4FGU

Crystal structure of prolegumain

Summary for 4FGU

Entry DOI	10.2210/pdb4fgu/pdb
Related	4aw9 4awa 4awb
Descriptor	Legumain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
Functional Keywords	cysteine protease, aep, asparaginyl endopeptidase, substrate specificity, mhcii, antigen processing, proenzyme, cancer, lysosomal, hydrolase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	99702.16
Authors	Dall, E.,Brandstetter, H. (deposition date: 2012-06-05, release date: 2013-07-03, Last modification date: 2020-07-29)
Primary citation	Dall, E.,Brandstetter, H. Mechanistic and structural studies on legumain explain its zymogenicity, distinct activation pathways, and regulation. Proc.Natl.Acad.Sci.USA, 110:10940-10945, 2013 Cited by PubMed: 23776206 DOI: 10.1073/pnas.1300686110 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.9 Å)

Structure validation