4J7U
Crystal structure of human sepiapterin reductase in complex with sulfathiazole
Summary for 4J7U
| Entry DOI | 10.2210/pdb4j7u/pdb |
| Related | 4HWK 4J7X |
| Descriptor | Sepiapterin reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, ... (7 entities in total) |
| Functional Keywords | reductase, oxidoreductase-antibiotic complex, oxidoreductase/antibiotic |
| Biological source | Homo sapiens (human) |
| Cellular location | Cytoplasm: P35270 |
| Total number of polymer chains | 4 |
| Total formula weight | 130340.05 |
| Authors | Groenlund Pedersen, M.,Pojer, F.,Johnsson, K. (deposition date: 2013-02-14, release date: 2013-06-05, Last modification date: 2023-09-20) |
| Primary citation | Haruki, H.,Pedersen, M.G.,Gorska, K.I.,Pojer, F.,Johnsson, K. Tetrahydrobiopterin biosynthesis as an off-target of sulfa drugs. Science, 340:987-991, 2013 Cited by PubMed: 23704574DOI: 10.1126/science.1232972 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.44 Å) |
Structure validation
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