7NXB

Crystal structure of the receptor binding domain of SARS-CoV-2 P.1 variant Spike glycoprotein in complex with COVOX-222 and EY6A Fabs

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (H)	EY6A Fab heavy chain	polymer	226	24346.3	1		Homo sapiens
2	B (L)	EY6A Fab light chain	polymer	215	23315.9	1		Homo sapiens
3	C (E)	Spike protein S1	polymer	205	23172.0	1	UniProt (P0DTC2) Pfam (PF09408)	Severe acute respiratory syndrome coronavirus 2 (2019-nCoV SARS-CoV-2)
4	D (A)	COVOX-222 Fab heavy chain	polymer	224	23461.2	1		Homo sapiens
5	E (B)	COVOX-222 Fab light chain	polymer	214	23327.9	1		Homo sapiens
6	F, I, J, K, L... (H, E, A, B)	SULFATE ION	non-polymer		96.1	15	Chemie (SO4)
7	G, N (E, A)	GLYCEROL	non-polymer		92.1	2	Chemie (GOL)
8	H (E)	2-acetamido-2-deoxy-beta-D-glucopyranose	non-polymer		221.2	1	Chemie (NAG)
9	M (A)	DI(HYDROXYETHYL)ETHER	non-polymer		106.1	1	Chemie (PEG)
10	AA, BA, Y, Z (A, B, L, E)	water	water		18.0	78	Chemie (HOH)

Sequence modifications

E: 333 - 528 (UniProt: P0DTC2)

PDB	External Database	Details
Glu 324	-	expression tag
Thr 325	-	expression tag
Gly 326	-	expression tag
His 327	-	expression tag
His 328	-	expression tag
His 329	-	expression tag
His 330	-	expression tag
His 331	-	expression tag
His 332	-	expression tag
Thr 417	Lys 417	variant
Lys 484	Glu 484	variant
Tyr 501	Asn 501	variant
Lys 527	Pro 527	variant

Contents of the asymmetric unit

Polymers	Number of chains	5
	Total formula weight	117623.1
Non-Polymers*	Number of molecules	19
	Total formula weight	1952.5
All*	Total formula weight	119575.6

*Water molecules are not included.