3HNG
Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide
Summary for 3HNG
| Entry DOI | 10.2210/pdb3hng/pdb |
| Descriptor | Vascular endothelial growth factor receptor 1, N-(4-chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide, CHLORIDE ION, ... (4 entities in total) |
| Functional Keywords | receptor tyrosine kinase, vegfr1, flt1, kinase domain, inhibitor, activation loop, vascular endothelial growth factor receptor, structural genomics, structural genomics consortium, sgc, sgc stockholm, angiogenesis, atp-binding, cell membrane, developmental protein, differentiation, disulfide bond, glycoprotein, immunoglobulin domain, kinase, membrane, nucleotide-binding, phosphoprotein, receptor, secreted, transferase, transmembrane, tyrosine-protein kinase |
| Biological source | Homo sapiens (human) |
| Cellular location | Isoform Flt1: Cell membrane; Single-pass type I membrane protein. Isoform sFlt1: Secreted: P17948 |
| Total number of polymer chains | 1 |
| Total formula weight | 41454.38 |
| Authors | Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (deposition date: 2009-05-31, release date: 2009-06-30, Last modification date: 2023-11-01) |
| Primary citation | Tresaugues, L.,Roos, A.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, A.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Moche, M.,Nyman, T.,Persson, C.,Kragh-Nielsen, T.,Kotzch, A.,Sagemark, J.,Schueler, H.,Schutz, P.,Siponen, M.I.,Svensson, L.,Thorsell, A.G.,Van der Berg, S.,Weigelt, J.,Welin, M.,Wisniewska, M.,Nordlund, P. Crystal structure of VEGFR1 in complex with N-(4-Chlorophenyl)-2-((pyridin-4-ylmethyl)amino)benzamide To be Published, |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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