1VOL
TFIIB (HUMAN CORE DOMAIN)/TBP (A.THALIANA)/TATA ELEMENT TERNARY COMPLEX
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006352 | biological_process | DNA-templated transcription initiation |
| A | 0017025 | molecular_function | TBP-class protein binding |
| A | 0070897 | biological_process | transcription preinitiation complex assembly |
| B | 0003677 | molecular_function | DNA binding |
| B | 0005515 | molecular_function | protein binding |
| B | 0005634 | cellular_component | nucleus |
| B | 0006351 | biological_process | DNA-templated transcription |
| B | 0006352 | biological_process | DNA-templated transcription initiation |
| B | 0006366 | biological_process | transcription by RNA polymerase II |
| B | 0016251 | molecular_function | RNA polymerase II general transcription initiation factor activity |
Functional Information from PROSITE/UniProt
| site_id | PS00351 |
| Number of Residues | 50 |
| Details | TFIID Transcription factor TFIID repeat signature. YnPkrFaaVImRirePKttaLIFaSGKMvctGAKsedfskmAarkyariV |
| Chain | Residue | Details |
| B | TYR52-VAL101 | |
| B | TYR143-LEU192 |
| site_id | PS00782 |
| Number of Residues | 16 |
| Details | TFIIB Transcription factor TFIIB repeat signature. GRandAIASACLYIAC |
| Chain | Residue | Details |
| A | GLY153-CYS168 | |
| A | GLY247-SER262 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"1"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"2"} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 4 |
| Details | Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 72 |
| Details | Region: {"description":"Necessary for TATA box-bound TBP complex formation","evidences":[{"source":"PubMed","id":"8515820","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"8516311","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Region: {"description":"Core promoter DNA-binding","evidences":[{"source":"PubMed","id":"10619841","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7675079","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 10 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"27193682","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5IYD","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine; by autocatalysis","evidences":[{"source":"PubMed","id":"12931194","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI9 |
| Number of Residues | 76 |
| Details | Repeat: {"description":"1","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI10 |
| Number of Residues | 77 |
| Details | Repeat: {"description":"2","evidences":[{"evidenceCode":"ECO:0000255"}]} |
| Chain | Residue | Details |
