4TV8
Tubulin-Maytansine complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Tubulin alpha-1B chain | polymer | 451 | 50204.4 | 2 | UniProt (P81947) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | Alpha-tubulin ubiquitous,Tubulin K-alpha-1,Tubulin alpha-ubiquitous chain, tubulin alpha chain |
| 2 | B, D (B, D) | Tubulin beta-2B chain | polymer | 445 | 49999.9 | 2 | UniProt (Q6B856) Pfam (PF00091) Pfam (PF03953) | Bos taurus (cattle) | Tubulin beta chain |
| 3 | E (E) | Stathmin-4 | polymer | 143 | 16844.2 | 1 | UniProt (P63043) Pfam (PF00836) | Rattus norvegicus (Norway Rat) | Stathmin-like protein B3,RB3 |
| 4 | F (F) | Tubulin-Tyrosine Ligase | polymer | 384 | 44378.5 | 1 | UniProt (E1BQ43) | Gallus gallus (Chicken) | |
| 5 | G, P (A, C) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 2 | Chemie (GTP) PubChem (177679032) PubChem (135400627) PubChem (135487750) PubChem (136088935) PubChem (136803486) PubChem (135398633) PubChem (135544356) PubChem (135547949) PubChem (135600366) PubChem (135749822) PubChem (136005188) PubChem (136073923) PubChem (136240914) PubChem (136664747) PubChem (136772743) PubChem (136772744) PubChem (136803487) PubChem (137286749) PubChem (164715984) PubChem (171699466) | |||
| 6 | H, L, Q, V (A, B, C, D) | MAGNESIUM ION | non-polymer | 24.3 | 4 | Chemie (MG) PubChem (888) | |||
| 7 | I, M, N, S (A, B, C) | CALCIUM ION | non-polymer | 40.1 | 4 | Chemie (CA) PubChem (271) | |||
| 8 | J, R (A, C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) PubChem (753) | |||
| 9 | K, T (B, D) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 2 | Chemie (GDP) PubChem (136073927) PubChem (135398619) PubChem (135402030) PubChem (135431654) PubChem (135566337) PubChem (135760556) PubChem (136026707) PubChem (136053418) PubChem (136663964) PubChem (136664748) PubChem (136759848) PubChem (136759849) PubChem (136759850) PubChem (136836636) PubChem (136847074) PubChem (172898537) | |||
| 10 | O (B) | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) PubChem (4478249) | |||
| 11 | U (D) | (3beta,4beta,5beta,10beta,11E,13E)-maytansine | non-polymer | 692.2 | 1 | Chemie (3GT) PubChem (17999949) PubChem (17999960) PubChem (21014206) PubChem (21158526) PubChem (23305922) PubChem (23307879) PubChem (177502164) PubChem (23376917) PubChem (54604312) PubChem (44413553) PubChem (3000319) PubChem (73948235) PubChem (547450) PubChem (89256750) PubChem (90244687) PubChem (90250727) PubChem (91154516) PubChem (94435758) PubChem (99654455) PubChem (101529024) PubChem (5906862) PubChem (6713048) PubChem (123671613) PubChem (123720997) PubChem (53298358) PubChem (9961630) PubChem (137495257) PubChem (15560161) PubChem (57504783) PubChem (57517213) PubChem (162943646) PubChem (166642248) PubChem (166910383) PubChem (170930070) PubChem (59422092) PubChem (71308235) PubChem (73940256) PubChem (73952298) PubChem (88533897) PubChem (89045299) PubChem (90254106) PubChem (91410140) PubChem (94435759) PubChem (94435760) PubChem (117946707) PubChem (5281828) PubChem (5319318) PubChem (5365290) PubChem (6477151) PubChem (126576555) PubChem (131852887) PubChem (15560162) PubChem (16058067) PubChem (16058095) PubChem (138720388) PubChem (154612101) PubChem (156328070) PubChem (162943647) PubChem (162943648) PubChem (162943649) PubChem (162943650) PubChem (167022546) PubChem (169544602) PubChem (172885021) | |||
| 12 | W (F) | PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER | non-polymer | 505.2 | 1 | Chemie (ACP) PubChem (91532) PubChem (46936826) PubChem (91885473) PubChem (157749842) PubChem (4799) PubChem (134943439) PubChem (157749839) | |||
| 13 | AA, BA, CA, X, Y... (D, E, F, A, B...) | water | water | 18.0 | 671 | Chemie (HOH) |
Sequence modifications
E: 5 - 145 (UniProt: P63043)
F: 1 - 378 (UniProt: E1BQ43)
| PDB | External Database | Details |
|---|---|---|
| Met 3 | - | expression tag |
| Ala 4 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| His 379 | - | expression tag |
| His 380 | - | expression tag |
| His 381 | - | expression tag |
| His 382 | - | expression tag |
| His 383 | - | expression tag |
| His 384 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 261631.3 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 3767.1 | |
| All* | Total formula weight | 265398.4 |
