7SU1
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![BU of 7su1 by Molmil](/molmil-images/mine/7su1) | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.106 in complex with CTLA-4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cytotoxic T-lymphocyte protein 4, Fab heavy chain, ... | Authors: | Lee, P.S, Chau, B, Strop, P. | Deposit date: | 2021-11-15 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.53 Å) | Cite: | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
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7SU0
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![BU of 7su0 by Molmil](/molmil-images/mine/7su0) | Crystal structure of an acidic pH-selective Ipilimumab variant Ipi.105 in complex with CTLA-4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CITRATE ANION, Cytotoxic T-lymphocyte protein 4, ... | Authors: | Lee, P.S, Chau, B, Strop, P. | Deposit date: | 2021-11-15 | Release date: | 2022-03-02 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.41 Å) | Cite: | Improved therapeutic index of an acidic pH-selective antibody. Mabs, 14, 2022
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7KHD
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![BU of 7khd by Molmil](/molmil-images/mine/7khd) | Human GITR-GITRL complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, Tumor necrosis factor receptor superfamily member 18 | Authors: | Wang, F, Chau, B, West, S.M, Strop, P. | Deposit date: | 2020-10-21 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.956102 Å) | Cite: | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
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7KHX
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![BU of 7khx by Molmil](/molmil-images/mine/7khx) | Mouse GITR-GITRL complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Tumor necrosis factor ligand superfamily member 18, ... | Authors: | Wang, F, Chau, B, West, S.M, Strop, P. | Deposit date: | 2020-10-22 | Release date: | 2021-03-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.20569849 Å) | Cite: | Structures of mouse and human GITR-GITRL complexes reveal unique TNF superfamily interactions. Nat Commun, 12, 2021
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4AIF
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![BU of 4aif by Molmil](/molmil-images/mine/4aif) | AIP TPR domain in complex with human Hsp90 peptide | Descriptor: | AH RECEPTOR-INTERACTING PROTEIN, HEAT SHOCK PROTEIN HSP 90-ALPHA, SULFATE ION | Authors: | Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C. | Deposit date: | 2012-02-09 | Release date: | 2013-01-23 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.006 Å) | Cite: | Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition. Plos One, 7, 2012
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4APO
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![BU of 4apo by Molmil](/molmil-images/mine/4apo) | AIP TPR domain in complex with human Tomm20 peptide | Descriptor: | AH RECEPTOR-INTERACTING PROTEIN, DODECAETHYLENE GLYCOL, MITOCHONDRIAL IMPORT RECEPTOR SUBUNIT TOM20 HOMOLOG, ... | Authors: | Morgan, R.M.L, Roe, S.M, Pearl, L.H, Prodromou, C. | Deposit date: | 2012-04-04 | Release date: | 2013-01-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.895 Å) | Cite: | Structure of the Tpr Domain of Aip: Lack of Client Protein Interaction with the C-Terminal Alpha-7 Helix of the Tpr Domain of Aip is Sufficient for Pituitary Adenoma Predisposition. Plos One, 7, 2012
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4G10
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![BU of 4g10 by Molmil](/molmil-images/mine/4g10) | LigG from Sphingobium sp. SYK-6 is related to the glutathione transferase omega class | Descriptor: | ACETATE ION, GLUTATHIONE, Glutathione S-transferase homolog, ... | Authors: | Meux, E, Prosper, P, Masai, E, Mulliert Carlin, G, Dumarcay, S, Morel, M, Didierjean, C, Gelhaye, E, Favier, F. | Deposit date: | 2012-07-10 | Release date: | 2012-10-03 | Last modified: | 2017-11-15 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Sphingobium sp. SYK-6 LigG involved in lignin degradation is structurally and biochemically related to the glutathione transferase omega class. Febs Lett., 586, 2012
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6WCZ
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![BU of 6wcz by Molmil](/molmil-images/mine/6wcz) | CryoEM structure of full-length ZIKV NS5-hSTAT2 complex | Descriptor: | Non-structural protein 5, Signal transducer and activator of transcription 2, ZINC ION | Authors: | Boxiao, W, Stephanie, T, Kang, Z, Maria, T.S, Jian, F, Jiuwei, L, Linfeng, G, Wendan, R, Yanxiang, C, Ethan, C.V, HeaJin, H, Matthew, J.E, Sean, E.O, Adolfo, G.S, Hong, Z, Rong, H, Jikui, S. | Deposit date: | 2020-03-31 | Release date: | 2020-07-08 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for STAT2 suppression by flavivirus NS5. Nat.Struct.Mol.Biol., 27, 2020
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1H85
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![BU of 1h85 by Molmil](/molmil-images/mine/1h85) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH VAL 136 REPLACED BY LEU (V136L) | Descriptor: | FERREDOXIN--NADP REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Hermoso, J.A, Mayoral, T, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 2001-01-24 | Release date: | 2001-11-28 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Role of a Cluster of Hydrophobic Residues Near the Fad Cofactor in Anabaena Pcc 7119 Ferredoxin-Nadp+ Reductase for Optimal Complex Formation and Electron Transfer to Ferredoxin J.Biol.Chem., 276, 2001
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1H42
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![BU of 1h42 by Molmil](/molmil-images/mine/1h42) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH THR 155 REPLACED BY GLY, ALA 160 REPLACED BY THR AND LEU 263 REPLACED BY PRO (T155G-A160T-L263P) | Descriptor: | FERREDOXIN--NADP+ REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Hermoso, J.A, Mayoral, T, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 2002-09-26 | Release date: | 2003-09-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Involvement of the Pyrophosphate and the 2'-Phosphate Binding Regions of Ferredoxin-Nadp+ Reductase in Coenzyme Specificity J.Biol.Chem., 278, 2003
