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Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(1-ethyl-4-hydroxy-1H-1,2,3-triazol-5-yl)propanoic acid at 1.4 A resolution
Descriptor:	(2~{S})-2-azanyl-3-(3-ethyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, CITRIC ACID, ...
Authors:	Moellerud, S, Temperini, P, Kastrup, J.S.
Deposit date:	2018-12-07
Release date:	2019-04-17
Last modified:	2024-10-23
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62, 2019

Structure of GluA2 ligand-binding domain (S1S2J) in complex with the agonist (S)-2-Amino-3-(2-methyl-5-hydroxy-2H-1,2,3-triazol-4-yl)propanoic acid at 1.55 A resolution
Descriptor:	(2~{S})-2-azanyl-3-(2-methyl-5-oxidanyl-1,2,3-triazol-4-yl)propanoic acid, CHLORIDE ION, GLYCEROL, ...
Authors:	Moellerud, S, Temperini, P, Kastrup, J.S.
Deposit date:	2018-12-10
Release date:	2019-04-17
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.55 Å)
Cite:	Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands. J.Med.Chem., 62, 2019

Crystal structure of human Dihydroorotate Dehydrogenase in complex with the inhibitor 2-Hydroxy-N-(2-isopropyl-5-methyl-4-(pyridin-4-yloxy)phenyl)pyrazolo[1,5-a]pyridine-3-carboxamide
Descriptor:	ACETATE ION, Dihydroorotate dehydrogenase (quinone), mitochondrial, ...
Authors:	Alberti, M, Miggiano, R.
Deposit date:	2023-12-01
Release date:	2024-06-19
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	An alternative conformation of the N-terminal loop of human dihydroorotate dehydrogenase drives binding to a potent antiproliferative agent. Acta Crystallogr D Struct Biol, 80, 2024