9ZO8

Structure of RyR1 in presence of rosuvastatin (including auxiliary transmembrane helices TMx1 and TMx2; Ca2+/CFF/ATP dataset; closed pore)

This is a non-PDB format compatible entry.

Summary for 9ZO8

• Entry DOI: 10.2210/pdb9zo8/pdb
• EMDB information: 74471
• Descriptor: Peptidyl-prolyl cis-trans isomerase FKBP1A, Ryanodine receptor 1, ADENOSINE-5'-TRIPHOSPHATE, ... (7 entities in total)
• Functional Keywords: calcium, ion channel, membrane protein, transport protein
• Biological source: Oryctolagus cuniculus (rabbit); More
• Total number of polymer chains: 8
• Total formula weight: 2318956.72

Authors

Weninger, G.,Marks, A.R. (deposition date: 2025-12-15, release date: 2026-09-30)

• Primary citation: Weninger, G.,Reiken, S.,Yuan, Q.,Miotto, M.C.,Chang, A.,Liu, Y.,Wronska, A.,Dridi, H.,Marks, A.R.; Structural basis for rosuvastatin-induced activation of skeletal muscle ryanodine receptor 1; Nat Commun, 2026; DOI: 10.1038/s41467-026-77372-9

Experimental method

ELECTRON MICROSCOPY (2.7 Å)