3NKX

Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome

Summary for 3NKX

Entry DOI	10.2210/pdb3nkx/pdb
Related	2o02 2o98 3e6y 3lw1 3m50 3m51
Descriptor	14-3-3 protein zeta/delta, Peptide of RAF proto-oncogene serine/threonine-protein kinase, PROPANOIC ACID, ... (4 entities in total)
Functional Keywords	protein binding, signaling protein
Biological source	Homo sapiens (human) More
Cellular location	Cytoplasm : P63104 P04049
Total number of polymer chains	4
Total formula weight	58044.61
Authors	Schumacher, B.,Weyand, M.,Ottmann, C. (deposition date: 2010-06-21, release date: 2010-09-15, Last modification date: 2023-11-01)
Primary citation	Molzan, M.,Schumacher, B.,Ottmann, C.,Baljuls, A.,Polzien, L.,Weyand, M.,Thiel, P.,Rose, R.,Rose, M.,Kuhenne, P.,Kaiser, M.,Rapp, U.R.,Kuhlmann, J.,Ottmann, C. Impaired binding of 14-3-3 to C-RAF in Noonan syndrome suggests new approaches in diseases with increased Ras signaling Mol.Cell.Biol., 30:4698-4711, 2010 Cited by PubMed: 20679480 DOI: 10.1128/MCB.01636-09 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation