9Z4H
Cryo-EM structure of human Wntless in complex with Wnt5a at 1:1 stoichiometry
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Protein Wnt-5a | polymer | 355 | 39913.2 | 1 | UniProt (P41221) | Homo sapiens (human) | |
| 2 | B (B) | Protein wntless homolog | polymer | 575 | 66088.1 | 1 | UniProt (Q5T9L3) | Homo sapiens (human) | Integral membrane protein GPR177,Protein evenness interrupted homolog,EVI,Putative NF-kappa-B-activating protein 373 |
| 3 | C (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 1 | In PDB GlyTouCan (G42666HT) | |||
| 4 | D (A) | PALMITOLEIC ACID | non-polymer | 254.4 | 1 | Chemie (PAM) PubChem (445638) | |||
| 5 | E, F (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) PubChem (24139) | |||
| 6 | G, J, K, L, M (A, B) | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 787.1 | 5 | Chemie (PCW) | |||
| 7 | H (B) | CHOLESTEROL | non-polymer | 386.7 | 1 | Chemie (CLR) PubChem (5997) | |||
| 8 | I (B) | 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 510.7 | 1 | Chemie (LPE) |
Sequence modifications
A: 36 - 380 (UniProt: P41221)
B: 1 - 541 (UniProt: Q5T9L3)
| PDB | External Database | Details |
|---|---|---|
| Ala 381 | - | expression tag |
| Ala 382 | - | expression tag |
| Asp 383 | - | expression tag |
| Tyr 384 | - | expression tag |
| Lys 385 | - | expression tag |
| Asp 386 | - | expression tag |
| Asp 387 | - | expression tag |
| Asp 388 | - | expression tag |
| Asp 389 | - | expression tag |
| Ala 390 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 542 | - | expression tag |
| Ala 543 | - | expression tag |
| Ala 544 | - | expression tag |
| Leu 545 | - | expression tag |
| Glu 546 | - | expression tag |
| Val 547 | - | expression tag |
| Leu 548 | - | expression tag |
| Phe 549 | - | expression tag |
| Gln 550 | - | expression tag |
| Gly 551 | - | expression tag |
| Pro 552 | - | expression tag |
| Gly 553 | - | expression tag |
| Ala 554 | - | expression tag |
| Ala 555 | - | expression tag |
| Glu 556 | - | expression tag |
| Asp 557 | - | expression tag |
| Gln 558 | - | expression tag |
| Val 559 | - | expression tag |
| Asp 560 | - | expression tag |
| Pro 561 | - | expression tag |
| Arg 562 | - | expression tag |
| Leu 563 | - | expression tag |
| Ile 564 | - | expression tag |
| Asp 565 | - | expression tag |
| Gly 566 | - | expression tag |
| Lys 567 | - | expression tag |
| His 568 | - | expression tag |
| His 569 | - | expression tag |
| His 570 | - | expression tag |
| His 571 | - | expression tag |
| His 572 | - | expression tag |
| His 573 | - | expression tag |
| His 574 | - | expression tag |
| His 575 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 106001.3 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 424.4 | |
| Non-Polymers* | Number of molecules | 10 |
| Total formula weight | 5529.8 | |
| All* | Total formula weight | 111955.5 |
