4EJH
Human Cytochrome P450 2A13 in complex with 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK)
Summary for 4EJH
| Entry DOI | 10.2210/pdb4ejh/pdb |
| Related | 2P85 3T3S 4EJG 4EJI 4EJJ |
| Descriptor | Cytochrome P450 2A13, PROTOPORPHYRIN IX CONTAINING FE, 4-[methyl(nitroso)amino]-1-(pyridin-3-yl)butan-1-one, ... (5 entities in total) |
| Functional Keywords | cyp2a13, cytochrome p450 2a13, p450 2a13, heme protein, monooxygenase, drug metabolism, xenobiotic metabolism, endoplasmic reticulum, membrane, oxidoreductase |
| Biological source | Homo sapiens (human) |
| Cellular location | Endoplasmic reticulum membrane; Peripheral membrane protein: Q16696 |
| Total number of polymer chains | 8 |
| Total formula weight | 444797.52 |
| Authors | DeVore, N.M.,Scott, E.E. (deposition date: 2012-04-06, release date: 2012-06-06, Last modification date: 2023-09-13) |
| Primary citation | DeVore, N.M.,Scott, E.E. Nicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone binding and access channel in human cytochrome P450 2A6 and 2A13 enzymes. J.Biol.Chem., 287:26576-26585, 2012 Cited by PubMed: 22700965DOI: 10.1074/jbc.M112.372813 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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