4N14

Crystal structure of Cdc20 and apcin complex

Summary for 4N14

Entry DOI	10.2210/pdb4n14/pdb
Related	4GGA 4GGC 4GGD
Descriptor	Cell division cycle protein 20 homolog, 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl [(1R)-2,2,2-trichloro-1-(pyrimidin-2-ylamino)ethyl]carbamate (3 entities in total)
Functional Keywords	cell cycle, mitosis, securin, ubiquitination, wd40, cell cycle-cell cycle inhibitor complex, cell cycle/cell cycle inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : Q12834
Total number of polymer chains	1
Total formula weight	34876.21
Authors	Luo, X.,Tian, W.,Yu, H. (deposition date: 2013-10-03, release date: 2014-08-20, Last modification date: 2024-02-28)
Primary citation	Sackton, K.L.,Dimova, N.,Zeng, X.,Tian, W.,Zhang, M.,Sackton, T.B.,Meaders, J.,Pfaff, K.L.,Sigoillot, F.,Yu, H.,Luo, X.,King, R.W. Synergistic blockade of mitotic exit by two chemical inhibitors of the APC/C. Nature, 514:646-649, 2014 Cited by PubMed: 25156254 DOI: 10.1038/nature13660 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation