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7NDB
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BU of 7ndb by Molmil
EM structure of SARS-CoV-2 Spike glycoprotein in complex with COVOX-253H165L Fab
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Duyvesteyn, H.M.E, Zhao, Y, Ren, J, Stuart, D.
Deposit date:2021-01-30
Release date:2021-03-03
Last modified:2021-04-28
Method:ELECTRON MICROSCOPY (4.6 Å)
Cite:The antigenic anatomy of SARS-CoV-2 receptor binding domain.
Cell, 184, 2021
6CT2
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BU of 6ct2 by Molmil
MYST histone acetyltransferase KAT6A/B in complex with WM-1119
Descriptor: 3-fluoro-N'-[(2-fluorophenyl)sulfonyl]-5-(pyridin-2-yl)benzohydrazide, Histone acetyltransferase KAT8, MAGNESIUM ION, ...
Authors:Ren, B, Peat, T.S.
Deposit date:2018-03-22
Release date:2018-08-01
Last modified:2018-08-22
Method:X-RAY DIFFRACTION (2.128 Å)
Cite:Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature, 560, 2018
7M4T
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BU of 7m4t by Molmil
Menin bound to M-1121
Descriptor: Menin, methyl {(1S,2R)-2-[(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-{1-[(3-methoxy-1-{4-[(1S,4S)-5-propanoyl-2,5-diazabicyclo[2.2.1]heptane-2-sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}ethyl]cyclopentyl}carbamate, praseodymium triacetate
Authors:Stuckey, J.
Deposit date:2021-03-22
Release date:2021-08-11
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Discovery of M-1121 as an Orally Active Covalent Inhibitor of Menin-MLL Interaction Capable of Achieving Complete and Long-Lasting Tumor Regression.
J.Med.Chem., 64, 2021
6ITJ
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BU of 6itj by Molmil
Crystal structure of FGFR1 kinase domain in complex with compound 3
Descriptor: 4-azanyl-3-(3,5-dimethyl-1-benzofuran-2-yl)-2-phenyl-6~{H}-pyrazolo[3,4-d]pyridazin-7-one, Fibroblast growth factor receptor 1
Authors:Xu, Y, Liu, Q.
Deposit date:2018-11-23
Release date:2019-10-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.994 Å)
Cite:Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
6IUP
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BU of 6iup by Molmil
Crystal structure of FGFR4 kinase domain in complex with compound 5
Descriptor: DIMETHYL SULFOXIDE, Fibroblast growth factor receptor 4, N-{4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}prop-2-enamide
Authors:Xu, Y, Liu, Q.
Deposit date:2018-11-29
Release date:2019-11-06
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
8IF6
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BU of 8if6 by Molmil
Conformational Dynamics of the D53-D3-D14 Complex in Strigolactone Signaling
Descriptor: F-box/LRR-repeat MAX2 homolog, SKP1-like protein 20, Strigolactone esterase D14
Authors:Liu, S.M, Wang, J.
Deposit date:2023-02-17
Release date:2023-07-12
Last modified:2023-09-27
Method:ELECTRON MICROSCOPY (7.09 Å)
Cite:Conformational Dynamics of the D53-D3-D14 Complex in Strigolactone Signaling.
Plant Cell.Physiol., 64, 2023
5HU9
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BU of 5hu9 by Molmil
Crystal structure of ABL1 in complex with CHMFL-074
Descriptor: 1,2-ETHANEDIOL, 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[1-(pyridin-3-ylcarbonyl)piperidin-4-yl]oxy}phenyl)-3-(trifluoromethyl)benzamide, CHLORIDE ION, ...
Authors:Kong, L.L, Yun, C.H.
Deposit date:2016-01-27
Release date:2016-07-13
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.529 Å)
Cite:Discovery and characterization of a novel potent type II native and mutant BCR-ABL inhibitor (CHMFL-074) for Chronic Myeloid Leukemia (CML)
Oncotarget, 7, 2016
3W95
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BU of 3w95 by Molmil
Crystal structure of 2A proteinase (C110A) from enterovirus 71
Descriptor: Genome polyprotein, ZINC ION
Authors:Mu, Z, Gao, X, Cui, S.
Deposit date:2013-03-27
Release date:2013-09-04
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal Structure of 2A Proteinase from Hand, Foot and Mouth Disease Virus
J.Mol.Biol., 425, 2013
7KQB
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BU of 7kqb by Molmil
SARS-CoV-2 spike glycoprotein:Fab 5A6 complex I
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 5A6 heavy chain, Fab 5A6 light chain, ...
Authors:Asarnow, D, Charles, C, Cheng, Y.
Deposit date:2020-11-14
Release date:2021-05-26
Last modified:2021-06-23
Method:ELECTRON MICROSCOPY (2.42 Å)
Cite:Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Cell, 184, 2021
7KQE
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BU of 7kqe by Molmil
SARS-CoV-2 spike glycoprotein:Fab 3D11 complex
Descriptor: Fab 3D11 heavy chain, Fab 3D11 light chain, Spike glycoprotein
Authors:Asarnow, D, Charles, C, Cheng, Y.
Deposit date:2020-11-15
Release date:2021-05-26
Last modified:2021-06-23
Method:ELECTRON MICROSCOPY (2.88 Å)
Cite:Structural insight into SARS-CoV-2 neutralizing antibodies and modulation of syncytia.
Cell, 184, 2021
6BA2
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BU of 6ba2 by Molmil
Crystal structure of MYST acetyltransferase domain in complex with inhibitor
Descriptor: 4-fluoro-5-methyl-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide, CHLORIDE ION, GLYCEROL, ...
