1VOL
TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX
Summary for 1VOL
| Entry DOI | 10.2210/pdb1vol/pdb |
| Descriptor | DNA (5'-D(*GP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*CP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*C)-3'), PROTEIN (TRANSCRIPTION FACTOR IIB (TFIIB)), ... (4 entities in total) |
| Functional Keywords | transcription initiation, molecular recognition, complex, transcription factor, transcription regulation, dna, transcription-dna complex, transcription/dna |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 4 |
| Total formula weight | 54964.28 |
| Authors | Nikolov, D.B.,Chen, H.,Halay, E.D.,Usheva, A.U.,Hisatake, K.,Lee, D.K.,Roeder, R.G.,Burley, S.K. (deposition date: 1996-04-29, release date: 1996-11-08, Last modification date: 2024-02-14) |
| Primary citation | Nikolov, D.B.,Chen, H.,Halay, E.D.,Usheva, A.A.,Hisatake, K.,Lee, D.K.,Roeder, R.G.,Burley, S.K. Crystal structure of a TFIIB-TBP-TATA-element ternary complex. Nature, 377:119-128, 1995 Cited by PubMed Abstract: The crystal structure of the transcription factor IIB (TFIIB)/TATA box-binding protein (TBP)/TATA-element ternary complex is described at 2.7 A resolution. Core TFIIB resembles cyclin A, and recognizes the preformed TBP-DNA complex through protein-protein and protein-DNA interactions. The amino-terminal domain of core TFIIB forms the downstream surface of the ternary complex, where it could fix the transcription start site. The remaining surfaces of TBP and the TFIIB can interact with TBP-associated factors, other class II initiation factors, and transcriptional activators and coactivators. PubMed: 7675079DOI: 10.1038/377119a0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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