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4EJ8
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BU of 4ej8 by Molmil
Apo HIV Protease (PR) dimer in closed form with fragment 1F1 in the outside/top of flap
Descriptor: 1,2-ETHANEDIOL, 1H-indole-6-carboxylic acid, DIMETHYL SULFOXIDE, ...
Authors:Tiefenbrunn, T, Stout, C.D.
Deposit date:2012-04-06
Release date:2013-05-01
Last modified:2024-02-28
Method:X-RAY DIFFRACTION (2.347 Å)
Cite:Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
Acs Chem.Biol., 8, 2013
4EJD
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BU of 4ejd by Molmil
HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1 in the outside/top of flap
Descriptor: 1H-indole-6-carboxylic acid, BETA-MERCAPTOETHANOL, GLYCEROL, ...
Authors:Tiefenbrunn, T, Stout, C.D.
Deposit date:2012-04-06
Release date:2013-05-01
Last modified:2014-02-19
Method:X-RAY DIFFRACTION (1.103 Å)
Cite:Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
Acs Chem.Biol., 8, 2013
4EJK
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BU of 4ejk by Molmil
HIV Protease (PR) dimer in closed form with pepstatin in active site and fragment 1F1-N in the outside/top of flap
Descriptor: INDOLYLPROPIONIC ACID, Protease, pepstatin
Authors:Tiefenbrunn, T, Stout, C.D.
Deposit date:2012-04-06
Release date:2013-05-01
Last modified:2018-03-07
Method:X-RAY DIFFRACTION (1.794 Å)
Cite:Small molecule regulation of protein conformation by binding in the Flap of HIV protease.
Acs Chem.Biol., 8, 2013
8D6E
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BU of 8d6e by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with RP-6306
Descriptor: (1P)-2-amino-1-(3-hydroxy-2,6-dimethylphenyl)-5,6-dimethyl-1H-pyrrolo[2,3-b]pyridine-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6D
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BU of 8d6d by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with compound 39
Descriptor: (1P)-2-amino-5-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6F
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BU of 8d6f by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with Eph receptor inhibitor / compound 41
Descriptor: (1M)-2-amino-1-(5-hydroxy-2-methylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, SULFATE ION
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
8D6C
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BU of 8d6c by Molmil
Crystal Structure of Human Myt1 Kinase domain Bounded with compound 28
Descriptor: (1P)-2-amino-6-bromo-1-(3-hydroxy-2,6-dimethylphenyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide, 1,2-ETHANEDIOL, GLYCEROL, ...
Authors:Pau, V.P.T, Mao, D.Y.L, Mader, P, Orlicky, S, Sicheri, F.
Deposit date:2022-06-06
Release date:2022-07-27
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306.
J.Med.Chem., 65, 2022
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