3G5V
 
 | | Antibodies Specifically Targeting a Locally Misfolded Region of Tumor Associated EGFR | | Descriptor: | 806 light chain, 808 heavy chain, ACETATE ION, ... | | Authors: | Garrett, T.P.J, Burgess, A.W, Huyton, T, Xu, Y. | | Deposit date: | 2009-02-05 | | Release date: | 2010-02-09 | | Last modified: | 2011-10-12 | | Method: | X-RAY DIFFRACTION (2.001 Å) | | Cite: | Antibodies specifically targeting a locally misfolded region of tumor associated EGFR
Proc.Natl.Acad.Sci.USA, 106, 2009
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6M6P
 | | Structure of Marine bacterial laminarinase mutant E135A in complex with 1,3-beta-cellotriosyl-glucose | | Descriptor: | CALCIUM ION, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-4)-beta-D-glucopyranose-(1-3)-alpha-D-glucopyranose, laminarinase | | Authors: | Yang, J, Xu, Y, Tanokura, M, Long, L, Miyakawa, T. | | Deposit date: | 2020-03-16 | | Release date: | 2020-09-23 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Molecular Basis for Substrate Recognition and Catalysis by a Marine Bacterial Laminarinase.
Appl.Environ.Microbiol., 86, 2020
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2XI4
 | | Torpedo californica Acetylcholinesterase in Complex with Aflatoxin B1 (Orthorhombic Space Group) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, AFLATOXIN B1, ... | | Authors: | Sanson, B, Colletier, J.P, Xu, Y, Lang, P.T, Jiang, H, Silman, I, Sussman, J.L, Weik, M. | | Deposit date: | 2010-06-28 | | Release date: | 2011-03-23 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Backdoor Opening Mechanism in Acetylcholinesterase Based on X-Ray Crystallography and Molecular Dynamics Simulations.
Protein Sci., 20, 2011
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4HSU
 | | Crystal structure of LSD2-NPAC with H3(1-26)in space group P21 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Histone H3, Lysine-specific histone demethylase 1B, ... | | Authors: | Chen, F, Dong, Z, Fang, J, Xu, Y. | | Deposit date: | 2012-10-30 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.988 Å) | | Cite: | Structural insight into substrate recognition by histone demethylase LSD2/KDM1b.
Cell Res., 23, 2013
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4IA0
 | | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | | Descriptor: | 5-bromo-2-{2-ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl}-6-octylpyrimidin-4(3H)-one, MAGNESIUM ION, ZINC ION, ... | | Authors: | Ren, J, Chen, T, Xu, Y. | | Deposit date: | 2012-12-05 | | Release date: | 2014-01-01 | | Method: | X-RAY DIFFRACTION (2.17 Å) | | Cite: | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
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4I9Z
 | | Crystal structure of the PDE5A1 catalytic domain in complex with novel inhibitors | | Descriptor: | 5-bromo-2-{5-[(4-methylpiperazin-1-yl)acetyl]-2-propoxyphenyl}-6-(propan-2-yl)pyrimidin-4(3H)-one, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | | Authors: | Ren, J, Chen, T, Xu, Y. | | Deposit date: | 2012-12-05 | | Release date: | 2014-01-01 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.08 Å) | | Cite: | Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5.
Bioorg.Med.Chem.Lett., 23, 2013
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4GU0
 | | Crystal structure of LSD2 with H3 | | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Histone H3.3, Lysine-specific histone demethylase 1B, ... | | Authors: | Chen, F, Yang, H, Dong, Z, Fang, J, Zhu, T, Gong, W, Xu, Y. | | Deposit date: | 2012-08-29 | | Release date: | 2013-02-13 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (3.103 Å) | | Cite: | Structural insight into substrate recognition by histone demethylase LSD2/KDM1b
Cell Res., 23, 2013
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2K3R
 | | Pfu Rpp21 structure and assignments | | Descriptor: | Ribonuclease P protein component 4, ZINC ION | | Authors: | Amero, C.D, Foster, M.P, Boomershine, W.P, Xu, Y. | | Deposit date: | 2008-05-15 | | Release date: | 2008-12-02 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Solution structure of Pyrococcus furiosus RPP21, a component of the archaeal RNase P holoenzyme, and interactions with its RPP29 protein partner.
Biochemistry, 47, 2008
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8JWZ
 | | Crystal structure of A2AR-T4L in complex with AB928 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | | Deposit date: | 2023-06-29 | | Release date: | 2023-08-16 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.37 Å) | | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors.
Sci China Life Sci, 67, 2024
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8JWY
 | | Crystal structure of A2AR-T4L in complex with 2-118 | | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[2-oxidanylidene-1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]pyridin-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, Adenosine receptor A2a,Endolysin, ... | | Authors: | Weng, Y, Chen, Y, Xu, Y, Song, G. | | Deposit date: | 2023-06-29 | | Release date: | 2023-08-16 | | Last modified: | 2024-05-15 | | Method: | X-RAY DIFFRACTION (2.33 Å) | | Cite: | Structural insight into the dual-antagonistic mechanism of AB928 on adenosine A 2 receptors.
