4TV8

Tubulin-Maytansine complex

Summary for 4TV8

Entry DOI	10.2210/pdb4tv8/pdb
Related	4TV9
Descriptor	Tubulin alpha-1B chain, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, (3beta,4beta,5beta,10beta,11E,13E)-maytansine, ... (13 entities in total)
Functional Keywords	cell cycle, cytoskeleton, tubulin fold, microtubule
Biological source	Rattus norvegicus (Norway Rat) More
Cellular location	Cytoplasm, cytoskeleton: P81947 Cytoplasm, cytoskeleton (By similarity): Q6B856 Golgi apparatus: P63043
Total number of polymer chains	6
Total formula weight	265398.44
Authors	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. (deposition date: 2014-06-26, release date: 2014-08-27, Last modification date: 2023-12-20)
Primary citation	Prota, A.E.,Bargsten, K.,Diaz, J.F.,Marsh, M.,Cuevas, C.,Liniger, M.,Neuhaus, C.,Andreu, J.M.,Altmann, K.H.,Steinmetz, M.O. A new tubulin-binding site and pharmacophore for microtubule-destabilizing anticancer drugs. Proc.Natl.Acad.Sci.USA, 111:13817-13821, 2014 Cited by PubMed: 25114240 DOI: 10.1073/pnas.1408124111 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.103 Å)

Structure validation