4Q21
MOLECULAR SWITCH FOR SIGNAL TRANSDUCTION: STRUCTURAL DIFFERENCES BETWEEN ACTIVE AND INACTIVE FORMS OF PROTOONCOGENIC RAS PROTEINS
Summary for 4Q21
Entry DOI | 10.2210/pdb4q21/pdb |
Descriptor | C-H-RAS P21 PROTEIN CATALYTIC DOMAIN, MAGNESIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... (4 entities in total) |
Functional Keywords | oncogene protein |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane. Isoform 2: Nucleus: P01112 |
Total number of polymer chains | 1 |
Total formula weight | 21791.65 |
Authors | Kim, S.-H. (deposition date: 1991-09-25, release date: 1992-07-15, Last modification date: 2024-02-28) |
Primary citation | Milburn, M.V.,Tong, L.,deVos, A.M.,Brunger, A.,Yamaizumi, Z.,Nishimura, S.,Kim, S.H. Molecular switch for signal transduction: structural differences between active and inactive forms of protooncogenic ras proteins. Science, 247:939-945, 1990 Cited by PubMed: 2406906PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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