4TV8
Tubulin-Maytansine complex
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, C | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain, tubulin alpha chain |
2 | B, D | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) In PDB | Bos taurus (cattle) | Tubulin beta chain |
3 | E | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) In PDB | Rattus norvegicus (Norway Rat) | Stathmin-like protein B3,RB3 |
4 | F | Tubulin-Tyrosine Ligase | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) In PDB | Gallus gallus (Chicken) | |
5 | A, C | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) | |||
6 | A, B, C, D | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) | |||
7 | A, B, C | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) | |||
8 | A, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
9 | B, D | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) | |||
10 | B | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
11 | D | (3beta,4beta,5beta,10beta,11E,13E)-maytansine | non-polymer | 692.2 | 1 | Chemie (3GT) | |||
12 | F | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) | |||
13 | water | water | 18.0 | 671 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
PDB | External Database | Details |
---|---|---|
Met 3 | - | expression tag |
Ala 4 | - | expression tag |
PDB | External Database | Details |
---|---|---|
His 379 | - | expression tag |
His 380 | - | expression tag |
His 381 | - | expression tag |
His 382 | - | expression tag |
His 383 | - | expression tag |
His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 261631.3 | |
Non-Polymers* | Number of molecules | 17 |
Total formula weight | 3767.1 | |
All* | Total formula weight | 265398.4 |