1EA1
Cytochrome P450 14 alpha-sterol demethylase (CYP51) from Mycobacterium tuberculosis in complex with fluconazole
Summary for 1EA1
Entry DOI | 10.2210/pdb1ea1/pdb |
Related | 1E9X |
Descriptor | CYTOCHROME P450 51-LIKE RV0764C, PROTOPORPHYRIN IX CONTAINING FE, 2-(2,4-DIFLUOROPHENYL)-1,3-DI(1H-1,2,4-TRIAZOL-1-YL)PROPAN-2-OL, ... (4 entities in total) |
Functional Keywords | oxidoreductase, cytochrome p450, 14 alpha-sterol demethylase, azole inhibitors |
Biological source | MYCOBACTERIUM TUBERCULOSIS |
Total number of polymer chains | 1 |
Total formula weight | 52422.09 |
Authors | Podust, L.M.,Poulos, T.L.,Waterman, M.R. (deposition date: 2000-11-02, release date: 2000-11-06, Last modification date: 2023-12-13) |
Primary citation | Podust, L.M.,Poulos, T.L.,Waterman, M.R. Crystal Structure of Cytochrome P450 14Alpha -Sterol Demethylase (Cyp51) from Mycobacterium Tuberculosis in Complex with Azole Inhibitors Proc.Natl.Acad.Sci.USA, 98:3068-, 2001 Cited by PubMed: 11248033DOI: 10.1073/PNAS.061562898 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
Download full validation report