7NXB

Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs

Summary for 7NXB

• Entry DOI: 10.2210/pdb7nxb/pdb
• Related: 7BXC 7NX6 7NX7 7NX8 7NX9 7NXA
• Descriptor: EY6A Fab heavy chain, EY6A Fab light chain, Spike protein S1, ... (10 entities in total)
• Functional Keywords: sars-cov-2 b.1.1.7 variant, b.1.351 variant, p.1 variant, antibody, receptor-binding-domain, spike, neutralisation, viral protein/immune system, viral protein, immune system, viral protein-immune system complex
• Biological source: Homo sapiens; More
• Total number of polymer chains: 5
• Total formula weight: 119575.58

Authors

Zhou, D.,Ren, J.,Stuart, D. (deposition date: 2021-03-17, release date: 2021-04-07, Last modification date: 2024-01-31)

• Primary citation: Dejnirattisai, W.,Zhou, D.,Supasa, P.,Liu, C.,Mentzer, A.J.,Ginn, H.M.,Zhao, Y.,Duyvesteyn, H.M.E.,Tuekprakhon, A.,Nutalai, R.,Wang, B.,Lopez-Camacho, C.,Slon-Campos, J.,Walter, T.S.,Skelly, D.,Costa Clemens, S.A.,Naveca, F.G.,Nascimento, V.,Nascimento, F.,Fernandes da Costa, C.,Resende, P.C.,Pauvolid-Correa, A.,Siqueira, M.M.,Dold, C.,Levin, R.,Dong, T.,Pollard, A.J.,Knight, J.C.,Crook, D.,Lambe, T.,Clutterbuck, E.,Bibi, S.,Flaxman, A.,Bittaye, M.,Belij-Rammerstorfer, S.,Gilbert, S.C.,Carroll, M.W.,Klenerman, P.,Barnes, E.,Dunachie, S.J.,Paterson, N.G.,Williams, M.A.,Hall, D.R.,Hulswit, R.J.G.,Bowden, T.A.,Fry, E.E.,Mongkolsapaya, J.,Ren, J.,Stuart, D.I.,Screaton, G.R.; Antibody evasion by the P.1 strain of SARS-CoV-2.; Cell, 184:2939-, 2021; PubMed: 33852911; DOI: 10.1016/j.cell.2021.03.055

Experimental method

X-RAY DIFFRACTION (2.67 Å)