Authors:Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W.
Deposit date:2017-10-11
Release date:2018-08-01
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.85003817 Å)
Cite:Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature, 560, 2018
6IUO
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BU of 6iuo by Molmil
Crystal structure of FGFR4 kinase domain in complex with a covalent inhibitor
Descriptor: Fibroblast growth factor receptor 4, N-({4-[4-amino-3-(3,5-dimethyl-1-benzofuran-2-yl)-7-oxo-6,7-dihydro-2H-pyrazolo[3,4-d]pyridazin-2-yl]phenyl}methyl)prop-2-enamide
Authors:Xu, Y, Liu, Q.
Deposit date:2018-11-29
Release date:2019-10-23
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Discovery and Development of a Series of Pyrazolo[3,4-d]pyridazinone Compounds as the Novel Covalent Fibroblast Growth Factor Receptor Inhibitors by the Rational Drug Design.
J.Med.Chem., 62, 2019
6BA4
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BU of 6ba4 by Molmil
Crystal structure of MYST acetyltransferase domain in complex with Acetyl-CoA cofactor
Descriptor: ACETYL COENZYME *A, Histone acetyltransferase KAT8, S-{(3S,5R,9R)-1-[(2R,3R,4R,5R)-5-(6-amino-9H-purin-9-yl)-3-hydroxy-4-(phosphonooxy)tetrahydrofuran-2-yl]-3,5,9-trihydroxy-8,8-dimethyl-3,5-dioxido-10,14-dioxo-2,4,6-trioxa-11,15-diaza-3lambda~5~,5lambda~5~-diphosphaheptadecan-17-yl} ethanethioate, ...
Authors:Hermans, S.J, Chung, M.C, Peat, T.S, Baell, J.B, Thomas, T, Parker, M.W.
Deposit date:2017-10-12
Release date:2018-08-01
Last modified:2020-01-08
Method:X-RAY DIFFRACTION (1.949 Å)
Cite:Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth.
Nature, 560, 2018
5J87
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BU of 5j87 by Molmil
Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a Highly Selective Irreversible BTK Kinase Inhibitor
Descriptor: N-[3-(5-{[3-(acryloylamino)-4-(morpholine-4-carbonyl)phenyl]amino}-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl]-4-tert-butylbenzamide, Tyrosine-protein kinase BTK
Authors:Yun, C.H, Zhang, S.
Deposit date:2016-04-07
Release date:2017-04-19
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.59 Å)
Cite:Discovery of N-(3-(5-((3-acrylamido-4-(morpholine-4-carbonyl)phenyl)amino)-1-methyl-6-oxo-1,6-dihydropyridin-3-yl)-2-methylphenyl)-4-(tert-butyl)benzamide (CHMFL-BTK-01) as a highly selective irreversible Bruton's tyrosine kinase (BTK) inhibitor.
Eur J Med Chem, 131, 2017
7NXA
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BU of 7nxa by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 B.1.351 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-222 Fab heavy chain, COVOX-222 Fab light chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NXB
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BU of 7nxb by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, COVOX-222 Fab heavy chain, COVOX-222 Fab light chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.67 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NX6
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BU of 7nx6 by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-222 Fab Heavy chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NXC
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BU of 7nxc by Molmil
Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with ACE2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Processed angiotensin-converting enzyme 2, Spike protein S1
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (3.14 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NX7
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BU of 7nx7 by Molmil
Crystal structure of the K417N mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRIC ACID, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NX9
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BU of 7nx9 by Molmil
Crystal structure of the N501Y mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, COVOX-222 Fab heavy chain, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7NX8
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BU of 7nx8 by Molmil
Crystal structure of the K417T mutant receptor binding domain of SARS-CoV-2 Spike glycoprotein in complex with COVOX-222 and EY6A Fabs
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, CITRIC ACID, ...
Authors:Zhou, D, Ren, J, Stuart, D.
Deposit date:2021-03-17
Release date:2021-04-07
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Antibody evasion by the P.1 strain of SARS-CoV-2.
Cell, 184, 2021
7BP4
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BU of 7bp4 by Molmil
Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)
Descriptor: ASP-ASP-ASP-ASP-TYR, GLYCEROL, Histone H2A.6, ...
Authors:Luo, Q, Baihui, W.
Deposit date:2020-03-21
Release date:2020-11-11
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B.
Proc.Natl.Acad.Sci.USA, 117, 2020
7BP6
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BU of 7bp6 by Molmil
Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)
Descriptor: Histone H2A.6, Histone H2B.1, NRP1-CTAD
Authors:Luo, Q, Baihui, W.
Deposit date:2020-03-21
Release date:2020-11-11
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B.
Proc.Natl.Acad.Sci.USA, 117, 2020
7BP2
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BU of 7bp2 by Molmil
Structural mechanism directing nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)
Descriptor: GLYCEROL, Histone H2A.6, Histone H2B.1, ...
Authors:Luo, Q, Baihui, W.
Deposit date:2020-03-21
Release date:2020-11-11
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B.
Proc.Natl.Acad.Sci.USA, 117, 2020
7BP5
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BU of 7bp5 by Molmil
Structural insights into nucleosome reorganization by NAP1-RELATED PROTEIN 1 (NRP1)
Descriptor: ASN-ASP-PRO-ASP-TYR, GLYCEROL, Histone H2A.6, ...
Authors:Luo, Q, Baihui, W.
Deposit date:2020-03-21
Release date:2020-11-11
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:NAP1-Related Protein 1 (NRP1) has multiple interaction modes for chaperoning histones H2A-H2B.
Proc.Natl.Acad.Sci.USA, 117, 2020

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