9ZVR

Crystal structure of HTLV-1 protease bound to darunavir at 2.1 angstroms with truncated flaps

Summary for 9ZVR

• Entry DOI: 10.2210/pdb9zvr/pdb
• Descriptor: HTLV-1 Protease, TETRAETHYLENE GLYCOL, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ... (6 entities in total)
• Functional Keywords: htlv-1, protease, drug resistance, protease inhibitor, complex, hydrolase inhibitor complex, hydrolase, hydrolase-hydrolase inhibitor complex, viral protein, viral protein-inhibitor complex, viral protein/inhibitor
• Biological source: Human T-cell leukemia virus type I
• Total number of polymer chains: 2
• Total formula weight: 26238.09

Authors

Shaqra, A.M.,Lockbaum, G.J.,Intravaia, L.E.,Schiffer, C.A. (deposition date: 2025-12-30, release date: 2026-01-21)

• Primary citation: Shaqra, A.M.,Lockbaum, G.J.,Intravaia, L.E.,Schiffer, C.A.; Crystal structure of HTLV-1 protease bound to darunavir at 2.1 angstroms with truncated flaps; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.1 Å)