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4L1Z
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4L1Y
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![BU of 4l1y by Molmil](/molmil-images/mine/4l1y) | |
4L20
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![BU of 4l20 by Molmil](/molmil-images/mine/4l20) | |
4L21
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4OOF
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![BU of 4oof by Molmil](/molmil-images/mine/4oof) | M. tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase W203F mutant bound to fosmidomycin and NADPH | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... | Authors: | Allen, C.L, Kholodar, S.A, Murkin, A.S, Gulick, A.M. | Deposit date: | 2014-01-31 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin. Biochemistry, 53, 2014
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4OOE
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![BU of 4ooe by Molmil](/molmil-images/mine/4ooe) | M. tuberculosis 1-deoxy-d-xylulose-5-phosphate reductoisomerase W203Y mutant bound to fosmidomycin and NADPH | Descriptor: | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, 3-[FORMYL(HYDROXY)AMINO]PROPYLPHOSPHONIC ACID, MANGANESE (II) ION, ... | Authors: | Allen, C.L, Kholodar, S.A, Murkin, A.S, Gulick, A.M. | Deposit date: | 2014-01-31 | Release date: | 2014-06-18 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.826 Å) | Cite: | Alteration of the Flexible Loop in 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase Boosts Enthalpy-Driven Inhibition by Fosmidomycin. Biochemistry, 53, 2014
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1J7A
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![BU of 1j7a by Molmil](/molmil-images/mine/1j7a) | STRUCTURE OF THE ANABAENA FERREDOXIN D68K MUTANT | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN I | Authors: | Hurley, J.K, Weber-Main, A.M, Stankovich, M.T, Benning, M.M, Thoden, J.B, VanHooke, J.L, Holden, H.M, Chae, Y.K, Xia, B, Cheng, H, Markley, J.L, Martinez-Julvez, M, Gomez-Moreno, C, Schmeits, J.L, Tollen, G. | Deposit date: | 2001-05-16 | Release date: | 2001-05-23 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry, 36, 1997
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3EFY
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1OGJ
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![BU of 1ogj by Molmil](/molmil-images/mine/1ogj) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH LEU 263 REPLACED BY PRO (L263P) | Descriptor: | FERREDOXIN--NADP+ REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Hermoso, J.A, Mayoral, T, Martinez Julvez, M, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 2003-05-06 | Release date: | 2003-09-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Involvement of the Pyrophosphate and the 2'-Phosphate Binding Regions of Ferredoxin-Nadp+ Reductase in Coenzyme Specificity J.Biol.Chem., 278, 2003
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1OGI
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![BU of 1ogi by Molmil](/molmil-images/mine/1ogi) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH THR 155 REPLACED BY GLY AND ALA 160 REPLACED BY THR (T155G-A160T) | Descriptor: | FERREDOXIN--NADP+ REDUCTASE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION | Authors: | Hermoso, J.A, Mayoral, T, Julvez, M.M, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 2003-05-06 | Release date: | 2003-09-25 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Involvement of the Pyrophosphate and the 2'-Phosphate Binding Regions of Ferredoxin-Nadp+ Reductase in Coenzyme Specificity. J.Biol.Chem., 278, 2003
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3GQM
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1QOA
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![BU of 1qoa by Molmil](/molmil-images/mine/1qoa) | FERREDOXIN MUTATION C49S | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN | Authors: | Holden, H.M, Benning, M.M. | Deposit date: | 1997-08-14 | Release date: | 1998-01-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Iron-sulfur cluster cysteine-to-serine mutants of Anabaena -2Fe-2S- ferredoxin exhibit unexpected redox properties and are competent in electron transfer to ferredoxin:NADP+ reductase. Biochemistry, 36, 1997
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1QGZ
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![BU of 1qgz by Molmil](/molmil-images/mine/1qgz) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH LEU 78 REPLACED BY ASP (L78D) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, PROTEIN (FERREDOXIN:NADP+ REDUCTASE), SULFATE ION | Authors: | Hermoso, J.A, Mayoral, T, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | Deposit date: | 1999-05-10 | Release date: | 2002-02-27 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Role of a cluster of hydrophobic residues near the FAD cofactor in Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal complex formation and electron transfer to ferredoxin. J.Biol.Chem., 276, 2001
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3GQJ
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1QOB
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![BU of 1qob by Molmil](/molmil-images/mine/1qob) | FERREDOXIN MUTATION D62K | Descriptor: | FE2/S2 (INORGANIC) CLUSTER, FERREDOXIN, SULFATE ION | Authors: | Holden, H.M, Benning, M.M. | Deposit date: | 1997-08-14 | Release date: | 1998-01-14 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure-function relationships in Anabaena ferredoxin: correlations between X-ray crystal structures, reduction potentials, and rate constants of electron transfer to ferredoxin:NADP+ reductase for site-specific ferredoxin mutants. Biochemistry, 36, 1997
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