4J7U
Crystal structure of human sepiapterin reductase in complex with sulfathiazole
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D | Sepiapterin reductase | polymer | 288 | 31290.0 | 4 | UniProt (P35270) Pfam (PF00106) In PDB | Homo sapiens (human) | SPR |
2 | A, B, C, D | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
3 | A, B, C, D | 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide | non-polymer | 255.3 | 4 | Chemie (YTZ) | |||
4 | A, B, C, D | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
5 | A, B, C | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) | |||
6 | B, C | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
7 | water | water | 18.0 | 149 | Chemie (HOH) |
Sequence modifications
A, B, C, D: -2 - 258 (UniProt: P35270)
PDB | External Database | Details |
---|---|---|
Met -29 | - | expression tag |
Ser -28 | - | expression tag |
Tyr -27 | - | expression tag |
Tyr -26 | - | expression tag |
His -25 | - | expression tag |
His -24 | - | expression tag |
His -23 | - | expression tag |
His -22 | - | expression tag |
His -21 | - | expression tag |
His -20 | - | expression tag |
Leu -19 | - | expression tag |
Glu -18 | - | expression tag |
Ser -17 | - | expression tag |
Thr -16 | - | expression tag |
Ser -15 | - | expression tag |
Leu -14 | - | expression tag |
Tyr -13 | - | expression tag |
Lys -12 | - | expression tag |
Lys -11 | - | expression tag |
Ala -10 | - | expression tag |
Gly -9 | - | expression tag |
Leu -8 | - | expression tag |
Glu -7 | - | expression tag |
Gly -6 | - | expression tag |
Val -5 | - | expression tag |
Arg -4 | - | expression tag |
Thr -3 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 4 |
Total formula weight | 125160.1 | |
Non-Polymers* | Number of molecules | 20 |
Total formula weight | 5179.9 | |
All* | Total formula weight | 130340.0 |