Gehring, K. | Deposit date: | 2016-09-19 | Release date: | 2017-03-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.101 Å) | Cite: | Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase. Structure, 25, 2017
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5TDD
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![BU of 5tdd by Molmil](/molmil-images/mine/5tdd) | Human UBR-box from UBR2 in complex with HIFS peptide | Descriptor: | 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase UBR2, HIS-ILE-PHE-SER peptide, ... | Authors: | Munoz-Escobar, J, Kozlov, G, Gehring, K. | Deposit date: | 2016-09-19 | Release date: | 2017-03-22 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase. Structure, 25, 2017
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3NTW
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![BU of 3ntw by Molmil](/molmil-images/mine/3ntw) | |
8AYF
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![BU of 8ayf by Molmil](/molmil-images/mine/8ayf) | Crystal structure of human Sphingosine-1-phosphate lyase 1 | Descriptor: | ACETATE ION, GLYCEROL, Sphingosine-1-phosphate lyase 1 | Authors: | Giardina, G, Catalano, F, Pampalone, G, Cellini, B. | Deposit date: | 2022-09-02 | Release date: | 2023-09-13 | Last modified: | 2024-01-03 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Dual species sphingosine-1-phosphate lyase inhibitors to combine antifungal and anti-inflammatory activities in cystic fibrosis: a feasibility study. Sci Rep, 13, 2023
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