Sci China Life Sci, 67, 2024
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2K1E
 | | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA | | Descriptor: | water soluble analogue of potassium channel, KcsA | | Authors: | Ma, D, Xu, Y, Tillman, T, Tang, P, Meirovitch, E, Eckenhoff, R, Carnini, A. | | Deposit date: | 2008-02-29 | | Release date: | 2008-11-11 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2JST
 | | Four-Alpha-Helix Bundle with Designed Anesthetic Binding Pockets II: Halothane Effects on Structure and Dynamics | | Descriptor: | 2-BROMO-2-CHLORO-1,1,1-TRIFLUOROETHANE, Four-Alpha-Helix Bundle | | Authors: | Cui, T, Bondarenko, V, Ma, D, Canlas, C, Brandon, N.R, Johansson, J.S, Tang, P, Xu, Y. | | Deposit date: | 2007-07-12 | | Release date: | 2008-05-27 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Four-alpha-helix bundle with designed anesthetic binding pockets. Part II: halothane effects on structure and dynamics
Biophys.J., 94, 2008
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2K58
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2GBL
 | | Crystal Structure of Full Length Circadian Clock Protein KaiC with Phosphorylation Sites | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase kaiC, MAGNESIUM ION | | Authors: | Pattanayek, R, Williams, D.R, Pattanayek, S, Xu, Y, Mori, T, Johnson, C.H, Stewart, P.L, Egli, M. | | Deposit date: | 2006-03-10 | | Release date: | 2007-01-23 | | Last modified: | 2021-07-28 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Analysis of KaiA-KaiC protein interactions in the cyano-bacterial circadian clock using hybrid structural methods.
Embo J., 25, 2006
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2K59
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2KB1
 | | NMR studies of a channel protein without membrane: structure and dynamics of water-solubilized KcsA | | Descriptor: | WSK3 | | Authors: | Ma, D, Xu, Y, Tillman, T, Tang, P, Meirovitch, E, Eckenhoff, R, Carnini, A. | | Deposit date: | 2008-11-19 | | Release date: | 2008-12-09 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | NMR studies of a channel protein without membranes: structure and dynamics of water-solubilized KcsA
Proc.Natl.Acad.Sci.USA, 105, 2008
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2KZ1
 | | Inter-molecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric back-protonation and 2D NOESY | | Descriptor: | Interferon alpha-2, Soluble IFN alpha/beta receptor | | Authors: | Nudelman, I, Akabayov, S.R, Schnur, E, Biron, Z, Levy, R, Xu, Y, Yang, D, Anglister, J. | | Deposit date: | 2010-06-10 | | Release date: | 2010-06-23 | | Last modified: | 2021-08-18 | | Method: | SOLUTION NMR | | Cite: | Intermolecular interactions in a 44 kDa interferon-receptor complex detected by asymmetric reverse-protonation and two-dimensional NOESY
Biochemistry, 49, 2010
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2KSR
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6D1S
 | | Crystal structure of an apo chimeric human alpha1GABAA receptor | | Descriptor: | chimeric alpha1GABAA receptor | | Authors: | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | | Deposit date: | 2018-04-12 | | Release date: | 2018-08-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
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6CDU
 | | Crystal structure of a chimeric human alpha1GABAA receptor in complex with alphaxalone | | Descriptor: | (3a,5a)-3-Hydroxypregnane-11,20-dione, chimeric alpha1GABAA receptor | | Authors: | Chen, Q, Arjunan, P, Cohen, A.E, Xu, Y, Tang, P. | | Deposit date: | 2018-02-09 | | Release date: | 2018-08-22 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.45 Å) | | Cite: | Structural basis of neurosteroid anesthetic action on GABAAreceptors.
Nat Commun, 9, 2018
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6K9L
 | | 4.27 Angstrom resolution cryo-EM structure of human dimeric ATM kinase | | Descriptor: | Serine-protein kinase ATM | | Authors: | Xiao, J, Liu, M, Qi, Y, Chaban, Y, Gao, C, Tian, Y, Yu, Z, Li, J, Zhang, P, Xu, Y. | | Deposit date: | 2019-06-16 | | Release date: | 2019-12-25 | | Last modified: | 2024-03-27 | | Method: | ELECTRON MICROSCOPY (4.27 Å) | | Cite: | Structural insights into the activation of ATM kinase.
Cell Res., 29, 2019
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8IKU
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8J0I
 | | Aldo-keto reductase KmAKR | | Descriptor: | NADPH-dependent alpha-keto amide reductase, SODIUM ION | | Authors: | Xu, S.Y, Zhou, L, Xu, Y, Wang, Y.J, Zheng, Y.G. | | Deposit date: | 2023-04-11 | | Release date: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (1.91 Å) | | Cite: | Aldo-keto reductase KmAKR from Kluyveromyces marxianus
To Be Published
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1RRK
 | | Crystal Structure Analysis of the Bb segment of Factor B | | Descriptor: | COBALT (II) ION, Complement factor B, IODIDE ION, ... | | Authors: | Ponnuraj, K, Xu, Y, Macon, K, Moore, D, Volanakis, J.E, Narayana, S.V. | | Deposit date: | 2003-12-08 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell, 14, 2004
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1RS0
 | | Crystal Structure Analysis of the Bb segment of Factor B complexed with Di-isopropyl-phosphate (DIP) | | Descriptor: | Complement factor B, DIISOPROPYL PHOSPHONATE, IODIDE ION, ... | | Authors: | Ponnuraj, K, Xu, Y, Macon, K, Moore, D, Volanakis, J.E, Narayana, S.V. | | Deposit date: | 2003-12-09 | | Release date: | 2004-12-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structural analysis of engineered Bb fragment of complement factor B: insights into the activation mechanism of the alternative pathway C3-convertase.
Mol.Cell, 14, 2004
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