4TV8
Tubulin-Maytansine complex
Summary for 4TV8
Entry DOI | 10.2210/pdb4tv8/pdb |
Related | 4TV9 |
Descriptor | Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3beta,4beta,5beta,10beta,11E,13E)-maytansine, ... (13 entities in total) |
Functional Keywords | cell cycle, cytoskeleton, tubulin fold, microtubule |
Biological source | Rattus norvegicus (Norway Rat) More |
Cellular location | Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043 |
Total number of polymer chains | 6 |
Total formula weight | 265398.44 |
Authors | Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2014-06-26, release date: 2014-08-27, Last modification date: 2023-12-20) |
Primary citation | Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111:13817-13821, 2014 Cited by PubMed: 25114240DOI: 10.1073/pnas.1408124111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.103 Å) |
Structure validation
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