9Z4H

Cryo-EM structure of human Wntless in complex with Wnt5a at 1:1 stoichiometry

Summary for 9Z4H

• Entry DOI: 10.2210/pdb9z4h/pdb
• EMDB information: 73803
• Descriptor: Protein Wnt-5a, Protein wntless homolog, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (8 entities in total)
• Functional Keywords: wnt transporter, wnt5a, wnt signaling, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 111955.54

Authors

Ge, Y.,de Almeida Magalhaes, T.,Wu, H.,Wang, Z.,Salic, A.,Jiang, J.,Huang, P. (deposition date: 2025-11-10, release date: 2026-06-10)

• Primary citation: Ge, Y.,de Almeida Magalhaes, T.,Wu, H.,van den Boomen, D.J.H.,Nguyen, T.U.,Dou, T.,Yadav, G.P.,Lee, S.,Wang, Z.,Lemoff, A.,Luo, X.,Jin, Z.,Jiang, J.,Salic, A.,Huang, P.; Conformational cycling of the Wntless transporter drives trafficking and secretion of Wnt morphogens; To Be Published,

Experimental method

ELECTRON MICROSCOPY (2.64 Å)